Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases

Franco, André Silva; Freitas, Thiago Quadrante; Bernardo, Wanderley Marques; Pereira, Rosa Maria Rodrigues

doi:10.1097/md.0000000000007024

Cited by 76 publications

(63 citation statements)

References 53 publications

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“…Previous studies of the relation among disease activity and vitamin D levels in RA participants demonstrated conflicting findings [19]. Our study demonstrated that serum vitamin D concentrations were not connected with disease activity, its individual objective and subjective components, inflammatory markers, RF and anti-CCP seropositivity, and radiological damage scores.…”

Section: Discussioncontrasting

confidence: 68%

“…In countries near equator, where humans synthesize vitamin D on their skin for longer periods during the year, the low incidence of rheumatic disease prompted to research the role of vitamin D on the existence of rheumatic diseases [19]. Besides, an experimental study in 1998 showed that vitamin D receptor agonists reduced disease expression and worsening of arthritis [20].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Uçkun

Yurdakul

Kılıçarslan

et al. 2018

Archives of Clinical and Experimental Medicine

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In this study, our aims were to identify vitamin D levels in rheumatoid arthritis (RA) individuals as compared to controls and the impact of vitamin D levels on both objective and subjective assessments in RA patients. Methods: The current study was a prospective case-control study conducted on 108 RA patients and 50 agegender matched healthy controls. We first compared the levels of vitamin D among the RA patients and controls. Demographic and clinical data, parameters of disease activity, inflammatory markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity and radiological damage scores were recorded in RA patients. These patients were also demanded to complete RA Quality of Life Questionnaire (RAQoL), fatigue severity scale (FSS) and Health Assessment Questionnaire (HAQ). Results: D vitamin levels in RA patients were significantly lower than healthy controls (p=0.001). Vitamin D deficiency was determined in 73% of the RA patients and 52% of the controls. Vitamin D deficiency was not associated with disease activity (p=0.862). There was no significant relationship among vitamin D levels and all subjective and objective assessments (p>0.05 for all). Conclusion: Vitamin D deficiency was common in RA participants than normal population. However, it was not shown that there was a significant relationship between vitamin D levels and objective and subjective assessments of disease, including disease activity, inflammatory markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity, radiological damage scores, RAQoL, FSS and HAQ.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Uçkun

Yurdakul

Kılıçarslan

et al. 2018

Archives of Clinical and Experimental Medicine

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“…Contradictory to these findings, a study in the Indian population observed improvement in RA disease activity following treatment with loading dose of vitamin D . A meta‐analysis performed for RA reported that an insignificant reduction in RA recurrence was seen after vitamin D supplementation in two studies while there was no statistical significance in DAS28 reduction in another two studies …”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D on disease activity and serum interleukin‐6 in rheumatoid arthritis

Gopal

Thevarajah

et al. 2019

Int J of Rheum Dis

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Aim Vitamin D3 or 25(OH)D3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro‐inflammatory cytokines including interleukin‐6 (IL‐6). The aim of this study is to determine the clinical factors of vitamin D deficiency in multi‐ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL‐6 levels. Method One hundred RA patients and 50 healthy controls, sex‐ and age‐matched, were recruited. Disease Activity Score of 28 joints and Health Assessment Questionnaire scores were assessed. Baseline serum 25(OH)D3 and IL‐6 were measured in all subjects. RA patients who were vitamin D deficient were given loading doses of vitamin D3 and repeated assessments were done. Results Vitamin D deficiency (<50 nmol/L) was found in 63% of RA patients and 76% of healthy controls. Chinese RA patients and healthy controls had significantly more sufficient 25(OH)D3 levels compared to Malays and Indians (P < 0.001). Serum 25(OH)D3 level was still negatively associated with body mass index in RA patients (P = 0.002) after adjustment for potential confounding variables. No significant association was seen between 25(OH)D3 levels and disease activity or serum IL‐6 levels in both pre‐ and post‐treatment groups. A negative association was observed between serum 25(OH)D3 and functional disability, including a 33% improvement post‐treatment (mean ± SD: 0.30 ± 0.46 to 0.20 ± 0.18). Conclusion Vitamin D deficiency is prevalent in Malaysian RA patients. This study suggests that vitamin D is not associated with disease activity or serum IL‐6 levels but it may have a role in functional disability in RA patients.

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“…Varenna, et al reported that vitamin D supplementation may be recommended for RA patients for the prevention and treatment of osteoporosis as well as for its possible effects on disease activity [44]. Franco, et al concluded in a meta-analysis that vitamin D supplementation could possibly reduce rheumatoid arthritis recurrence [45].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

Borukar¹,

Chogle²,

Deo³

2017

J Rheum Dis Treat

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Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases

Abstract: Supplemental Digital Content is available in the text

Cited by 76 publications

References 53 publications

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Effects of vitamin D on disease activity and serum interleukin‐6 in rheumatoid arthritis

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

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