Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis

Bhat, Mehrajuddin; Ismail, Azman

doi:10.1016/j.jsbmb.2015.05.012

Cited by 90 publications

(67 citation statements)

References 47 publications

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“…Studies have shown that this vitamin may possess natural antioxidant and anti-inflammatory properties [24,25]. Intensified inflammation was also indicated by the increase in the serum hsCRP and hsIL-6 levels observed in the climbers in the present study, and our findings partially correspond with those of other studies [26–28].…”

Section: Discussionsupporting

confidence: 92%

Serum irisin and myostatin levels after 2 weeks of high-altitude climbing

Śliwicka¹,

Cisoń

Kasprzak³

et al. 2017

PLoS ONE

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Exposure to high-altitude hypoxia causes physiological and metabolic adaptive changes by disturbing homeostasis. Hypoxia-related changes in skeletal muscle affect the closely interconnected energy and regeneration processes. The balance between protein synthesis and degradation in the skeletal muscle is regulated by several molecules such as myostatin, cytokines, vitamin D, and irisin. This study investigates changes in irisin and myostatin levels in male climbers after a 2-week high-altitude expedition, and their association with 25(OH)D and indices of inflammatory processes. The study was performed in 8 men aged between 23 and 31 years, who participated in a 2-week climbing expedition in the Alps. The measurements of body composition and serum concentrations of irisin, myostatin, 25(OH)D, interleukin-6, myoglobin, high-sensitivity C-reactive protein, osteoprotegerin, and high-sensitivity soluble receptor activator of NF-κB ligand (sRANKL) were performed before and after expedition. A 2-week exposure to hypobaric hypoxia caused significant decrease in body mass, body mass index (BMI), free fat mass and irisin, 25-Hydroxyvitamin D levels. On the other hand, significant increase in the levels of myoglobin, high-sensitivity C-reactive protein, interleukin-6, and osteoprotegerin were noted. The observed correlations of irisin with 25(OH)D levels, as well as myostatin levels with inflammatory markers and the OPG/RANKL ratio indicate that these myokines may be involved in the energy-related processes and skeletal muscle regeneration in response to 2-week exposure to hypobaric hypoxia.

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Section: Discussionsupporting

confidence: 92%

Serum irisin and myostatin levels after 2 weeks of high-altitude climbing

Śliwicka¹,

Cisoń

Kasprzak³

et al. 2017

PLoS ONE

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“…Moreover, this data demonstrate that five week vitamin D supplementation increases serum vitamin D concentration in LBP patients and decreases oxidative stress in skeletal muscle (Dzik et al 2018). Similar findings reported increased protein oxidation and nitrosative stress and reduced activities of the antioxidant enzymes (Bhat et al 2015) as well as increased lipid peroxidation in the muscles of vitamin D-deficient rats (Cielen et al 2016). Furthermore, another study indicated that rats treated with vitamin D showed reduced tissue damage and attenuated oxidative stress after exhaustive exercise (Ke et al 2016).…”

Section: Vdr In Musculoskeletal Systemsupporting

confidence: 55%

Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

2019

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PurposeThis review provides a current perspective on the mechanism of vitamin D on skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and muscle energy metabolism. It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency.MethodThe interaction between vitamin D deficiency and mitochondrial function as well as skeletal muscle atrophy signalling pathways have been studied and clarified in the last years. To the best of our knowledge, we summarize key knowledge and knowledge gaps regarding the mechanism(s) of action of vitamin D in skeletal muscle.ResultVitamin D deficiency is associated with oxidative stress in skeletal muscle that influences the mitochondrial function and affects the development of skeletal muscle atrophy. Namely, vitamin D deficiency decreases oxygen consumption rate and induces disruption of mitochondrial function. These deleterious consequences on muscle may be associated through the vitamin D receptor (VDR) action. Moreover, vitamin D deficiency may contribute to the development of muscle atrophy. The possible signalling pathway triggering the expression of Atrogin-1 involves Src-ERK1/2-Akt- FOXO causing protein degradation.ConclusionBased on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.

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“…A recent study showed that vitamin D3 deficiency induces mild oxidative stress in the rat muscle, as observed by increased protein carbonyls and altered antioxidant enzyme activities. Conversely, supplementation with vitamin D3 corrected all of these oxidative stress defects (Bhat and Ismail, 2015). In addition to its role as an regulator of antioxidant functions, SKN-1 plays an important part in maintaining protein homeostasis (Li et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1

et al. 2016

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Summary Vitamin D has multiple roles including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases including Alzheimer’s disease, Parkinson’s disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to examine the mechanism by which vitamin D influences aging. We found that Vitamin D3-induced lifespan extension requires the stress response pathway genes SKN-1, IRE-1, and XBP-1. Vitamin D3 (D3) induced expression of SKN-1 target genes, but not canonical targets of IRE-1/XBP-1. D3 suppressed an important molecular pathology of aging, that of widespread protein insolubility, and prevented toxicity caused by human β-amyloid. Our observation that D3 improves protein homeostasis and slows aging highlights the importance of maintaining appropriate vitamin D serum levels, and may explain why such a wide variety of human age-related diseases are associated with vitamin D deficiency.

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Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis

Cited by 90 publications

References 47 publications

Serum irisin and myostatin levels after 2 weeks of high-altitude climbing

Serum irisin and myostatin levels after 2 weeks of high-altitude climbing

Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1

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