Vitamin D Testing—Where Are We and What Is on the Horizon?

Heureux, Nicolas

doi:10.1016/bs.acc.2016.07.002

Cited by 34 publications

(23 citation statements)

References 73 publications

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“…Free or unbound concentrations (C f ) of vitamin D 3 in serum were quantified by ELISA (Free 25OH Vitamin D ELISA; Future Diagnostic Solutions; DIAsource ImmunoAssays®; Belgium) https://www.alpco.com/pdfs/38/38-KARF1991.pdf 26,27 . Total serum concentrations (C tot ) of vitamin D 3 , which is the sum of C f + the concentration bound to serum proteins (C b ), were quantified using the DiaSorin LIAISON vitamin D assay as previously described 25 .…”

Section: Methodsmentioning

confidence: 99%

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Lima

Castro

King

et al. 2018

Annals of Allergy, Asthma & Immunology

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Section: Methodsmentioning

confidence: 99%

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Lima

Castro

King

et al. 2018

Annals of Allergy, Asthma & Immunology

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“…In addition, free 25-OHD could be considered as an independent prognostic biomarker for survival. More recently, many other articles have been published, including reviews and clinical studies, which highlight the importance of free 25-OHD 27 .…”

Section: -Ohd Free In Clinical Studiesmentioning

confidence: 99%

Vitamina D libre: una determinación en aumento

Gómez¹,

Heureux²

2019

Rev Osteoporos Metab Miner

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Vitamin D has long been a familiar concept for any professional working in clinical biology. Nowadays it is becoming known to a large sector of the population. The great research efforts developed over the past decade have led to an explosion in the number of determinations requested of the most qualified metabolite to express the body state of vitamin D, 25-OH vitamin D (25-OHD) free, represents the small fraction not bound to transporter proteins. According to the free hormone hypothesis, it should be considered the best representation of the body state of vitamin D. Unfortunately, limited attention has been paid to this determination since, until recently, the scientific community only had tedious, indirect methods to measure it. A few years ago, a direct measurement method of free 25-OHD was already available to carry out research studies with promising results.

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“…When turnaround times should be minimal the use of automated readily available methods of 25(OH)D testing is certainly preferable to the time-consuming method of LC-MS/MS in clinical routine [13,14]. International standardization of current 25(OH)D immunoassays has reduced previously reported interlaboratory variation [15,16]; however, differences seem to be more prominent in specific populations, such as hemodialysis patients, critically ill individuals or pregnant women [17,18].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D assessment in perioperative medicine and critical care

Zajic

Heschl

Schörghuber

et al. 2019

Wien Klin Wochenschr

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Background There is controversy about the impact of acute illness on vitamin D levels. This study was carried out to assess the influence of perioperative fluid loading on 25-hydroxy-vitamin D [25(OH)D] levels. The study evaluated the clinical utility of a commonly available chemiluminescence assay (ECLIA, IDS-iSYS) and liquid chromatography/mass spectrometry (LC-MS/MS) in the diagnosis of vitamin D deficiency in this setting. Methods In this prospective observational pilot study in adult patients undergoing cardiovascular surgery on cardiopulmonary bypass (CPB), blood samples drawn at preoperative baseline (t1), after weaning from CPB (t2), on intensive care unit (ICU) admission

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Vitamin D Testing—Where Are We and What Is on the Horizon?

Cited by 34 publications

References 73 publications

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Vitamina D libre: una determinación en aumento

Vitamin D assessment in perioperative medicine and critical care

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