Vitamin D Status of Seminomadic Fulani Men and Women

Glew, Robert H.; Crossey, Michael J.; Polanams, Jup; Okolie, Henry; VanderJagt, Dorothy J.

doi:10.1016/s0027-9684(15)30556-3

Cited by 24 publications

(20 citation statements)

References 27 publications

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“…This was similar to observations in other studies evaluating 25(OH)D levels in HIV individuals. 14–17 Our study findings are also similar to those observed in African settings such as Guinea-Bissau, 18 Ethiopia, 19 Morocco, 20 and Nigeria, 21 where TB patients were found to have low serum 25 (OH)D (Table 3). These studies, together with our own findings, indicate that suboptimal body vitamin D storage is common in African adults, whether healthy or TB-infected.…”

Section: Discussionsupporting

confidence: 87%

Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis

Nansera

Graziano

Friedman

et al. 2011

int j tuberc lung dis

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SUMMARY BACKGROUND Vitamin D increases cathelicidin production, and might alter mortality due to tuberculosis (TB) in human immunodeficiency virus (HIV) co-infection. However, due to abundant sun exposure, vitamin D levels might be excellent among Ugandans with HIV and TB. METHODS We measured 25(OH)D and calcium levels in 50 HIV-negative, 50 HIV-infected and 50 TB-HIV co-infected Ugandan adults. RESULTS Mean ± standard deviation 25(OH)D levels were 26 ± 7 ng/ml in HIV-negative, 28 ± 11 ng/ml in HIV-infected and 24 ± 11 ng/ml in TB-HIV co-infected adults (P > 0.05 all comparisons). Vitamin D deficiency (<12 ng/ml) was present in 10% of the HIV-infected subjects, 12% of the TB-HIV co-infected and none of the healthy controls (P = 0.03 for healthy vs. TB, P > 0.05 for other comparisons); 20% of the healthy controls, 22% of the HIV-positive and 38% of the TB-HIV co-infected subjects (P = 0.047 for healthy vs. TB, P > 0.05 for other comparisons) had suboptimal vitamin D levels (<20 ng/ml). No participant had hypercalcemia. Serum 25(OH)D levels correlated positively with body mass index (r = 0.22, P = 0.03) and serum calcium levels (r = 0.18, P = 0.03). CONCLUSIONS Ugandan HIV-infected adults with and without TB commonly had suboptimal vitamin D levels. Clinical trials are needed to evaluate the effect of vitamin D on health outcomes in HIV-infected patients with low vitamin D levels.

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Section: Discussionsupporting

confidence: 87%

Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis

Nansera

Graziano

Friedman

et al. 2011

int j tuberc lung dis

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“…Regardless of these limitations, we found that more than one half of Zimbabweans with KS-AIDS enrolling in our study had insufficient 25(OH)D. While persons with KS-AIDS may not be representative of the majority of HIV-infected Zimbabweans, the mean 25(OH)D level (75.5 nmol/l) of our population is similar to the weighted mean (84.7 nmol/l) of other African populations with and without HIV infection. 23,24,28–31,47,48 …”

Section: Discussionmentioning

confidence: 99%

Relationship of vitamin D insufficiency to AIDS-associated Kaposi's sarcoma outcomes: retrospective analysis of a prospective clinical trial in Zimbabwe

Erlandson

Gudza

Fiorillo

et al. 2014

International Journal of Infectious Diseases

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Summary Objectives The prevalence of vitamin D insufficiency in Africans with AIDS-associated Kaposi sarcoma (AIDS-KS) and the role of vitamin D in AIDS-KS progression are unknown. We hypothesized that a high prevalence of vitamin D deficiency would be found in Zimbabweans with AIDS-KS and that low baseline vitamin D would correlate with progression of AIDS-KS. Methods Ninety subjects were enrolled in a prospective pilot study investigation of the effect of antiretroviral therapy in the treatment of AIDS-KS in Harare, Zimbabwe. Co-formulated abacavir, lamivudine, and zidovudine was initiated; chemotherapy was provided at the discretion of the provider. Participants were followed for 96 weeks. 25-Hydroxyvitamin D was measured in stored specimens collected at study entry. The relationship between vitamin D and clinical response was described by odds ratio and 95% confidence interval. Results Samples were available for 85 participants; 45 (53%) subjects had inadequate (<75 nmol/l) 25-hydroxyvitamin D. HIV-1 RNA was significantly higher among those with insufficient vitamin D (4.7 vs. 4.5 log, p = 0.04). Tumor response, survival, and KS-IRIS were not associated with vitamin D (p ≥0.3). Conclusions Vitamin D insufficiency was common among Zimbabweans with AIDS-KS but not associated with outcomes after initiation of antiretroviral therapy.

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“…[14] In Nigeria, 83% of Fulani women were reported to by deficient [15] and in the United Arab Emirates (UAE) a study reported 50% of pregnant women being deficient. [16] In Saudi Arabia, a study found 59% of healthy 4 -15-year-old schoolchildren to be deficient and 28% insufficient in vitamin D. [17] Studies in every country in this region reveal significant numbers of individuals with vitamin D insufficiency and deficiency.…”

Section: Prevalence Of Vitamin D Insufficiency In Africa and The Middmentioning

confidence: 99%

“…The following factors have been reported to be associated with vitamin D insufficiency and deficiency in Africa and the Middle East: black race and seasonality in SA children; [14] inactivity; smoking; injectable progestin contraceptive use; high alcohol consumption and diets low in calcium and high in animal protein; phosphorus and sodium intake in SA adults; [18] diets rich in corn and cassava; [19] diets rich in unfortified dairy products in Nigerian adults; [15] fast-food diets in the UAE; [20] women in purdah, [21] traditional or religious dress; [15,21] socioeconomic status in Nigerian adults; [22] exclusive breastfeeding in Nigerian children; [15,20,21] indoor lifestyle in Nigeria; [15,20] chronic disease in Egyptian adults, [23] and adolescent girls in Iran and Saudi Arabia; [24,25] anaemia in a group of adults living in Riyadh, Saudi Arabia; [26] lack of sunlight exposure [16] and body mass index in the UAE. [27] …”

Section: Aetiological Factors For Vitamin D Insufficiency and Deficiementioning

confidence: 99%

Vitamin D deficiency and insufficiency in Africa and the Middle East, despite year-round sunny days

et al. 2015

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Vitamin D Status of Seminomadic Fulani Men and Women

Cited by 24 publications

References 27 publications

Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis

Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis

Relationship of vitamin D insufficiency to AIDS-associated Kaposi's sarcoma outcomes: retrospective analysis of a prospective clinical trial in Zimbabwe

Vitamin D deficiency and insufficiency in Africa and the Middle East, despite year-round sunny days

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