Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials

Gowda, Usha; Mutowo, Mutsa; Smith, Benjamin John; Wluka, Anita E.; Renzaho, Andre Μ Ν

doi:10.1016/j.nut.2014.06.017

Cited by 179 publications

(150 citation statements)

References 49 publications

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“…In a post hoc analysis stratified by vitamin D status at baseline (sufficient vs deficient), no significant differences between groups were observed [240]. Similarly, Shaffer et al [241] and Gowda et al [242] found no significant differences when comparing studies with mean baseline 25OHD levels below or above 50 nmol/L. For most of the analyses performed, a substantial unexplained heterogeneity was present and the quality of evidence obtained from the included trials was graded as low by the authors [240].…”

Section: Resultsmentioning

confidence: 99%

“…We identified six SRs [239–244] among which four [239–242] provided formal MAs reporting pooled data on results from 30 RCTs on effects of vitamin D supplementation on depression (Table Ha in S1 File). …”

Section: Resultsmentioning

confidence: 99%

“…For most of the analyses performed, a substantial unexplained heterogeneity was present and the quality of evidence obtained from the included trials was graded as low by the authors [240]. Similarly, no overall beneficial effects of vitamin D supplementation were found in the MAs by Shaffer et al (221) and Gowda et al [242] and a substantial and unexplained heterogeneity was also found in most analyses (Table Ha in S1 File). …”

Section: Resultsmentioning

confidence: 99%

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Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data

et al. 2017

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BackgroundA large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic quantitative review on characteristics of randomized clinical trials (RCTs) included in meta-analyses (MAs) on non-skeletal effects of vitamin D supplementation.Methods and findingsWe identified systematic reviews (SR) reporting summary data in terms of MAs of RCTs on selected non-skeletal outcomes. For each outcome, we summarized the results from available SRs and scrutinized included RCTs for a number of predefined characteristics. We identified 54 SRs including data from 210 RCTs. Most MAs as well as the individual RCTs reported null-findings on risk of cardiovascular diseases, type 2 diabetes, weight-loss, and malignant diseases. Beneficial effects of vitamin D supplementation was reported in 1 of 4 MAs on depression, 2 of 9 MAs on blood pressure, 3 of 7 MAs on respiratory tract infections, and 8 of 12 MAs on mortality. Most RCTs have primarily been performed to determine skeletal outcomes, whereas non-skeletal effects have been assessed as secondary outcomes. Only one-third of the RCTs had low level of 25OHD as a criterion for inclusion and a mean baseline 25OHD level below 50 nmol/L was only present in less than half of the analyses.ConclusionsPublished RCTs have mostly been performed in populations without low 25OHD levels. The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data

et al. 2017

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“…Therefore, particularly in the context of the chronic inflammation in MS, vitamin D supplementation might prevent or ameliorate depressive disorder. However, data appear conflicting with respect to the role of vitamin D in depressive disorder in patients with MS [52,246] , and with respect to the benefit of vitamin D supplementation in depression in general [247] . Therefore we used a randomized placebo-controlled trial (RCT) to explore the effect of high dose vitamin D 3 supplementation on depressive symptoms in MS.…”

Section: Sex (F/m)mentioning

confidence: 99%

“…In depressive disorder several RCTs with vitamin D 3 have been conducted, again with conflicting results. Even meta-analyses, assessing largely the same studies, are not unanimous, showing either beneficial effects of vitamin D 3 supplementation on depression or no effect at al l [247,[256][257] . However in some RCTs, as well as in the current study, patients had low depression scores and relatively normal 25(OH)D levels at baseline [241,257] .…”

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confidence: 99%

Mapping the effects of vitamin D in multiple sclerosis

Rolf¹

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Columbus (1451Columbus ( -1506 on one of his four voyages Er zijn verrassend veel parallellen te trekken tussen onderzoek doen en een van mijn favoriete vrijetijdsbestedingen, namelijk koken. Alles begint met een inspiratie, nieuwsgierigheid en een idee. Dan volgt de planning en de uitvoering en na (lang…) wachten kun je het resultaat proeven. Het blijft altijd spannend of het gelukt is en of het wel lekker is. Als het lekker is, dan smaakt het vaak ook naar meer! Zo niet, dan moet je het recept aanpassen, of crucialer, iets heel anders verzinnen...De weg naar een goed gelukt gerecht is, althans voor mij, minstens zo belangrijk: watertandend recepten zoeken en menu's samenstellen, op zoek gaan naar de juiste producten, lekker creatief combineren en (al of niet met succes) uitproberen. Dat kon ook in de voor mij nieuwe keuken van de wetenschap, en wel in een restaurant met een excellente ambiance. Verder is de diversiteit aan smaken, waar ik bij eten zo van houd, zeker ook terug te vinden in de verschillende hoofdstukken.Of kookkunsten gewaardeerd worden is vervolgens een kwestie van smaak, maar ook van kennis. De fijnproevers zullen zich op de details storten en boeren die het niet kennen zullen het niet eten, maar voor iedereen die aan tafel schuift: hopelijk is datgene wat in dit boekje geserveerd wordt smakelijk en levert het gespreksstof op voor het natafelen! Abbreviations and glossary & G L O S S A R Y AB BR EVI ATI ONS 23General IntroductionHistorical explorers discovered new land around the world, and with every journey more details have been added to global maps. For multiple sclerosis research, explorers of the 20 th century put vitamin D on the map, and from 2008 onwards, our research team in Maastricht has tried to add more details to this area. Today, vitamin D in multiple sclerosis is still an active area of research. Many reviews concentrate on the role of vitamin D in multiple sclerosis, illustrated by clinical and immunological studies. Also in this thesis two reviews elaborate on this topic. Therefore, the introduction to this thesis is restricted to the essential players, i.e. multiple sclerosis, its immune pathogenesis, and vitamin D, followed by the outline of the thesis.Multiple sclerosis (MS) is the most common disabling neurological disease among young people. Initial symptoms generally occur in the age of 20-40 years and MS affects women 2-3 times more often compared to men [1][2] . Currently, almost 1 in 1000 people suffers from MS in the Netherlands [3] . MS is characterized by inflammation and neurodegeneration of the central nervous system (CNS; brain and spinal cord). Though, it is still a matter of debate whether it is neurodegenerative or inflammatory from onset [1,4] . Most accepted, however, is the thought that inflammatory processes lead to damage of the fatty myelin sheaths covering the neuronal axons, which normally support fast transduction of signals, and this process is called demyelination. The inflammation can be accompanied by axonal injury and over time this result...

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Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency

et al. 2020

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Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials

Cited by 179 publications

References 49 publications

Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data

Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data

Mapping the effects of vitamin D in multiple sclerosis

Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency

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