Vitamin D Status of Mice Deficient in Scavenger Receptor Class B Type 1, Cluster Determinant 36 and ATP-Binding Cassette Proteins G5/G8

Kiourtzidis, Mikis; Kühn, Julia; Brandsch, Corinna; Stangl, Gabriele I.

doi:10.3390/nu12082169

Cited by 13 publications

(6 citation statements)

References 48 publications

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“…In the upper small intestine, dietary vitamin D is absorbed together with other dietary lipids as a result of passive diffusion [22][23][24]. Recently, it has been demonstrated that cholesterol transporters, including cluster of differentiation 36 (CD36), scavenger receptor class B type I (SR-BI), and Niemann-Pick C1-Like 1 (NPC1-L1), are also engaged in vitamin D transport across the enterocyte [25][26][27]. In enterocytes, vitamin D is loaded into chylomicrons and then released into the lymph nodes [28,29].…”

Section: Methodology and Literature Searchmentioning

confidence: 99%

The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?

Szymczak-Pajor

Miazek²,

Selmi³

et al. 2022

IJMS

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Adipose tissue plays an important role in systemic metabolism via the secretion of adipocytokines and storing and releasing energy. In obesity, adipose tissue becomes dysfunctional and characterized by hypertrophied adipocytes, increased inflammation, hypoxia, and decreased angiogenesis. Although adipose tissue is one of the major stores of vitamin D, its deficiency is detective in obese subjects. In the presented review, we show how vitamin D regulates numerous processes in adipose tissue and how their dysregulation leads to metabolic disorders. The molecular response to vitamin D in adipose tissue affects not only energy metabolism and adipokine and anti-inflammatory cytokine production via the regulation of gene expression but also genes participating in antioxidant defense, adipocytes differentiation, and apoptosis. Thus, its deficiency disturbs adipocytokines secretion, metabolism, lipid storage, adipogenesis, thermogenesis, the regulation of inflammation, and oxidative stress balance. Restoring the proper functionality of adipose tissue in overweight or obese subjects is of particular importance in order to reduce the risk of developing obesity-related complications, such as cardiovascular diseases and diabetes. Taking into account the results of experimental studies, it seemed that vitamin D may be a remedy for adipose tissue dysfunction, but the results of the clinical trials are not consistent, as some of them show improvement and others no effect of this vitamin on metabolic and insulin resistance parameters. Therefore, further studies are required to evaluate the beneficial effects of vitamin D, especially in overweight and obese subjects, due to the presence of a volumetric dilution of this vitamin among them.

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Section: Methodology and Literature Searchmentioning

confidence: 99%

The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?

Szymczak-Pajor

Miazek²,

Selmi³

et al. 2022

IJMS

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show abstract

“…However, these results are consistent with previous data obtained in Abcg5/g8 −/− mice. [21] In this last study, Abcg5/g8 −/− mice tended to have higher levels of vitamin D 3 in the serum and liver, together with notably higher levels of 25(OH)D 3 in the serum and kidney, which suggested that ABCG5/G8 could be involved in vitamin D reverse transport. The accumulation of vitamin D in female plasmas and in male livers suggests delayed clearance in the former and hepatic retention in the latter.…”

Section: Discussionmentioning

confidence: 73%

The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine

Antoine

May

Margier

et al. 2021

Molecular Nutrition Food Res

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Scope: Most people are vitamin D insufficient around the world. Vitamin D intestinal absorption should thus be optimized. The role of the ATP-binging cassette G5/G8 (ABCG5/G8) heterodimer in vitamin D intestinal efflux is investigated. Methods and Results: Both cholecalciferol and 25-hydroxycholecalciferol apical effluxes are increased by ABCG5/G8 overexpression in human Griptite cells. Mice deficient in ABCG5/G8 at the intestinal level (I-Abcg5/g8 −/− mice) display an accumulation of cholecalciferol in plasma in females and in liver in males compared to control animals. I-Abcg5/g8 −/− mice display a delay in cholecalciferol postprandial response after gavage compared with controls. 25-Hydroxycholecalciferol transfer from plasma to lumen is observed in vivo in intestine-perfused mice, and the lack of intestinal ABCG5/G8 complex induces a decrease in this efflux, while vitamin D bile excretion remains unchanged. Conclusion: Overall, it is showed for the first time that the ABCG5/G8 heterodimer regulates the kinetics of absorption of dietary vitamin D by contributing to its efflux back to the lumen, and that it also participates in vitamin D transintestinal efflux.

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“…This finding is consistent with the following experimental results. Rainer Hubmann et al's study revealed that NOTCH3 and CD36 influence the uptake, tissue distribution, and activation of vitamin D (Kiourtzidis et al 2020); inhibition of CD36 partially reversed the migration promotion effect of CAFs on CRC cells. By reducing CD36 level in vivo, the migration ability of CRC cells is significantly repressed (Fedirko et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Identification of Vitamin D-related gene signature to predict colorectal cancer prognosis (v0.1)"

Rathod¹

2021

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Colorectal cancer (CRC) is one of the most common malignant carcinomas worldwide with poor prognosis, imposing an increasingly heavy burden on patients. Previous experiments and epidemiological studies have shown that vitamin D and vitamin D-related genes play a vital role in CRC. Therefore, we aimed to construct a vitamin D-related gene signature to predict prognosis in CRC. The CRC data from The Cancer Genome Atlas (TCGA) was performed as the training set. A total of 173 vitamin D-related genes in the TCGA CRC dataset were screened, and 17 genes associated with CRC prognosis were identified from them. Then, a vitamin D-related gene signature consisting of those 17 genes was established by univariate and multivariate Cox analyses. Moreover, four external datasets (GSE17536, GSE103479, GSE39582, and GSE17537) were used as testing set to validate the stability of this signature. The high-risk group presented a significantly poorer overall survival than low-risk group in both of training set and testing sets. Besides, the areas under the curve (AUCs) for signature on OS in training set at 1, 3, and 5 years were 0.710, 0.708, 0.710 respectively. The AUCs of the ROC curve in GSE17536 for 1, 3, and 5 years were 0.649, 0.654, and 0.694. These results indicated the vitamin D-related gene signature model could effectively predict the survival status of CRC patients. This vitamin D-related gene signature was also correlated with TNM stage in CRC clinical parameters, and the higher risk score from this model was companied with higher clinical stage. Furthermore, the high accuracy of this prognostic signature was validated and confirmed by nomogram model. In conclusion, we have proposed a novel vitamin D-related gene model to predict the prognosis of CRC, which will help provide new therapeutic targets and act as potential prognostic biomarkers for CRC.

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Vitamin D Status of Mice Deficient in Scavenger Receptor Class B Type 1, Cluster Determinant 36 and ATP-Binding Cassette Proteins G5/G8

Cited by 13 publications

References 48 publications

The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?

The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?

The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine

Peer Review #1 of "Identification of Vitamin D-related gene signature to predict colorectal cancer prognosis (v0.1)"

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