Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge

Matějek, Tomáš; Navrátilová, Martina; Žaloudková, Lenka; Maláková, Jana; Malý, Jan; Skálová, Sylva; Palička, Vladimír

doi:10.1080/14767058.2019.1586873

Cited by 12 publications

(14 citation statements)

References 36 publications

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“…Nephrocalcinosis related to excessive vitamin D status was observed in one patient. A study conducted by Matejek et al [39] described vitamin D status in 81 VLBW infants with a total vitamin D intake of 800-1000 IU. In this study, 59% of preterm newborns at 37 ± 2 weeks of PMA still presented with VDD.…”

Section: Discussionmentioning

confidence: 99%

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Kołodziejczyk-Nowotarska,

Bokiniec,

Seliga-Siwecka

2021

Nutrients

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Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20−80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

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Section: Discussionmentioning

confidence: 99%

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Kołodziejczyk-Nowotarska,

Bokiniec,

Seliga-Siwecka

2021

Nutrients

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“…Defisiensi vitamin D pada ibu hamil dikaitkan dengan kemungkinan diabetes melitus tipe 1, alergi, asma bronkial, dan penurunan massa tulang pada anak, serta risiko osteoporosis dini. 6,16 VITAMIN D DAN KELAHIRAN PREMATUR 13,16 Bayi prematur adalah bayi yang lahir pada usia kehamilan kurang dari 37 minggu. 9 Penentuan usia gestasi pada bayi prematur menggunakan New Ballard Score.…”

Section: Pendahuluanunclassified

Suplementasi Vitamin D pada Bayi Prematur

Corona¹,

Fitriyani²,

Michael³

2022

CDK

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<p>Vitamin D merupakan mikronutrien yang berperan dalam sistem imun, penyerapan kalsium dan pembentukan tulang, sehingga dibutuhkan pada segala usia. Defisiensi vitamin D pada ibu hamil sering terjadi dan berkaitan dengan infeksi neonatus, mortalitas dan morbiditas pada bayi prematur mengingat janin mendapat vitamin D sepenuhnya dari ibu. Prematuritas, nutrisi buruk dan kurangnya paparan terhadap sinar matahari dapat meningkatkan risiko defisiensi vitamin D. Kebanyakan pedoman merekomendasikan asupan vitamin D 400 hingga 1000 IU setiap hari untuk kesehatan tulang pada bayi prematur dengan perhatian khusus pada gangguan hati atau ginjal. Vitamin D dapat diberikan melalui tetes, fortifikasi ASI atau melalui susu formula. Belum ada data perlunya pemeriksaan rutin kadar 25-hidroksivitamin D.</p><p>Vitamin D is a micronutrient with a role in the immune system, calcium absorption, and bone formation. Vitamin D deficiency in pregnancy is common and associated with neonatal infection, mortality, and morbidity in premature infants as a fetus get vitamin D entirely from the mother. Short gestational age, poor nutrition, and lack of exposure to sunlight during hospitalization may contribute to an increased risk of vitamin D deficiency. Most guidelines recommend vitamin D 400 to 1000 IU daily intake for bone health in preterms with special attention in preterms with liver or kidney disorders. Vitamin D may be given via drops, breast milk fortification, or formula milk. There are no data regarding the necessity of routine testing for 25-hydroxyvitamin D levels.</p>

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“…Preterm infants are at high risk of vitamin D deficiency at birth, with observational studies showing a prevalence as high as 90% (13)(14)(15). A part of that deficient state may result from limited vitamin D transfer from the mother.…”

Section: Introductionmentioning

confidence: 99%

Low Vitamin D Levels at Birth and Early Respiratory Outcome in Infants With Gestational Age Less Than 29 Weeks

et al. 2022

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BackgroundVitamin D (VitD) is involved in lung development but its influence on respiratory distress syndrome of extremely preterm (EPT) infants have been little investigated. In this study, we examined the influence of low vitamin D status at birth on early respiratory outcomes of this vulnerable infant population.MethodsCord blood 25(OH)D levels ≤ 75 nmol/L were considered as Low vitamin D levels. Stepwise logistic regression and classification regression-tree analyses were used and the primary outcome was the combined outcome of death or mechanical ventilation need by the end of the first week (death or MV DoL7) as a marker od RDS severity.ResultsThe mean (SD) GA and birth weight were 26 (1.4) weeks and 801 (212) gr, respectively; 81/109 (74%) infants had low 25(OH)D levels. Infants with low VitD levels had 25% higher initial FiO2 levels (p < 0.05) and were more likely to be mechanically ventilated on DoL7 (36 vs. 7%, p < 0.05). Adjusted for gestational age, they had 10-fold higher odds of death or MV DoL7 (p < 0.01). By regression tree analysis, the rate of death or MV DoL7 increased from 18 to 71% in infants with GA < 26 weeks and with cord blood 25(OH)D levels higher and lower than 74 nmol/L, respectively (p < 0.05).ConclusionLow vitamin D levels at birth are associated with early adverse respiratory outcomes in infants with GA less 29 weeks. Further largest studies are needed to confirm this association.

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Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge

Cited by 12 publications

References 36 publications

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Suplementasi Vitamin D pada Bayi Prematur

Low Vitamin D Levels at Birth and Early Respiratory Outcome in Infants With Gestational Age Less Than 29 Weeks

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