Vitamin D supplementation in children with asthma: a systematic review and meta-analysis

Fares, Maan; Alkhaled, Lina; Mroueh, Salman; Akl, Elie A.

doi:10.1186/s13104-014-0961-3

Cited by 34 publications

(25 citation statements)

References 23 publications

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“…In addition, children are sedentary with more screen time and less time spent outdoors, have a higher BMI, both of which have been associated with asthma . Together, the composite investigation of these myriad factors and the influence of Western lifestyle will allow an improved understanding of the mechanisms that underlie the inconclusive results of vitamin D supplementation . Hence, future studies are needed to better define the individual or combined role of inflammation, metabolic dysregulation, gut microbiome, and vitamin D bioavailability in the association between vitamin D deficiency and pediatric asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings define a new mechanism that may underlie pediatric obesity‐related asthma, a mechanism that may be amenable to supplementation and dietary modification. Given the inconclusive results on the effectiveness of vitamin D supplementation in improving asthma outcomes and pulmonary function, perhaps additional analyses of these studies based on the participant BMI may identify differential effects of vitamin D supplementation among obese children with asthma.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D and pulmonary function in obese asthmatic children

et al. 2016

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Summary Objective Asthma-related morbidity is higher among children with vitamin D deficiency and obesity, morbidities that frequently co-exist among minority children. However, the effect of co-existent obesity and vitamin D deficiency on pulmonary function is poorly understood. Methods We compared percent-predicted values of pulmonary function across vitamin D categories among 72 obese and 71 normal-weight Hispanic and African-American children with asthma recruited at an urban children’s hospital. Serum cytokines associated with Th1 and Th2 inflammation and 25-hydroxyvitamin D (25-OHD) were quantified in fasting serum. 25-OHD levels ≥30 ng/ml were categorized as sufficient, <30 and ≥20 ng/ml as insufficient, and <20 ng/ml as deficient. The role of inflammation was investigated by regression analysis. Results Vitamin D deficiency was present in 50% of children and did not differ by obese status. Forced Expiratory Volume in the first second (84.5 ± 9.4 vs. 94.8 ± 8.4, P<0.001), and Functional Residual Capacity (67.5 ± 20.1 vs. 79.3 ± 19, P=0.01) were lower among vitamin D deficient obese asthmatics than their sufficient counterparts, and Total Lung Capacity was lower than their insufficient counterparts (86.9 ± 14.3 vs. 96.6 ± 10, P=0.01); similar associations were not observed in normal-weight asthmatics and were not influenced by systemic inflammation. No association between Th1 and Th2 inflammatory measures, vitamin D deficiency, and pulmonary function tests was found. Conclusions Vitamin D deficiency was associated with pulmonary function deficits among obese children, but not among normal-weight children with asthma, an association that was independent of Th1 and Th2 serum inflammatory measures. Vitamin D deficiency may be one potential mechanism underlying the obese-asthma phenotype.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vitamin D and pulmonary function in obese asthmatic children

et al. 2016

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“…Indeed, many RCTs of vitamin D supplementation to improve asthma control and exacerbations have been completed and these studies have reported a mixture of positive and negative results. However, several meta-analyses show that vitamin D supplementation significantly reduced the rate of severe exacerbations in patients with asthma [109][110][111][112][113]. Whether these effects are only observed in patients with vitamin D deficiency, as was shown in COPD, is less clear since only two studies performed subgroups analysis, showing conflicting results [112,113].…”

Section: Vitamin D In Asthma Exacerbationmentioning

confidence: 99%

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

et al. 2019

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Patients with respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or asthma often experience an acute worsening of respiratory symptoms, termed exacerbations. Although the course of exacerbations is disease specific, they are mostly triggered by a respiratory infection. Exacerbations often require hospitalization and are an important cause of mortality. Treatments of exacerbations aim to minimize the negative impact and to prevent subsequent events. Despite many existing therapy options, many patients do not benefit from therapy and suffer from recurrent events. Vitamin D deficiency is a worldwide problem and is extremely prevalent in these patients. Vitamin D, known for its calcemic effects, also has immunomodulatory and anti-infectious actions and can therefore be a possible agent to treat or prevent exacerbations. This review will focus on vitamin D as a potential candidate to treat or prevent exacerbations in CF, COPD, and asthma.

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“…In our search for SRs on vitamin D and asthma risk, we identified 18 articles [38,[67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83] of which 10 reported data on cohort studies [67][68][69][70][71][72][73][74][75][76] and eight reported data on RCTs [38,[77][78][79][80][81][82][83] ( Supplemental Table S2-S5 and Figure S1). Out of the 18 SRs, 14 were restricted to children [67,[69][70][71][72][73][74][75][76][77][78][79]…”

Section: Resultsmentioning

confidence: 99%

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maretzke¹,

Bechthold²,

Egert

et al. 2020

Nutrients

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Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.

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Vitamin D supplementation in children with asthma: a systematic review and meta-analysis

Cited by 34 publications

References 23 publications

Vitamin D and pulmonary function in obese asthmatic children

Vitamin D and pulmonary function in obese asthmatic children

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

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