Vitamin D<sub>3</sub>metabolites in amniotic fluid in relation with maternal and fetal sera in term pregnancies

Ron, M.; Menczel, J; Schwartz, Lydia; Palti, Z.; Kidroni, Gideon

doi:10.1515/jpme.1987.15.3.282

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Maternal 25OHD crosses the placental barrier and represents the main pool of VD in the fetus. In fact, serum fetal (cord blood) 25OHD levels are on average 25% reduced compared to maternal serum and correlate well with mother 25OHD levels [ 65 , 66 ]; therefore, VD deficiency in the mother could be vertically transmitted to the fetus.…”

Section: Physiological Changes Of 25ohd Calcitriol Dbp and Vdr Dmentioning

confidence: 99%

Regulation of Calcitriol Biosynthesis and Activity: Focus on Gestational Vitamin D Deficiency and Adverse Pregnancy Outcomes

et al. 2015

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Vitamin D has garnered a great deal of attention in recent years due to a global prevalence of vitamin D deficiency associated with an increased risk of a variety of human diseases. Specifically, hypovitaminosis D in pregnant women is highly common and has important implications for the mother and lifelong health of the child, since it has been linked to maternal and child infections, small-for-gestational age, preterm delivery, preeclampsia, gestational diabetes, as well as imprinting on the infant for life chronic diseases. Therefore, factors that regulate vitamin D metabolism are of main importance, especially during pregnancy. The hormonal form and most active metabolite of vitamin D is calcitriol. This hormone mediates its biological effects through a specific nuclear receptor, which is found in many tissues including the placenta. Calcitriol synthesis and degradation depend on the expression and activity of CYP27B1 and CYP24A1 cytochromes, respectively, for which regulation is tissue specific. Among the factors that modify these cytochromes expression and/or activity are calcitriol itself, parathyroid hormone, fibroblast growth factor 23, cytokines, calcium and phosphate. This review provides a current overview on the regulation of vitamin D metabolism, focusing on vitamin D deficiency during gestation and its impact on pregnancy outcomes.

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Section: Physiological Changes Of 25ohd Calcitriol Dbp and Vdr Dmentioning

confidence: 99%

Regulation of Calcitriol Biosynthesis and Activity: Focus on Gestational Vitamin D Deficiency and Adverse Pregnancy Outcomes

et al. 2015

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“…Notably, we detected VD-deficiency in all our cord serum samples, probably due to maternal deficiency, as shown elsewhere [ 59 ]. However, it should be noted that calcidiol levels in cord serum have been reported on average 25% reduced as compared to maternal serum levels [ 60 ]. Unfortunately, a high prevalence of maternal VD deficiency has been reported worldwide [ 61 , 62 ] and has been associated with overall adverse consequences for the mother and offspring [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications

et al. 2021

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Urinary tract infections (UTI) during pregnancy are frequently associated with hypertensive disorders, increasing the risk of perinatal morbidity. Calcitriol, vitamin D3’s most active metabolite, has been involved in blood pressure regulation and prevention of UTIs, partially through modulating vasoactive peptides and antimicrobial peptides, like cathelicidin. However, nothing is known regarding the interplay between placental calcitriol, cathelicidin, and maternal blood pressure in UTI-complicated pregnancies. Here, we analyzed the correlation between these parameters in pregnant women with UTI and with normal pregnancy (NP). Umbilical venous serum calcitriol and its precursor calcidiol were significantly elevated in UTI. Regardless of newborn’s sex, we found strong negative correlations between calcitriol and maternal systolic and diastolic blood pressure in the UTI cohort (p < 0.002). In NP, this relationship was observed only in female-carrying mothers. UTI-female placentas showed higher expression of cathelicidin and CYP27B1, the calcitriol activating-enzyme, compared to male and NP samples. Accordingly, cord-serum calcitriol from UTI-female neonates negatively correlated with maternal bacteriuria. Cathelicidin gene expression positively correlated with gestational age in UTI and with newborn anthropometric parameters. Our results suggest that vitamin D deficiency might predispose to maternal cardiovascular risk and perinatal infections especially in male-carrying pregnancies, probably due to lower placental CYP27B1 and cathelicidin expression.

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“…Though the measurement of vitamin D is predominantly performed on blood samples obtained by venipuncture in clinical practice (for diagnostic/therapeutic purposes), for research purposes, vitamin D is measured in other biological matrices, such as urine [ 41 ], tissues [ 52 , 53 ], tissue culture cells, umbilical cord blood [ 54 , 55 , 56 ], finger-prick blood [ 57 ], amniotic fluid [ 58 , 59 ], breastmilk [ 38 ], and synovial fluid [ 19 ]. Table 1 lists vitamin D metabolites that have been detected in different biological matrices in a wide concentration range from a few picograms to dozens of nanograms per milliliter of liquid sample.…”

Section: Vitamin D Determinationmentioning

confidence: 99%

Vitamin D: Current Challenges between the Laboratory and Clinical Practice

Máčová

Bičı́ková

2021

Nutrients

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Vitamin D is a micronutrient with pleiotropic effects in humans. Due to sedentary lifestyles and increasing time spent indoors, a growing body of research is revealing that vitamin D deficiency is a global problem. Despite the routine measurement of vitamin D in clinical laboratories and many years of efforts, methods of vitamin D analysis have yet to be standardized and are burdened with significant difficulties. This review summarizes several key analytical and clinical challenges that accompany the current methods for measuring vitamin D. According to an external quality assessment, methods and laboratories still produce a high degree of variability. Structurally similar metabolites are a source of significant interference. Furthermore, there is still no consensus on the normal values of vitamin D in a healthy population. These and other problems discussed herein can be a source of inconsistency in the results of research studies.

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Vitamin D₃metabolites in amniotic fluid in relation with maternal and fetal sera in term pregnancies

Cited by 6 publications

References 28 publications

Regulation of Calcitriol Biosynthesis and Activity: Focus on Gestational Vitamin D Deficiency and Adverse Pregnancy Outcomes

Regulation of Calcitriol Biosynthesis and Activity: Focus on Gestational Vitamin D Deficiency and Adverse Pregnancy Outcomes

Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications

Vitamin D: Current Challenges between the Laboratory and Clinical Practice

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Vitamin D3metabolites in amniotic fluid in relation with maternal and fetal sera in term pregnancies

Cited by 6 publications

References 28 publications

Regulation of Calcitriol Biosynthesis and Activity: Focus on Gestational Vitamin D Deficiency and Adverse Pregnancy Outcomes

Regulation of Calcitriol Biosynthesis and Activity: Focus on Gestational Vitamin D Deficiency and Adverse Pregnancy Outcomes

Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications

Vitamin D: Current Challenges between the Laboratory and Clinical Practice

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Vitamin D₃metabolites in amniotic fluid in relation with maternal and fetal sera in term pregnancies