This review presents the current data on comorbidity in glaucoma patients of different age groups and highlights the problem of increasing the incidence of glaucoma due to the expected increase in life expectancy of the world population. Main factors in the development of comorbidity are chronic infections, inflammation, involutional and systemic metabolic disorders, iatrogenia, social status, ecology, and genetic predisposition. Main morphofunctional causes are damage due to endogenous changes in the aging body, external factors and the consequences of diseases associated with age in elderly people. The process of glaucoma progression often depends not only on the adequacy of the chosen tactics and the choice of medications, but also on concomitant systemic factors, so today the success of therapy is determined by a personalized approach to the patient, taking into account the manifestations of the disease and the totality of concomitant changes in the body as a whole.