Vitamin D supplementation for autoimmune hepatitis: A need for further investigation

Sergi, Consolato

doi:10.4254/wjh.v14.i1.295

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…Noticeably, several other supplements have been reported for AIH treatment previously. For example, Vitamin D supplementation may alleviate the interface hepatitis in AIH patients, and influence advanced liver fibrosis, as well as the need for liver transplantation [ 16 ]. It also has been shown that zinc supplementation could safely and efficiently improve mental impairment caused by continuous treatment with corticosteroids in patients with AIH [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model

Lei,

Chen,

Wang

et al. 2024

Exp. Anim.

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The incidence of autoimmune hepatitis (AIH) has increased significantly worldwide.The present study aims to explore the protective effect of L-lysine supplementation against AIH and to investigate its potential underlying mechanisms. A chronic experimental AIH mouse model was established by repeated tail vein injection of human cytochrome P450 2D6 (CYP2D6) plasmid. Starting from day 14 of the modeling, mice in the CYP2D6-AIH +L-lysine group were given 200 μl of purified water containing 10 mg/kg L-lysine by gavage until day27, once a day, and mice in the healthy control group and model group were given an equal volume of purified water by gavage.Our results showed that L-lysine supplementation partially reversed the liver injury mediated by CYP2D6 overexpression. These effects were consistent with the restraining impacts of L-lysine supplementation on decreasing pro-inflammatory cytokines expression level and CD4 + and CD8 + T lymphocytes infiltration, as well as curbing hepatic oxidative stress. Furthermore, L-lysine supplement relieved liver fibrosis in the context of AIH. In conclusion, L-lysine supplementation attenuates CYP2D6-induced immune liver injury in mice, which may serve as a novel nutrition support approach for AIH.

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Section: Discussionmentioning

confidence: 99%

L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model

Lei,

Chen,

Wang

et al. 2024

Exp. Anim.

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“…There is increasing evidence of a link between low vitamin D levels and autoimmunity. In autoimmune hepatitis (AIH), a deficiency of 25(OH)D3 (less than 10 ng/mL) has been associated with severe inflammatory activity of the liver or interface hepatitis, progressive liver fibrosis, and treatment failure [ 100 ].…”

Section: Possible Mechanisms Of the Association Between Vitamin D–vdr...mentioning

confidence: 99%

“…Vitamin D supplementation in patients with AIH has been advocated [ 100 ] because it has been demonstrated that circulating 25-hydroxyvitamin D levels are low in the majority of patients with AIH and that they have an increased nonresponse rate to steroids compared with healthy individuals [ 103 ]. Vitamin D supplementation has been shown to reduce inflammation and limit liver injury in patients with AIH, acting mainly as an antioxidant [ 104 ].…”

Section: Possible Mechanisms Of the Association Between Vitamin D–vdr...mentioning

confidence: 99%

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Αγγελετοπούλου

Thomopoulos

Mouzaki

et al. 2022

IJMS

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There is consistent evidence that vitamin D deficiency is strongly associated with liver dysfunction, disease severity, and poor prognosis in patients with liver disease. Vitamin D and its receptor (VDR) contribute to the regulation of innate and adaptive immune responses. The presence of genetic variants of vitamin D- and VDR-associated genes has been associated with liver disease progression. In our recent work, we summarized the progress in understanding the molecular mechanisms involved in vitamin D–VDR signaling and discussed the functional significance of VDR signaling in specific cell populations in liver disease. The current review focuses on the complex interaction between immune and liver cells in the maintenance of liver homeostasis and the development of liver injury, the interplay of vitamin D and VDR in the development and outcome of liver disease, the role of vitamin D- and VDR-associated genetic variants in modulating the occurrence and severity of liver disease, and the therapeutic value of vitamin D supplementation in various liver diseases. The association of the vitamin D–VDR complex with liver dysfunction shows great potential for clinical application and supports its use as a prognostic index and diagnostic tool.

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“…Still, it is presumed to have an infectious trigger behind the initialization of the inflammatory process of the liver. In some cases, the cause is a virus, which stimulates an inflammatory response, and vitamin D harboring randomized clinical trials has been promising in addition to immunosuppressive therapy ( Domerecka et al, 2021 ; Sergi, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that molecular mimicry may be the basis of several autoimmune reactions in the human body. Due to its molecular mimicry, the antibodies against the SARS-CoV-2 spike protein may disclose a high affinity for several human proteins and trigger autoimmune phenomena ( Sergi, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

COVID-19 vaccination-related autoimmune hepatitis—a perspective

Sergi

2023

Front. Pharmacol.

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Autoimmune hepatitis (AIH) is the inflammation of the liver with clear-cut interface hepatitis and piecemeal necrosis located at the boundary between portal areas and periportal hepatocytes, and characterized by autoimmunity to hepatocytes with an increase in the antinuclear antibody. After the disastrous SARS-CoV-2 pandemic flagellated several countries, several vaccines have been commercialized and have become a ground for social responsibility. The mRNA vaccines, issued by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273), do not use prebuilt viruses to supply the antigen in the subject’s body and are not perfect but have been useful in tackling the pandemic. Nevertheless, both myocarditis and AIH have been reported as side effects of the vaccination programs in addition to thromboembolic events. Here, we explore this topic and give a data-based perspective, gathering a comparison between the titin protein of the sarcomere and myocarditis. The isolation of a Drosophila gene using the serum from a patient with autoimmune scleroderma recognized an epitope on chromosomes (condensed mitotic form) in both human cultured cells and early Drosophila embryos. It revealed that this gene encodes a Drosophila homolog of the vertebrate titin (D-Titin). Moreover, anti-titin antibodies have been found in a subset of patients with myasthenia gravis, a neuromuscular junction disease that is mostly associated with autoimmune antibodies, such as the anti-acetylcholine receptor antibody. The co-existence of myasthenia gravis and autoimmune hepatitis is rare, and a cohort of patients with myasthenia gravis anti-titin antibodies seems to be highly relevant. In consideration of these data and the number of patients who may not be symptomatic, we postulated that autoimmune phenomena may not be exceedingly rare, following the administration of mRNA technology-based vaccines, and a balance between pros and cons in administrating boosters is critical.

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Vitamin D supplementation for autoimmune hepatitis: A need for further investigation

Cited by 4 publications

References 34 publications

L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model

L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

COVID-19 vaccination-related autoimmune hepatitis—a perspective

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