Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Dutta, Deep; Sharma, Meha; Aggarwal, Sameer; Mohindra, Ritin; Bhattacharya, Saptarshi; Kalra, Sanjay

doi:10.4103/ijem.ijem_526_19

Cited by 9 publications

(6 citation statements)

References 72 publications

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“…Vitamin D enhances the innate immune response, exerts immunomodulatory properties and moderates cytokines via the VDR, resulting in thyroid damage and dysfunction. 24 At the first stage of thyroid damage, T3 and T4 are released into the serum, resulting in the development of hyperthyroidism. As the extent of thyroid damage, the production of T3 and T4 is inhibited.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus

Quan¹,

Bi²

2023

DMSO

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Purpose It is unknown whether there is an association between 25-hydroxyvitamin D (25(OH)D) level and thyroid disease in postmenopausal women with type 2 diabetes. This study aimed to evaluate the relationship between blood 25(OH)D levels and thyroid function in postmenopausal women with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study involved Chinese postmenopausal women who presented to our diabetes clinic from March 2021 to May 2022 and were diagnosed with T2DM collected via a convenience sampling method. Blood samples were obtained from each patient to detect serum thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and 25(OH)D levels. Deficiency was defined as a 25(OH)D < 20 ng/mL. Comparative analysis was via t -test or chi-square test. Pearson correlation was then used to estimate the relationship between different thyroid function parameters and 25(OH)D. Multivariate logistic regression analysis was used to explore potential risk factors for 25(OH)D deficiency. Results In total, 157 out of 230 participants (68.26%) had 25(OH)D deficiency. Compared with patients with normal 25(OH)D levels, patients with 25(OH)D deficiency had shorter medical histories of diabetes mellitus (DM, p = 0.001) and higher rates of hyperthyroidism ( p = 0.007), hypothyroidism ( p < 0.001), TPOAb positive ( p < 0.001) and TgAb positive ( p < 0.001). Correlation analysis revealed that TSH ( r = −0.144, p = 0.030), FT4 ( r = −0.145, p = 0.029), TPOAb ( r = −0.216, p = 0.001) and TgAb ( r = −0.150, p = 0.024) levels were correlated with serum 25(OH)D levels. Further multivariable logistic regression analyses suggested that the length of DM history, presence of hyperthyroidism, presence of hypothyroidism and positive TPOAb were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM. Conclusion Hyperthyroidism, hypothyroidism and TPOAb positivity were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus

Quan¹,

Bi²

2023

DMSO

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“…The most commonly used therapy in the present study was the combination therapy of vildagliptin and metformin at 50/500 mg dose followed by vildagliptin monotherapy at 50 mg dose. Several real-world studies from India have reported the use of vildagliptin monotherapy (4%-18%) [25,26] and vildagliptin and metformin combination therapy (37%) [27] for the management of T2DM. About 70% of the present study cohort used the twice-daily formulation.…”

Section: Discussionmentioning

confidence: 99%

Data on vildagliptin and vildagliptin plus metformin combination in type-2 diabetes mellitus management

Das¹

2021

Bioinformation

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It is of interest to evaluate the clinical effectiveness and safety of vildagliptin as monotherapy and combination therapy of vildagliptin and metformin for the management of type 2 diabetes mellitus (T2DM) patients in Indian settings. The study included patients with T2DM (aged >18 years) receiving vildagliptin monotherapy and vildagliptin in combination with metformin therapy of various strengths. Data related to demographics, risk factors, medical history, glycated hemoglobin (HbA1c) levels, and medical therapies were retrieved from medical records. Out of 9678 patients (median age, 52.0 years), 59.1% were men. A combination of vildagliptin and metformin (50/500 mg) was the most commonly used therapy (54.8%), and the median duration of therapy was 24.0 months. The predominant reason for selecting vildagliptin therapy was to improve HbA1c levels (87.8%). A total of 87.5% of patients required dosage up-titration. Vildagliptin therapy was used in patients with T2DM and associated complications (peripheral neuropathy, CAD, nephropathy, retinopathy, autonomous neuropathy, stroke/TIA, and peripheral artery disease). Among 5175 patients who experienced body weight changes, a majority of patients had lost weight (68.6%). The target glycemic control was achieved in 95.3% of patients. The mean HbA1c levels were significantly decreased post-treatment (mean change: 1.34%; p<0.001). Adverse events were reported in 0.4% of patients. Physicians rated the majority of patients as good to excellent on the global evaluation of efficacy and tolerability scale (98.9%, each). Vildagliptin with or without metformin was an effective therapy in reducing HbA1c helps in achieving target glycemic control, and was well-tolerated in Indian patients with T2DM continuum.

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“…level of TSH following vitamin D de ciency was considered to stimulate the growth of thyroid cells, causing TNs and thyroid carcinoma [18]. In addition, with the vitamin D receptor and ossifying triol involved [29], vitamin D was related to the regulation of cell differentiation, apoptosis, and in ammation [30], all of which signi cantly contributed to the formation of TNs [31].…”

Section: Potential Mechanisms Of the Associationmentioning

confidence: 99%

How was a sedentary lifestyle associated with the prevalence of thyroid nodules among government staff?

Zhou

Zeng

Zhang

et al. 2023

Preprint

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Purpose A sedentary lifestyle has been an increasing public health issue especially since the outbreak of COVID-19. Limited evidence was reported on the association between sedentary lifestyle and prevalence of thyroid nodules, a benign but prevalent health concern in the modern society. Methods This study used the annual examination data of Guangzhou public officials in 2020. Thyroid nodules were diagnosed following standard criteria. Sedentary lifestyle was self-reported as spending < 2 h, 2 ~ 4 h, 4 ~ 6 h, or > 6 h per day staying sedentary. Multivariate logistic regressions were used to evaluate the association between sedentary lifestyle and thyroid nodules. Results were also stratified by covariates. Results Among 18,023 participants, sedentary lifestyle was positively associated with the prevalence of thyroid nodules, with ORs (95%CIs) of 1.23 (1.05–1.43), 1.69 (1.45–1.96), and 1.74 (1.49–2.03) for those with daily sedentary time of 2 ~ 4h, 4 ~ 6h, >6h compared with < 2h group (P-trend < 0.01). The three estimates (i.e., 1.29, 1.92, and 1.96 respectively) were stronger among the participants with thyroid nodules of TI-RADS-2 stage compared with other groups. Stratified analysis also indicated a modification effect of age, with the estimates for participants aged ≥ 50 being 1.21, 1.79 and 2.00, compared with 1.04, 1.29 and 1.31 among those aged 35 ~ 49, and 1.13, 1.37 and 1.34 among those under 34 years old (P-interaction = 0.012). Conclusions A sedentary lifestyle may be associated with increased prevalence of thyroid nodules among government staff, with the elderly being the most vulnerable. The sedentary lifestyle should be modified to promote their well-being.

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Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Cited by 9 publications

References 72 publications

Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus

Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus

Data on vildagliptin and vildagliptin plus metformin combination in type-2 diabetes mellitus management

How was a sedentary lifestyle associated with the prevalence of thyroid nodules among government staff?

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