Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis

Cheema, Huzaifa Ahmad; Fatima, Maurish; Shahid, Abia; Bouaddi, Oumnia; Elgenidy, Anas; Rehman, Aqeeb Ur; Kacimi, Salah Eddine Oussama; Hasan, Mohammad Mehedi; Lee, Ka Yiu

doi:10.1016/j.heliyon.2022.e11290

Cited by 6 publications

(27 citation statements)

References 40 publications

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“…The full texts of 49 papers were evaluated in detail, including 41 articles in the main search and eight articles in the citation search. After all reviews, 59 reports from 35 papers [12][13][14][18][19][20][21][22][23][24] that ultimately met the inclusion criteria were included in the meta-metaanalysis. The included (Table S6) and excluded meta-analyses and the reasons for excluding the removed studies are summarized in Supp.…”

Section: Search Resultsmentioning

confidence: 99%

“…So that, in a meta-analysis of randomized controlled trials (RCTs) carried out by Goulão et al [18], which included 18,808 participants, it was reported that there was no evidence that Vit-D intake alone reduced cancer incidence or cancer related deaths, even after long-term follow-up results were included (risk ratio (RR) = 1.03, 95% CI: 0.91-1.15, p > 0.05). Similarly, two recent meta-analyses evaluating Vit-D intake and cancer risk reported that Vit-D intake did not decrease the overall cancer incidence (RR = 0.99, %95 CI: 0.94-1.04, p > 0.05; RR = 0.98, %95 CI: 0.94-1.02, p > 0.05) [19,20]. In contrast to the previously specified meta-analyses, several metaanalyses that incorporated observational epidemiological studies found an association between high Vit-D intake or high serum 25(OH)D levels and a decreased risk of different types of cancer.…”

Section: Introductionmentioning

confidence: 88%

“…A total of 35 eligible meta-analyses [12][13][14][18][19][20][21][22][23][24] examining the association between Vit-D and cancer incidence and/or mortality as well as reporting risk for cancer incidence and/or mortality were included in the current study. The sample sizes of the studies varied between 1,902 and 1,566,662.…”

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

“…The sample sizes of the studies varied between 1,902 and 1,566,662. Of these meta-analyses, 20 studies [12][13][14]18,21,22,36,37,40,42,[44][45][46][47][48]53,54,57,59,60] reported risk for total cancer and various cancer types, three studies [49,50,52] reported mortality, and 12 studies [19,20,23,24,38,39,41,43,51,55,56,58] reported both mortality and risk. In eight meta-analyses [18,19,20,39,41,56,58,60], the primary studies consisted of RCTs.…”

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

“…Of these meta-analyses, 20 studies [12][13][14]18,21,22,36,37,40,42,[44][45][46][47][48]53,54,57,59,60] reported risk for total cancer and various cancer types, three studies [49,50,52] reported mortality, and 12 studies [19,20,23,24,38,39,41,43,51,55,56,58] reported both mortality and risk. In eight meta-analyses [18,19,20,39,41,56,58,60], the primary studies consisted of RCTs. One of these metaanalyses reported breast cancer-related risk [60], while other studies documented total cancer incidence and/or mortality.…”

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

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<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

Arayıcı¹,

Başbınar²,

Ellıdokuz³

2023

Preprint

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It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose of this paper was to elucidate the effects of Vit-D intake and serum 25-hydroxyvitamin-D (25(OH)D) levels on cancer incidence and mortality, the current evidence in this field, and the biases of this evidence using the meta-meta-analysis method. Meta-analyses focusing on Vit-D intake, serum 25(OH)D levels, and cancer risk/mortality were identified. A structured computer literature search was performed in PubMed/Medline, Web of Science (WoS), and Scopus electronic databases using predetermined keyword combinations. Primary and secondary meta-meta-analyses were carried out, combining odds ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) for outcomes reported in selected meta-analyses. A total of 35 eligible meta-analyses assessing the association between Vit-D and cancer incidence and/or mortality were included in this study. In the pooled analysis, higher Vit-D intake and serum 25(OH)D levels were associated with lower cancer risk (OR = 0.93, 95% CI: 0.90-0.96, p < 0.001; OR = 0.80, 95% CI: 0.72-0.89, p < 0.001, respectively) and cancer-related mortality (RR = 0.89, 95% CI: 0.86-0.93, p < 0.001; RR = 0.67, 95% CI: 0.58-0.78, p < 0.001, respectively). When meta-analyses whose primary reports included only randomized controlled trials were pooled, there was no significant association between Vit-D intake and cancer risk (OR = 0.99, 95% CI: 0.97-1.01, p = 0.320). In subgroup analysis, Vit-D consumption was associated with a significant decrease in colorectal and lung cancer incidence (OR = 0.89, 95% CI: 0.83-0.96, p = 0.002; OR = 0.88, 95% CI: 0.83-0.94, p < 0.001, respectively). Taken together, both Vit-D intake and higher 25(OH)D levels may provide remarkable benefits in terms of cancer incidence and mortality, however, careful evaluation according to cancer types is critically important and recommended.

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Section: Search Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

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<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

Arayıcı¹,

Başbınar²,

Ellıdokuz³

2023

Preprint

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Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action

Talib,

Ahmed Jum’AH,

Attallah

et al. 2024

Front. Nutr.

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Cancer, a leading global cause of mortality, arises from intricate interactions between genetic and environmental factors, fueling uncontrolled cell growth. Amidst existing treatment limitations, vitamins have emerged as promising candidates for cancer prevention and treatment. This review focuses on Vitamins A, C, E, and D because of their protective activity against various types of cancer. They are essential as human metabolic coenzymes. Through a critical exploration of preclinical and clinical studies via PubMed and Google Scholar, the impact of these vitamins on cancer therapy was analyzed, unraveling their complicated mechanisms of action. Interestingly, vitamins impact immune function, antioxidant defense, inflammation, and epigenetic regulation, potentially enhancing outcomes by influencing cell behavior and countering stress and DNA damage. Encouraging clinical trial results have been observed; however, further well-controlled studies are imperative to validate their effectiveness, determine optimal dosages, and formulate comprehensive cancer prevention and treatment strategies. Personalized supplementation strategies, informed by medical expertise, are pivotal for optimal outcomes in both clinical and preclinical contexts. Nevertheless, conclusive evidence regarding the efficacy of vitamins in cancer prevention and treatment is still pending, urging further research and exploration in this compelling area of study.

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Milk: A Nutritive and Healthy Food? Consumer Perspective from French and Portuguese Participants

Bréjon,

Tavares,

Florença

et al. 2024

Applied Sciences

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Milk from different animals is a staple food consumed since immemorial times all over the world. However, there is a lack of knowledge in the scientific literature about knowledge related to milk and its effects on nutrition and health. The objective of this study was to investigate consumers’ knowledge about milk, its composition, and its effects on human health in two different countries. The study was conducted through a questionnaire survey in Portugal and France and involved 542 participants of whom 332 were French and 210 were Portuguese. For data analysis, we used basic statistics, parametric tests, tree classification, and factor analysis. The results showed that some sociodemographic variables significantly influenced the level of knowledge, namely country (p < 0.001), age (p = 0.029), and the dimension of the household (p < 0.001). Nevertheless, tree classification analyses revealed that other variables such as education, occupation, and body mass index showed some discriminating ability. Factor analysis retained 20 items of the 23 initially tested. The solution contained five factors, two of which had very good internal consistency (alpha values of 0.825 and 0.803). The mean scores for knowledge in practically all factors were consistently higher for the Portuguese as compared with the French sample. In conclusion, the level of knowledge about milk composition and its health effects differs according to several sociodemographic variables, particularly in what constitutes country differences.

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Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis

Cited by 6 publications

References 40 publications

<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action

Milk: A Nutritive and Healthy Food? Consumer Perspective from French and Portuguese Participants

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