Vitamin D status of middle-aged women at 65–71°N in relation to dietary intake and exposure to ultraviolet radiation

Brustad, Magritt; Alsaker, Elin; Engelsen, Ola; Aksnes, Lage; Lund, Eiliv

doi:10.1079/phn2003536

Cited by 164 publications

(168 citation statements)

References 30 publications

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“…In a northern area of Norway (69°N), high intake of cod liver oil substantially reduced the expected seasonality of serum 25(OH)D in the population [17]. Despite consumption of foods containing substantial amounts of vitamin D, serum 25(OH)D levels generally are lower in residents of northern areas of Norway [18] and Finland [19]. Consistent with this finding, one more recent study in Sweden reported that incidence rates of type 1 diabetes increased with increasing latitude [20], suggesting that the apparent reversal in incidence rates compared with expectation may be disappearing with time there.…”

Section: Discussionmentioning

confidence: 99%

The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide

et al. 2008

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Aims/hypothesis This study is an analysis of the relationship between ultraviolet B (UVB) irradiance, the primary source of circulating vitamin D in humans, and age-standardised incidence rates of type 1 diabetes mellitus in children, according to region of the world. Methods The association of UVB irradiance adjusted for cloud cover to incidence rates of type 1 diabetes in children aged <14 years during 1990-1994 in 51 regions worldwide was assessed using multiple regression. Incidence data were obtained from the Diabetes Mondial Project Group. Results Incidence rates were generally higher at higher latitudes (R 2 = 0.25, p <0.001). According to multiple regression, UVB irradiance adjusted for cloud cover was inversely associated with incidence rates (p<0.05), while per capita health expenditure (p<0.004) was positively associated (overall R 2 =0.42, p<0.0001). Conclusions/interpretation An association was found between low UVB irradiance and high incidence rates of type 1 childhood diabetes after controlling for per capita health expenditure. Incidence rates of type 1 diabetes approached zero in regions worldwide with high UVB irradiance, adding new support to the concept of a role of vitamin D in reducing the risk of the disease.

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Section: Discussionmentioning

confidence: 99%

The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide

et al. 2008

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“…prevalence of vitamin D deficiency is high in the winter and spring months. Thus, although intake alone at current levels may not yield very high levels of vitamin D in circulation, it is an important factor in preventing vitamin D deficiency in winter months, as shown in other studies (16)(17)(18)42). Finally, because we do not have detailed information about sun exposure for participants in either cohort, we used state of residence divided by geographic latitude as a limited proxy for potential solar UVB exposure.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Intake and the Risk for Pancreatic Cancer in Two Cohort Studies

Skinner

Michaud²,

Giovannucci

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

151

105

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Vitamin D and its analogues exhibit potent antitumor effects in many tissues, including the pancreas. Normal and malignant pancreatic tissues were recently shown to express high levels of vitamin D 1-A-hydroxylase, which converts circulating 25-hydroxyvitamin D to active 1,25-dihydroxyvitamin D. We examined associations between dietary intake of vitamin D, calcium, and retinol and subsequent risk for pancreatic cancer. We conducted prospective studies in

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“…Additional sources are natural dietary content, vitamin food fortification and supplements. The latitude of geographical location is of importance for obtaining sufficient sunlight for the synthesis of active vitamin D. Seasonal variation in vitamin D levels have been illustrated in the Nordic countries [14,15] and in the United Kingdom where high prevalence of deficient vitamin D levels have been found during winter and spring [16]. In the Nordic countries, exposure to the sun is below critical level for half of the year.…”

Section: Introduction and Objectivesmentioning

confidence: 99%

High levels of vitamin D associated with less ischemic heart disease – a nested case-control study among rural men in Sweden

Holmberg

Rignell-Hydbom

Lindh

et al. 2017

Ann Agric Environ Med.

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Holmberg S, Rignell-Hydbom A, Lindh Ch. H, Jönsson B, Thelin A, Rylander L. High levels of vitamin D associated with less ischemic heart disease -a nested case-control study among rural men in Sweden. Ann Agric Environ Med. 2017; 24(2): 288-293. AbstractIntroduction and objective. Low levels of serum vitamin D have been associated with increased occurrence of ischemic heart disease (IHD), but findings are inconsistent, e.g. seasonal variation is not always considered in the analyses. The aim of this study was to investigate whether vitamin D is associated with IHD among rural middle-aged men in Sweden when seasonal variation is taken into account. Materials and method. A nested case-control study was performed within a population-based cohort of Swedish farmers and rural residents followed for 20 years. Outcomes were from national health registers. For 276 cases (IHD at any time during follow-up), and for 276 aged-matched controls free of cardiovascular diseases or diabetes, serum levels of vitamin D (25-hydroxyvitamin D 3 ) were analyzed with liquid chromatography/tandem mass spectrometry (LC/MS/MS), in stored blood samples drawn at the baseline survey in 1990-91. The odds ratio (OR) with 95% confidence intervals (CI) of IHD for vitamin D-quartiles (based on measured as well as adjusted for month of sampling) was evaluated in logistic regression models; potential confounders were taken into account. Results. The measured mean vitamin D levels were 27.6 ng/ml(standard deviation (sd)8.2 ng/ml) and 28.8 ng/ml (sd 9.0) among cases and controls, respectively. Compared to the quartile with the lowest month-adjusted vitamin D levels, the risk of IHD was significantly lower in the highest quartile (OR=0.46, 95% CI 0.25-0.84, p=0.012) in the fully-adjusted model. Conclusion. Rural Swedish men in the highest quartile of serum vitamin D had halved relative risk of IHD, compared to those in the lowest quartile.

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Vitamin D status of middle-aged women at 65–71°N in relation to dietary intake and exposure to ultraviolet radiation

Cited by 164 publications

References 30 publications

The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide

The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide

Vitamin D Intake and the Risk for Pancreatic Cancer in Two Cohort Studies

High levels of vitamin D associated with less ischemic heart disease – a nested case-control study among rural men in Sweden

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