Vitamin D supplementation for irritable bowel syndrome: Concerns about the meta‐analysis

Abuelazm, Mohamed; Abdelazeem, Basel

doi:10.1111/jgh.15883

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…To clarify, they miss-extracted the data of Williams et al [31] by changing the values of IBS-Qol outcome numbers from negative to positive changing the direction of the effect of the Williams et al [31] study and their pooled analysis. We clarified the methodological flaws of Chong et al [55] in our recently published editorial [59]. In another recent review by Haung et al [60], vitamin D was effective in improving IBS-SSS which is also contradictory to our findings.…”

Section: Discussioncontrasting

confidence: 52%

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abuelazm

Shoaib²,

Gamal

et al. 2022

Nutrients

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Irritable bowel syndrome (IBS), a gastrointestinal disorder affecting 7–12% of the population, is characterized by abdominal pain, bloating, and alternating bowel patterns. Data on risk and protective influences have yielded conflicting evidence on the effects of alternative interventions, such as vitamin D. This review focuses on the effects of vitamin D on IBS. A systematic review and meta-analysis considered all articles published until 4 April 2022. The search for randomized controlled trials assessing vitamin D efficacy in IBS with outcomes, primary (Irritable Bowel Severity Scoring System (IBS-SSS)) and secondary (IBS quality of life (IBS-QoL) and serum level of calcifediol (25(OH)D)), was performed on six databases, Google Scholar, Web of Science, SCOPUS, EMBASE, PubMed (MEDLINE), and Cochrane Central Register of Controlled Trials. We included six trials with 616 patients. The pooled analysis found no difference between vitamin D and placebo in improving IBS-SSS (MD: −45.82 with 95% CI [−93.62, 1.98], p = 0.06). However, the pooled analysis favored vitamin D over placebo in improving the IBS-Qol (MD: 6.19 with 95% CI [0.35, 12.03], p = 0.04) and serum 25(OH)D (MD: 25.2 with 95% CI [18.41, 31.98], p = 0.00001). Therefore, further clinical trials are required to reach clinically applicable and generalizable findings.

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Section: Discussioncontrasting

confidence: 52%

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abuelazm

Shoaib²,

Gamal

et al. 2022

Nutrients

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“…To clarify, a recently published systematic review and meta-analysis that included the previously mentioned missed studies yielded different findings regarding the IBS severity scoring system (IBS-SSS) [5]. Another review that also included the missed article yielded consistent IBS-SSS findings [6]; however, its results have been under debate due to statistical concerns [7]. In addition, the narrow search strategy that leads to missing multiple key publications in the pooled analysis is a serious limitation of systematic reviews that have been previously emphasized [8,9].…”

Section: Dear Editormentioning

confidence: 99%

The efficacy of vitamin D supplementation for irritable bowel syndrome: narrow scope and GRADE miss-interpretation

Abuelazm

Abdelazeem

2023

Nutr J

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We read the article by Haung et al. that pooled the effects of vitamin D on irritable bowel syndrome symptoms and associated quality of life. However, the current review suffers from some methodological errors: inadequate search strategy; the grading of recommendations assessment, development, and evaluation (GRADE) miss-assessment; and miss-interpretation. Accordingly, addressing the emphasized limitations will lead to more robust findings and conclusions.

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Vitamin D supplementation for irritable bowel syndrome: Concerns about the meta‐analysis

Cited by 2 publications

References 11 publications

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The efficacy of vitamin D supplementation for irritable bowel syndrome: narrow scope and GRADE miss-interpretation

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