Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

Hoseini, Zahra; Behpoor, Naser; Hoseini, Rastegar

doi:10.5812/modernc.92490

Cited by 3 publications

(4 citation statements)

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“…Our findings in HFD + STZ rats provide direct evidence for the antidiabetic role of AT and Vit D supplementation as suspected before 19 , 23 . Our results suggest that weight, visceral fat, and the ratio of liver to body weight decreased in D + AT + HD, D + AT + MD, D + AT + oil, D + HD, and D + MD compared to the D + C group, confirming previous findings 20 , 24 .…”

Section: Discussionsupporting

confidence: 72%

“…The HFD consisted of a mixture of standard mouse food powder (365 mg/kg), mixed vitamins and minerals (60 mg/kg), yeast powder (1 mg/kg), sheep fat (310 mg/kg), DL-methionine (3 mg/kg), and sodium chloride (1 mg/kg) in pellet form, which was purchased from Beh-Parvar Company. This specific diet has been shown in previous studies to induce obesity in rats 19 , 20 . After a weight gain of over 300 g, the rats were divided into two main groups: sham (non-diabetic control, n = 8) and diabetic (n = 48).…”

Section: Methodsmentioning

confidence: 81%

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Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM

Hoseini,

Behpour,

Hoseini

2024

Sci Rep

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Dysregulation of key transcription factors involved in hepatic energy metabolism, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and liver X receptor alpha (LXRα), has been observed in T2DM. The present study aims to investigate the effects of aerobic training and vitamin D supplementation on liver enzyme levels and the levels of PGC-1α and LXRα proteins in hepatocytes, in a rat model of T2DM. The study involved 56 male Wistar rats, divided into two groups: one was non-diabetic and acted as a control group (n = 8), and the other had induced diabetes (n = 48). The diabetic rats were then split into six subgroups: two groups received high or moderate doses of vitamin D and aerobic training (D + AT + HD and D + AT + MD); two groups received high or moderate doses of vitamin D alone (D + HD and D + MD); one group underwent aerobic training with vehicle (sesame oil; D + AT + oil), and one group was a diabetic control receiving only sesame oil (oil-receiving). The D + AT + HD and D + HD groups received 10,000 IU of vitamin D, while the D + AT + MD and D + MD groups received 5000 IU of vitamin D once a week by injection. The D + AT + oil group and the sham group received sesame oil. After eight weeks of treatment, body weight, BMI, food intake, serum insulin, glucose, 25-hydroxyvitamin D, ALT, AST, and visceral fat were measured. The levels of PGC-1α and LXRα proteins in the liver was assessed by western blotting. Statistical analysis was performed using the paired t-test, one-way analysis of variance (ANOVA), and the Tukey post hoc test at a significance level of P < 0.05. Body weight, food intake, and BMI decreased significantly in the D + AT + HD, D + AT + MD, D + AT + oil, D + HD, and D + MD groups with the highest reduction being observed in body weight and BMI in the D + AT + HD group. The D + AT + HD group exhibited the lowest levels of insulin, glucose, and HOMA-IR while the D + C group exhibited the highest levels among the diabetic groups. The D + AT + HD and D + AT + MD groups had lower levels of ALT and AST enzymes compared to the other groups with no significant difference between D + AT + HD and D + AT + MD. D + AT + HD (p = 0.001), D + AT + MD (p = 0.001), D + HD (p = 0.023), D + MD (p = 0.029), and D + AT + oil (p = 0.011) upregulated LXRα compared to D + C. Among these groups, D + AT + HD exhibited a more profound upregulation of LXRα than D + AT + MD, D + AT + oil, D + HD, and D + MD (p = 0.005; p = 0.002, p = 0.001, and p = 0.001, respectively). Similarly, D + AT + HD showed a more notable upregulation of PGC-1α compared to D + AT + oil, D + HD, and D + MD (p = 0.002; p = 0.001, and p = 0.001, respectively). Pearson correlation tests showed significant and negative correlations between serum 25-hydroxyvitamin levels and both visceral fat (r = − 0.365; p = 0.005) and HOMA-IR (r = − 0.118; p = 0.009); while positive and significant correlations between the liver-to-bodyweight ratio with both ALT and AST enzymes and also between QUICKI levels with LXRα (r = 0.578; p = 0.001) and PGC-1α (r = 0.628; p = 0.001). Combined administration of aerobic training and vitamin D supplementation potentially improves liver enzymes in type-2 diabetic rats that were simultaneous with upregulating the levels of PGC-1α and LXRα proteins in hepatocytes. These improvements were more significant when combining exercise with high-dose vitamin D supplementation. This study highlights the potential of this combination therapy as a new diabetes treatment strategy.

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Section: Discussionsupporting

confidence: 72%

Section: Methodsmentioning

confidence: 81%

Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM

Hoseini,

Behpour,

Hoseini

2024

Sci Rep

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“…Observations in elderly women have also signified the efficiency of adequate PAL in improving cardiovascular factors after an eight-week exercise program (17). Other interventional studies on elderly women receiving physical training for eight weeks have indicated a significant reduction in the BW, BMI, body fat percentage, and WHR (18). Compensatory effects such as favorable changes in the TG level, total HDL cholesterol ratio, and DBP have also been demonstrated in adolescents (19).…”

Section: Discussionmentioning

confidence: 97%

The Association of Physical Activity Level and the Risk Factors of Nonalcoholic Fatty Liver Disease in the Elderly Female Patients

Hoseini

Behpoor

Hoseini

2020

J Kermanshah Univ Med Sci

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Background: Nonalcoholic fatty liver disease (NAFLD) is becoming more prevalent among elderly women. Sedentary lifestyle is an important etiological factor of NAFLD. Objectives: The present study aimed to investigate the association between physical activity level (PAL) and the risk factors of NAFLD in the elderly female patients. Methods: This study was conducted on 40 elderly women with NAFLD, who were aged 62.25 ± 1.97 years, weighed 86.70 ± 3.81 kilograms, and had the body mass index (BMI) of 34.54 ± 2.38 kg/m2. The women were selected from 90 volunteers. The PAL was measured using the rapid assessment of physical activity (RAPA) questionnaire. As the outcomes, we measured anthropometric indices, sitting systolic and diastolic blood pressure, lipid profile, glycemic indices, liver enzymes, and fatty liver grade in the fasting state. The outcome variables were statistically normalized and expressed as mean and standard deviation (SD). The association between the PAL and NAFLD risk factors was evaluated using Pearson’s correlation-coefficient. Results: The risk factors of NAFLD were inversely correlated with the PAL, except for high-density lipoprotein, which was positively correlated with the PAL (r = 0.495; P = 0.001). In addition, low PAL had a significant correlation with a higher fatty liver grade (r = -0.464; P = 0.003), while the PAL was inversely associated with the NAFLD risk factors. Conclusions: According to the results, the PAL and fatty liver grade had a significant correlation, which indicated the potential health benefits of adequate PAL for the elderly women with NAFLD.

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“…Also, the results of this study indicated that six-week Vit D supplementation significantly reduces the alteration of TC, TG, LDL, and HDL following EEE. Previous studies have investigated the effect of long-term vitamin D supplementation on the lipid profile in NAFLD patients [24,25]. However, limited studies have investigated the effect of short-term Vit D supplementation on the EEE-induced alterations in NAFLD patients [26].…”

Section: Discussionmentioning

confidence: 99%

Alterations of liver enzymes and lipid profile in response to exhaustive eccentric exercise: vitamin D supplementation trial in overweight females with non-alcoholic fatty liver disease

2022

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Background Eccentric exhaustive exercise (EEE) training has been known as a promising training modality to enhance performance and stimulate adaptation in healthy individuals or patients that might also cause abnormal liver enzymes and lipid profiles. Vitamin D (Vit D) supplementation is believed to improve the condition of Non-Alcoholic Fatty Liver Disease (NAFLD) patients. However, there is limited evidence on the effect of Vit D supplementation on the EEE-induced alterations. This study aimed to investigate the effect of short-term supplementation of Vit D on the liver enzymes and lipid profile alterations following EEE in overweight women with NAFLD. Methods In this clinical trial, 22 overweight women with NAFLD were randomly divided into experimental and control (n = 11 in each). The experimental group consumed 2000 IU of Vit D per day for six weeks; the control group consumed a lactose placebo daily with the same color, shape, and warmth percentage. Two treadmill EEE sessions were performed before and after the six-week Vit D supplementation. Blood was taken from the antecubital vein to measure the liver enzymes, lipid profile, and Vit D at four stages: Pre 1(before the first EEE session), Post 1(after the first EEE session), Pre 2 (before the second EEE session), and Post 2 (after the second EEE session). Results The results indicate that Vit D supplementation significantly reduced Bodyweight (BW; P = 0.047), Body Mass Index (BMI; P = 0.044), Body Fat Percentage (BFP; P = 0.001), and Waist Hip Ratio (WHR; P = 0.001) in the experimental group. Additionally, the results showed increased liver enzymes (ALT, AST, and GGT) and lipid profile (TC, TG, and LDL) following EEE. While the HDL levels decreased significantly after EEE. Compared with control, the results of the independent t-test showed significantly lower ALT (P = 0.001; P = 0.001), AST (P = 0.001; P = 0.001), and GGT (P = 0.001; P = 0.001); while significantly higher Vit D (P = 0.001, P = 0.001) in the experimental in both Pre 2 and Post 2; receptively. Also, significantly lower TC (P = 0.001; P = 0.001), TG (P = 0.048; P = 0.001), and LDL (P = 0.001; P = 0.001); while significantly higher HDL (P = 0.001, P = 0.001) were observed in the experimental group compared to the control in both Pre 2 and Post 2; receptively. Conclusions Vit D supplementation reduces the liver enzymes and improves lipid profile alterations following EEE in overweight women with NAFLD. Thus, Vit D supplementation can be considered a functional supplement to improve the EEE-induced alteration. Trial registration: The trial was in the Iranian Clinical Trial Registration Center under the (IRCT20201130049538N1) on 05/07/2021.

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Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

Cited by 3 publications

References 37 publications

Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM

Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM

The Association of Physical Activity Level and the Risk Factors of Nonalcoholic Fatty Liver Disease in the Elderly Female Patients

Alterations of liver enzymes and lipid profile in response to exhaustive eccentric exercise: vitamin D supplementation trial in overweight females with non-alcoholic fatty liver disease

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