Vitamin D supplementation in obese Sri Lankan children: a randomized controlled trial

Samaranayake, Dulani; Adikaram, S G S; Kendaragama, K. M. D. L. D.; Senevirathne, J. T. N.; Jayasekera, Heather; Wickramasinghe, Pujitha

doi:10.1186/s12887-020-02329-w

Cited by 14 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, obese individuals have been noted to have vitamin D deficiency. Vitamin D is an essential nutrient that plays an important role in calcium homeostasis [55]. In a paediatric population, an association between low vitamin D level and activation of pro-inflammatory pathways among the obese has been identified [56].…”

Section: Discussionmentioning

confidence: 99%

Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

Deng

Yang

Jin-li

et al. 2021

IJERPH

View full text Add to dashboard Cite

Background: Bone mass acquisition during growth is a major determinant of the risk of developing osteoporosis later in life. Body composition is an anthropometric determinant of bone mineral density (BMD) and significantly influences its development during childhood and adolescence. Objective: This study aimed to systematically examine the association between body composition and bone mineral density in children and adolescents. Methods: Observational studies addressing this association were identified from PubMed (MEDLINE), Embase, Scopus and the Cochrane Library (up to January 2021). The study populations consisted of healthy children and adolescents. The DerSimonian and Laird method was used to compute pooled estimates of effect size and the respective 95% confidence intervals for upper limbs, femoral neck (FN), lumbar spine (LS) and total body, respectively. Subgroup analyses were further performed based on age, sex and ethnicity. Results: Thirty-one published studies were eligible for inclusion in this systematic review and meta-analysis, including three longitudinal studies. The combined population from all the studies amounted to 21,393 (11,205 males and 10,188 females). The pooled estimates of the correlation coefficients for lean mass (LM) and BMD ranged from 0.53 to 0.74 (p < 0.050), and the pooled regression coefficients ranged from 0.23 to 0.79 for FN, LS and total body (p < 0.050). For fat mass (FM), the pooled correlation coefficients ranged from 0.10 to 0.50 (p < 0.050) and the pooled regression coefficient was only significant for FN BMD with a weak strength (pooled β = 0.07, p < 0.050). The pooled regression coefficients for body fat percentage (BF%) were between −0.54 and −0.04 (p < 0.050). The subgroup analysis revealed a stronger association in Asians than in Caucasians for LM and in males compared to females for BF% (p < 0.050). Conclusions: This systematic review and meta-analysis supports a positive association between LM and BMD. BF% appears to have a deleterious effect on bone acquisition in children and adolescents.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

Deng

Yang

Jin-li

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…The overall RoB for all the six RCTs on hypercalcaemia among children and adolescents was considered moderate (Tier 2) (Asghari et al 2021;Belenchia et al 2013;Lewis et al 2013;Maalouf et al 2008;Rajakumar et al 2020;Samaranayake et al 2020) (Table 5). All three key domains raised concern regarding RoB;…”

Section: Hypercalcaemia Among Children and Adolescentsmentioning

confidence: 99%

“…Four RCTs included only overweight or obese children (Asghari et al 2021;Belenchia et al 2013;Rajakumar et al 2020;Samaranayake et al 2020), while BMI status was unclear in two RCTs (Lewis et al 2013;Maalouf et al 2008). The mean baseline S-25(OH)D concentrations were between 25 to 49 nmol/L in five RCTs (Asghari et al 2021;Belenchia et al 2013;Maalouf et al 2008;Rajakumar et al 2020;Samaranayake et al 2020) and between 50 to 74 nmol/L in one RCT (Lewis et al 2013).…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Preparatory work for the update of the tolerable upper intake levels for vitamin D

Lamberg‐Allardt

Adebayo

Peltonen

et al. 2023

EFSA Supporting Publications

View full text Add to dashboard Cite

This technical report describes the collection of data and appraisal of scientific evidence in relation to the assessment of Tolerable Upper Intake Levels (UL) for vitamin D. Five systematic reviews (SR) were conducted following a tailored literature search, data extraction, evidence appraisal (i.e., risk of bias (RoB) assessment) and evidence synthesis. Narrative reviews were conducted to gather contextual evidence relevant to the interpretation of the main body of evidence (BoE). In the SR on bioavailability of calcidiol compared to native vitamin D3, 4304 records were identified and reduced to 12 individual records after screening for eligibility. The evidence appraisal revealed an overall low to high RoB of the individual studies. The available BoE demonstrated higher relative bioavailability of calcidiol compared to native vitamin D3 with a conversion factor of about 2 across baseline 25(OH)D concentrations of 30 to 55 nmol/L. In the SR on hypercalcaemia and hypercalciuria, 8277 records were identified and reduced to 37 individual records after screening for eligibility. The evidence appraisal revealed an overall low to high RoB of the individual studies. The available evidence demonstrated that occurrence of persistent hypercalcemia and hypercalciuria with high doses of vitamin D supplementation was rare. Nevertheless, increased risk of persistent hypercalciuria was observed with 250 μg/d of vitamin D supplementation. In the SRs on bone fractures, falls, bone mineral density (BMD), bone mineral content, and bone strength, 15 541 records were identified and reduced to 20 individual records after screening for eligibility. The evidence appraisal revealed an overall low to moderate RoB of the individual studies. No clear signs of adverse effects of high vitamin D intake were found in relation to bone fractures, falls, or areal BMD, but volumetric BMD was reduced with 100 and 250 μg/d of vitamin D.

show abstract

“…Although weight loss is associated with increased circulating 25(OH)D levels (69, 70), the reciprocal beneficial effect of vitamin D status on body fat mass remains controversial among clinical studies. Some clinical trials have reported that native vitamin D supplementation favorizes weight loss, body fat mass reduction and metabolic profile in obese adult (154) and pediatric (155,156) population, while in other studies no related difference on weight loss was observed in obese subjects assigned to receive daily native vitamin D (157). Therefore, the effect of native vitamin D supplementation on successfully body fat mass reduction remains unclear, with a total insignificant effect reported by some (158,159) but not all meta-analysis studies (160).…”

Section: Impact Of Mineral Homeostasis On Fat Mass and Adipokine Profile In General Populationmentioning

confidence: 99%

Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease

et al. 2021

View full text Add to dashboard Cite

Adipose tissue is nowadays considered as a major endocrine organ, which apart from controlling lipid metabolism, displays a significant role in energy expenditure, food intake and in the regulation of various systemic physiological processes. Adipose derived pro-inflammatory cytokines and adipokines, particularly leptin and adiponectin, provide inter-communication of adipose tissue with various metabolic pathways, ultimately resulting in a complex network of interconnected organ systems. Recent clinical and experimental research has been focused on exploring the direct interaction between adipokine profile and elements of mineral metabolism, including parathormone (PTH), fibroblast growth factor-23 (FGF23) and calcitriol. The emerging crosstalk between adipose tissue and calcium and phosphorus homeostasis suggests that metabolic disorders from one system may directly affect the other and vice versa. It is current knowledge that fat metabolism disturbance, commonly encountered in obese individuals, influences the expression of calciotriopic hormones in general population, while various clinical trials attempting to successfully achieve body fat loss by modulating mineral profile have been published. In chronic kidney disease (CKD) state, there is an increasing evidence suggesting that mineral disorders, influence adipose tissue and linked endocrine function. On the contrary, the impact of disturbed fat metabolism on CKD related mineral disorders has been also evocated in clinical studies. Recognizing the pathogenetic mechanisms of communication between adipose tissue and mineral balance is critical for understanding the effects of metabolic perturbations from the one system to the other and for identifying possible therapeutic targets in case of disrupted homeostasis in one of the two connected systems. To that end, this review aims to enlighten the recent advances regarding the interplay between mineral metabolism, fat mass and adipokine profile, based on in vitro, in vivo and clinical studies, in general population and in the course of CKD.

show abstract

Vitamin D supplementation in obese Sri Lankan children: a randomized controlled trial

Cited by 14 publications

References 32 publications

Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

Preparatory work for the update of the tolerable upper intake levels for vitamin D

Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease

Contact Info

Product

Resources

About