Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial

Zittermann, Armin; Ernst, Jana B.; Prokop, Sylvana; Fuchs, U; Dreier, Jens; Kühn, Joachim; Knabbe, Cornelius; Berthold, Heiner K.; Gouni‐Berthold, Ioanna; Gummert, Jan; Börgermann, Jochen; Pilz, Stefan

doi:10.1007/s00394-018-1666-5

Cited by 15 publications

(15 citation statements)

References 27 publications

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“…The included studies comprised 1,061 participants who were male. Most of the studies were conducted in European countries (Lerchbaum et al, ; Heijboer et al, ; Jorde et al, ; Lerchbaum et al, ; Pilz et al, ; Zittermann et al, ). Five studies included healthy participants living independently, except for three studies involving patients with heart disease (Schroten et al, ; Zittermann et al, ) and included subjects living in nursing homes (Chel, Wijnhoven, Smit, Ooms, & Lips, ).…”

Section: Resultsmentioning

confidence: 99%

“…Change in TT concentration after vitamin D supplementation was assessed in eight studies containing 10 effect sizes with 1,061 participants (Heijboer et al, ; Jorde et al, ; Lerchbaum et al, ; Lerchbaum et al, ; Pilz et al, ; Saha & Goswami, ; Scholten et al, ; Zittermann et al, ). The overall effect of meta‐analysis showed no significant effect of vitamin D on TT (WMD = 0.20, 95% CI: −0.20, 0.60, p = 0.336), and heterogeneity ( I 2 = 0.0%, p = 0.508) was not observed among the studies (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies with 843 participants (Lerchbaum et al, ; Jorde et al, ; Lerchbaum et al, ; Pilz et al, ; Saha & Goswami, ; Zittermann et al, ) were considered for assessing the effect of vitamin D supplementation on SHBG. The overall results showed no significant effect of vitamin D on SHBG (MD = 1.56, 95% CI: −0.85–3.97, p = 0.204), although with substantial heterogeneity ( I 2 = 79.90%, p = 0.000; Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Heterogeneity was observed in the selected studies, considering the effect of vitamin D on SHBG ( I 2 = 79.90%; p heterogeneity = 0.000). Given the high vitamin D3 dose (4,000 IU daily) for 3 years in Zittermman et al's study (Zittermann et al, ) in comparison with another study, the sensitive analysis was performed by examining the impact of one trial on the overall effect. When the trial of Zittermman et al was removed, heterogeneity plummeted ( I 2 = 42.6%; p heterogeneity = 0.137; Table ), suggesting that this trial was the main source of heterogeneity in SHBG.…”

Section: Resultsmentioning

confidence: 99%

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The effect of vitamin D supplementation on the androgenic profile in men: A systematic review and meta‐analysis of clinical trials

et al. 2019

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The aim of this systematic review and meta‐analysis was to evaluate the effect of vitamin D supplementation on total testosterone (TT) and sex hormone‐binding globulin (SHBG) in men. We searched PubMed, Scopus and Web of Science for randomized, controlled trials of vitamin D supplementation in men ≥18 years old up to September 2018, without language restrictions. Meta‐analysis was based on a random effects model. The systematic review was registered as CRD42018094498. We identified 3,402 articles, of which eight studies with 10 effect sizes met the inclusion criteria. Vitamin D daily dose equivalents ranged from 600 to 4,000 per day to 60,000 IU per week; duration was 6 weeks to 36 months. In general, vitamin D supplementation had no significant effect on TT (MD = 0.20, 95% CI: −0.20, 0.60, p = 0.336) and SHBG (MD = 1.56, 95% CI: −0.85, 3.97, p = 0.204). Subgroup analysis conducted with duration of prescription, type (daily or weekly), dosing frequency and baseline vitamin D and TT concentration showed that vitamin D did not significantly affect TT. The present study did not find any evidence to support beneficial effect of vitamin D supplementation on TT and SHBG in men. Thus, further large‐scale randomised controlled trials are required to evaluate the effects of vitamin D supplementation on androgen in men.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The effect of vitamin D supplementation on the androgenic profile in men: A systematic review and meta‐analysis of clinical trials

et al. 2019

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“…Nine studies assessed effects of vitamin D on relevant outcomes [116,[123][124][125][126][127][128][129][130] but no studies assessed effects on androstenediol, androstenedione, dihydrotestosterone, estriol, or DHEAS. Vitamin D doses varied from 100 IU [130], through 1000 IU [125], 4000 IU [129], 20,000 IU [128] up to 40,000 IU [123], and one was unclear [126]. Baseline vitamin D status was low in some trials [128,129], normal in some [127] and unknown in others [123,124].…”

Section: Vitamin Dmentioning

confidence: 99%

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

et al. 2020

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Observational research suggests that micronutrients may be protective for sarcopenia, a key health issue during ageing, potentially via effects on hormone synthesis and metabolism. We aimed to carry out a systematic review of RCTs investigating effects of increasing dietary or supplemental micronutrient intake on sex hormones and IGF-1 in individuals aged 45 years or older. We searched MEDLINE, EMBASE and Cochrane databases for RCTs reporting the effects of different micronutrients (vitamins A, C, D, or E; carotenoids; iron; copper; zinc; magnesium; selenium; and potassium) on sex hormones or IGF-1. Of the 26 RCTs identified, nine examined effects of vitamin D, nine of multi-nutrients, four of carotenoids, two of selenium, one of zinc, and one of vitamin E. For IGF-1 increasing vitamin D (MD: −0.53 nmol/L, 95% CI: −1.58, 0.52), multi-nutrients (MD: 0.60 nmol/L, 95% CI −1.12 to 2.33) and carotenoids (MD −1.32 nmol/L; 95% CI −2.76 to 0.11) had no significant effect on circulating concentrations. No significant effects on sex hormones of other micronutrients were found, but data were very limited. All trials had significant methodological limitations making effects of micronutrient supplementation on sex hormones unclear. Further high quality RCTs with physiological doses of micronutrients in people with low baseline intakes or circulating concentrations, using robust methodology, are required to assess effects of supplementation adequately.

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Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial

et al. 2018

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PurposeIt has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.MethodsThe Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition.ResultsNinety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables.ConclusionVitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels.

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Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial

Abstract: In male patients with advanced HF and low 25OHD concentrations, a daily vitamin D supplement of 4000 IU for 3 years did not prevent the decline in testosterone indices.

Cited by 15 publications

References 27 publications

The effect of vitamin D supplementation on the androgenic profile in men: A systematic review and meta‐analysis of clinical trials

The effect of vitamin D supplementation on the androgenic profile in men: A systematic review and meta‐analysis of clinical trials

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial

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