Vitamin D status, receptor gene BsmI (A/G) polymorphism and breast cancer in a group of Egyptian females

Elzehery, Rasha; Baiomy, Azza; Hegazy, Mohamed A. A.; Фарес, Рамі; El‐Gilany, Abdel‐Hady; Hegazi, Refaat

doi:10.1016/j.ejmhg.2016.11.003

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…Similarly, various casecontrol studies suggested that the association between VDR polymorphism and risk of breast cancer may depend on race and ethnicity. Furthermore, these studies also showed inconsistent results, some suggesting the association of VDR polymorphism with breast cancer, while others suggested a lack of association (3,19,(24)(25)(26)(27)(28)(29)(30)(31). No association between VDR polymorphisms and breast cancer risk was found, however, modification of this relationship was observed with the menopausal status in Europeans (VDR rs4328262 and rs11168292) and East Asians (VDR rs11168287).…”

Section: Female Reproductive Tract Cancermentioning

confidence: 67%

Vitamin D Receptor Polymorphism and Cancer: An Update

Rai

Abdo

Agrawal

et al. 2017

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Section: Female Reproductive Tract Cancermentioning

confidence: 67%

Vitamin D Receptor Polymorphism and Cancer: An Update

Rai

Abdo

Agrawal

et al. 2017

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“…There are many polymorphic regions in VDR , among which Fok 1, Bsm 1, Apa 1, and Taq 1 are the most extensively studied in American (Hispanic white, nonhispanic white, and Caucasian) and Asians (Iranian and Egyptian) populations. 19 – 24 Attention focuses on the role of single nucleotide polymorphisms (SNPs) in VDR that are associated with the development of a wide range of pathological conditions, including type 2 diabetes mellitus, prostate cancer, and BC 18 – 20 . However, limited studies are available on the Pakistani population.…”

Section: Introductionmentioning

confidence: 99%

Association of low penetrance vitamin D receptor Tru9I (rs757343) gene polymorphism with risk of premenopausal breast cancer

2018

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ObjectiveThe aim of this study was to determine whether a novel polymorphism (Tru9I) in the low penetrance vitamin D receptor (VDR) gene is associated with risk of premenopausal breast cancer (BC).MethodsThis case-control study included 228 patients with BC and 503 healthy women living in Pakistan who were analyzed for the VDR Tru9I (rs757343) single nucleotide polymorphism. BC cases were histopathologically confirmed, and all healthy controls were age-matched with patients (age range, 20–45 years). DNA was extracted, and the polymerase chain reaction and restriction fragment length polymorphism assays were performed.ResultsThe VDR Tru9I polymorphism was not significantly associated with premenopausal BC. However, the risk of BC was associated with the ‘uu’ genotype (odds ratio [OR], 1.141; 95% confidence interval [95% CI], 0.206–6.317). Further, mutant Tru9I was significantly associated with Grade IV carcinoma (OR, 5.36; 95% CI, 1.181–24.338).ConclusionThe VDR Tru9I ‘uu’ genotype may increase the risk of premenopausal BC.

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“…This result contrast with study in Egypt. Elzehery et al (2016) found a significant association between hypovitaminosis D status and metastasis in breast cancer patients (p = 0.009).…”

Section: Characteristics Of Subjectsmentioning

confidence: 94%

Association Between Plasma Vitamin D Level and Metastasis in Breast Cancer.

Hasibuan¹,

Widjaja²,

Siregar³

2018

IJAR

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Background: Metastasis is the leading cause of death in breast cancer. Experimental study found anti-invasive and anti-metastatic effects of vitamin D in cancer cells, but epidemiological studies supporting the anti-invasive and anti-metastatic effects of vitamin D are still inconsistent. The aim of the study was to investigate the association of plasma vitamin D levels and metastasis in breast cancer patients. Methods: A descriptive observational cross sectional study was performed on 50 newly diagnosed breast cancer patients at Adam Malik Hospital Medan. Plasma vitamin D levels were measured using enzyme-linked immunosorbent assay method. Chest x-ray, liver ultrasonography and fine-needle biopsy were performed to find cancer cell rmetastasis. The relationship between plasma vitamin D levels and metastases was analyzed by unpaired t-test. RESULTS: The mean plasma vitamin D levels in patients with positive distant metastatis and in patients with negative distant metastases were 26.900 ± 10.165 ng / ml and 27.561 ± 8.467 ng / ml. There were no association between plasma level vitamin D and metastasis in this study.

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Vitamin D status, receptor gene BsmI (A/G) polymorphism and breast cancer in a group of Egyptian females

Cited by 14 publications

References 34 publications

Vitamin D Receptor Polymorphism and Cancer: An Update

Vitamin D Receptor Polymorphism and Cancer: An Update

Association of low penetrance vitamin D receptor Tru9I (rs757343) gene polymorphism with risk of premenopausal breast cancer

Association Between Plasma Vitamin D Level and Metastasis in Breast Cancer.

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