Vitamin D supplementation improves neuromuscular function in older people who fall

Dhesi, Jugdeep; Jackson, Stephen; Bearne, Lindsay; Moniz, Caje; Hurley, Michael; Swift, Cameron; Allain, Theresa J.

doi:10.1093/ageing/afh209

Cited by 362 publications

(281 citation statements)

References 33 publications

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“…In addition to disruption of the bone formation, there is an increased tendency to fall and risk of fracture due to weakness in proximal muscles and impaired neuromuscular co-ordination, which affect quality of life negatively as pain and functional restriction. In several previous studies, a relationship has been shown between vitamin D and physical performance and disability [17,18].…”

Section: Introductionmentioning

confidence: 88%

“…Previous studies have shown a relationship between vitamin D and physical performance and disability [17,18]. In a study by Başaran et al, which examined the effect of vitamin D level on quality of life by questioning physical and social functions in sub groups, the vitamin D levels were found to be much worse compared to normal individuals [65].…”

Section: Vitamin D and Quality Of Lifementioning

confidence: 99%

See 1 more Smart Citation

The Relationship between Vitamin D and Quality of Life in Patients with Fibromyalgia Syndrome

Yıldırım¹,

Yıldırım²

2015

Med-Science

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Section: Introductionmentioning

confidence: 88%

Section: Vitamin D and Quality Of Lifementioning

confidence: 99%

The Relationship between Vitamin D and Quality of Life in Patients with Fibromyalgia Syndrome

Yıldırım¹,

Yıldırım²

2015

Med-Science

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“…7 The pharmacokinetics, biochemical effects, efficacy and safety of a single high-dose oral or injectable cholecalciferol has been evaluated and found to be effective safe, and well tolerated. [10][11][12][13][14] There are several unanswered questions regarding the use of different pharmaceutical forms of vitamin D. Because of lack of headto-head comparative studies, it is unclear whether treatment given orally or by injection would be better effective. In order to provide answer to these uncertainties, we carried out head-to-head comparison of same dosage of vitamin D administered by oral and injectable routes of treatment, in achieving normal serum 25OHD level, and assess various ot her biochemical parameters that support adequacy of serum vitamin D levels.…”

Section: Original Articlementioning

confidence: 99%

Vitamin D supplementation therapy – comparison of efficacy of three different protocols

Harinarayan¹,

Srinivasa²,

Thennarasu³

et al. 2015

J Clin Sci Res

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Background: To study the efficacy of vitamin D supplementation therapy with three different protocols. Methods:In protocols 1 (intensive) and 3 (standard) oral cholecalciferol was given 60,000 IU/week/8 weeks followed bimonthly for 12 weeks. In protocol 2 parenteral-bolus cholecalciferol was given as 600,000 IU loading dose, 8 weeks later followed by cholecalciferol 60,000IU bimonthly for 12 weeks. Elemental calcium (1 g/day) was administered for full duration of study in all three protocols. Serum albumin, calcium, phosphorous, alkaline phosphatase, 25-hydroxy vitamin D (25OHD) and parathyroid hormone were tested at baseline, at 2 nd , and 5 th months. Statistical analysis was performed using random measures analysis of variance. As patients receiving protocol 3 were significantly older compared to the other two groups, age-adjusted analysis was carried out.Results: Intention-to-treat and per-protocol analysis showed that patients receiving protocol 2 had achieved 25OHD sufficiency levels at 8 weeks suggesting that protocol 2 appeared to perform best among the three protocols. However, these differences were not sustained at 5 months suggesting the need for continuing supervision. Conclusions:Despite varied responses of different biochemical markers, all three protocols were effective in bringing up 25OHD levels. However, protocol 2 performed the best among the three protocols. Our observation also highlight the importance of need for ongoing supplementation and continuing supervision of the same.

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“…Vitamin D appears to play an important role in neuromuscular function as well as bone density. 27 Meta-analyses have demonstrated that vitamin D supplementation of 700-1,000 IU daily may reduce the risk of falls in the elderly by about 20%, that the effect is achieved in the short term (on the order of 2-5 months), and that the benefit persists for up to 36 months. 28,29 …”

Section: Screening Elderly Patients For the Presence Of Common Geriatmentioning

confidence: 99%

Ten ways to improve the care of elderly patients in the hospital

Labella

Merel

Phelan

2011

Journal of Hospital Medicine

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Hospitalists care for elderly patients daily, but few have specialized training in geriatric medicine. Elderly patients, and in particular the very old and the frail elderly, are at high risk of functional decline and iatrogenic complications during hospitalization. Other challenges in caring for this patient population include dosing medications safely, preventing delirium and accidental falls, and providing adequate pain control. Ways to improve the care of the hospitalized elderly patient include the following: screening for geriatric syndromes such as delirium, assessing functional status and maintaining mobility, and implementation of interventions that have been shown to prevent delirium, accidental falls, and acute functional decline in the hospital. This article addresses these issues with 10 evidence‐based pearls developed to help hospitalists provide optimal care for this expanding population. Journal of Hospital Medicine 2011;6:351–357. © 2011 Society of Hospital Medicine

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Vitamin D supplementation improves neuromuscular function in older people who fall

Cited by 362 publications

References 33 publications

The Relationship between Vitamin D and Quality of Life in Patients with Fibromyalgia Syndrome

The Relationship between Vitamin D and Quality of Life in Patients with Fibromyalgia Syndrome

Vitamin D supplementation therapy – comparison of efficacy of three different protocols

Ten ways to improve the care of elderly patients in the hospital

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