Vitamin D Supplementation Improves Fasting Insulin Levels and HDL Cholesterol in Infertile Men

Holt, Rune; Pedersen, Jørgen; Dinsdale, Elsa; Knop, Filip K.; Juul, Anders; Jørgensen, Niels; Jensen, Martin Blomberg

doi:10.1210/clinem/dgab667

Cited by 13 publications

(14 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5·2 pmol/l; P < 0·001) and higher serum ionised Ca (1·21 mmol/l v . 1·20 mmol/l; P = 0·010) compared with 138 placebo-treated men, as reported previously (10,12) . Moreover, there were no differences in weight, BMI or body fat mass (%) after the intervention between the two groups (12) .…”

Section: Resultssupporting

confidence: 85%

“…All participants were instructed not to consume vitamin D supplements > 400 mg daily during the trial. In this cohort, we have previously reported that BMI correlates with serum 25OHD and serum parathyroid hormone (PTH), and serum 25OHD was significantly higher and serum PTH was significantly lower in men with normal weight compared with men with overweight and obesity (12) .…”

Section: Methodsmentioning

confidence: 86%

See 1 more Smart Citation

High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

Holt,

Jorsal,

Yahyavi

et al. 2023

Br J Nutr

Self Cite

View full text Add to dashboard Cite

Obesity is associated with low vitamin D status and the optimal supplement and dosage of cholecalciferol (vitamin D3) or calcidiol (25OHD) for individuals with obesity has been debated. We aimed to determine the effect of high-dose vitamin D3 supplementation on achieving adequate vitamin D levels among infertile men with normal weight versus obesity. Here, we present secondary endpoints from a single-center, double-blinded, randomized clinical trial, comprising of 307 infertile men randomized to active or placebo treatment for 150 days. Men in the active group initially received an oral bolus of 300,000 IU vitamin D3, followed by daily supplementation with 1,400 IU vitamin D3 and 500 mg calcium. Baseline body mass index (BMI) was listed as a predefined subgroup. At baseline, serum 25OHD was significantly higher in men with normal weight (BMI < 25 kg/m2) compared with men with overweight (BMI 25-30 kg/m2) and obesity (BMI > 30 kg/m2) (48 nmol/L vs. 45 nmol/L and 39 nmol/L, respectively; p = 0.024). After the intervention, both men with normal weight, overweight and obesity treated with vitamin D3 had a significantly higher serum 25OHD compared with corresponding placebo-treated men (BMI < 25 kg/m2: 92 nmol/L vs. 53 nmol/L, BMI = 25-30 kg/m2: 87 nmol/L vs. 49 nmol/L and BMI > 30 kg/m2: 85 nmol/L vs. 48 nmol/L; p < 0.001 for all respectively). In conclusion, we show high-dose vitamin D3 supplementation to infertile men with obesity and low vitamin D status, is sufficient to achieve adequate serum 25OHD levels.

show abstract

Section: Resultssupporting

confidence: 85%

Section: Methodsmentioning

confidence: 86%

High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

Holt,

Jorsal,

Yahyavi

et al. 2023

Br J Nutr

Self Cite

View full text Add to dashboard Cite

show abstract

“…Two double-blind, randomized, placebo-controlled trials showed that vitamin D supplementation, which increased the mean 25(OH)D concentrations to Ͼ40 ng/mL, could increase insulin secretion capacity and improve peripheral insulin sensitivity in patients with type 2 diabetes and individuals at high risk of diabetes (15,16). As shown in a doubleblinded, randomized, clinical trial, infertile men receiving vitamin D supplementation had lower fasting serum insulin concentrations, lower homeostasis model assessment of insulin resistance (HOMA-IR) index and higher high-density lipoprotein cholesterol (HDL-C) levels compared with the placebo group (17). A multicenter, single-blind, randomized clinical trial in patients with COVID-19 pneumonia revealed higher levels of anti-in-fl ammatory cytokine IL-10 and CD4 ϩ T cells in the patients allocated to supplementation with 10,000 IU/d vitamin D (with the mean 25(OH)D level of 29Ϯ 7 ng/ mL) than in those who received 2,000 IU/d vitamin D (with the mean 25(OH)D level of 19Ϯ 9 ng/mL).…”

Section: Discussionmentioning

confidence: 99%

High Vitamin D Level in Female Mice Increases the Number of Live Fetuses

Liu

Yang

et al. 2023

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Little is known about the impact of high-normal range of 25-hydroxyvitamin D [25(OH)D] on reproductive function. The aim of this study was to investigate the effect of different dose vitamin D supplementation in female mice on the pregnancy outcomes. Three groups of female mice were fed with fodder containing different dose of vitamin D at both pre-gestational and gestational stages. Serum 25(OH)D and calcium concentrations were monitored. The expression levels of vitamin D receptor (VDR) mRNA and protein in placenta were determined by real-time RT-PCR and western blot. Pregnancy outcomes were evaluated and compared among the three groups. Compared with the medium and low dose groups, serum 25(OH)D concentration was signifi cantly increased and approximated to high-normal range in the high dose group (pre-gestational: 81.3Ϯ5.75 vs 52.8Ϯ6.24 and 25.0Ϯ3.99 ng/mL; gestational: 86.8Ϯ5.99 vs 52.6Ϯ9.29 and 27.9Ϯ4.96 ng/mL, respectively; all pϽ0.001). Interestingly, the average number of live fetuses per litter was much larger in the high dose group than in other two groups (19.8Ϯ5.31 vs 13.8Ϯ1.30 and 12.8Ϯ3.55 respectively, both pϽ0.05). However, no signifi cant differences of the expression levels of VDR mRNA and protein in placenta were identifi ed among the three groups. Supplementation of high dose vitamin D can enhance the female mice reproductive function. Further study is warranted to explore the mechanism by which high level of 25(OH)D in female mice increases the number of fetuses.

show abstract

“…Independently of other factors, vitamin D deficiency contributes to type 2 diabetes, insulin resistance, and metabolic syndrome [91,92]. Other than the genetic vulnerability, those confounding factors are not as proximal as vitamin D deficiency as a cause for COVID-19 and its complications [93].…”

Section: More Scientific Evidence Would Model Vitamin D's Contributio...mentioning

confidence: 99%

Logical Analysis of Response of Health Officials’ Worldwide, to Cost-Effective Early Remedies for COVID19

Wimalawansa¹,

Polonowita²

2022

Preprint

View full text Add to dashboard Cite

With the advent of COVID19, the attitude of health authorities around the world, led mainly by the West, demanded a level of proof as evidence for cheap, non-patented remedies while promoting expensive, patented, and untested remedies by using emergency use authorization and special provisions afforded to the status of a pandemic emergency. Western science has neither a tested nor a valid historical basis of a logical system that informs to authenticate scientific practices. Here we use a logical heuristic derived from ancient Buddhist logic, which is consistent with the conduct of modern science. We applied the heuristic to show that enough evidence was available for using cost-effective early therapies such as vitamin D supplementation as a public health measure during the first half of 2020. Strong supporting evidence has since accumulated. Apart from political and financial decisions incompatible with science and other conflicts of interest, a critical barrier to evaluating and approving early therapies appears to be the fallacy that the randomized controlled trial (RCT) is the superior proof method in medical hypotheses, including those for nutrients. Logically, no reason exists why properly designed retrospective, ecological, and naturalistic studies with adequate sample sizes and applied appropriate statistical methods would not be as valid as RCTs, especially when elucidating a causative factor instead of treatment. That assertion is particularly true for nutrient deficiencies, interventions, and other cost-effective therapies. Leading health authorities’ failure or refusal to consider other study types (because of either poor logic or vested interest) probably contributed to the spread of misinformation, symptomatic disease, complications, and deaths from COVID19. Partial immunity derived from vaccines and the later development of more contagious variants—and thus a sense of acceptance that SARS-CoV-2 had progressed from a pandemic to an endemic—shows the hollowness of the initial promotions and mandates of vaccines as a cure. Adequate knowledge was available in 2020 to advise that SARS-CoV-2 will continue to mutate, with variants emerging a few times per year, making the vaccine less effective. Emerging evidence confirms that natural immunity better protects against new variants than vaccination against the spike protein. Had vitamin D been adopted as part of the public health measure through a broader supplementation program in 2020 or even today (through sun exposure or as a prophylactic or adjunct therapy early on), the viral spread and symptomatic disease may have been suppressed, with minimal lockdowns and quarantine, and economic harm. The pandemic could have been halted with a significantly reduced need for hospitalization, complications, and deaths, potentially saving millions of lives.

show abstract

Vitamin D Supplementation Improves Fasting Insulin Levels and HDL Cholesterol in Infertile Men

Cited by 13 publications

References 35 publications

High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

High Vitamin D Level in Female Mice Increases the Number of Live Fetuses

Logical Analysis of Response of Health Officials’ Worldwide, to Cost-Effective Early Remedies for COVID19

Contact Info

Product

Resources

About