Vitamin D Up-regulates the Vitamin D Receptor by Protecting It from Proteasomal Degradation

Kongsbak-Wismann, Martin; Rode, Anna K. O.; Hansen, Marie M.; Bonefeld, Charlotte M.; Geisler, Carsten

doi:10.1007/978-3-319-99375-1_110

Cited by 1 publication

(1 citation statement)

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“…As VDR is essential in initiating vitamin D function, and vice versa, vitamin D is of paramount importance as it influences the VDR expression directly. Vitamin D has an impact on VDR upregulation by increasing VDR synthesis or decreasing receptor degradation ( 36 , 37 ) Studies showed that vitamin D induced and stabilized the expression of VDR-messenger ribonucleic acid (mRNA) which led to the VDR level increment ( 38 ). The nongenomic effect signaling activation through the membrane bund VDR leads to MAP-kinase stimulation and involves interaction with ion channels, crosstalk with the nuclear VDR, and other transduction pathways.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status, vitamin D receptor, CYP2R1, and CYP24A1 profiles in children

Iriani,

Rachman,

Fatina

et al. 2024

Front. Nutr.

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IntroductionVitamin D plays a major role in the musculoskeletal and immune system. Understanding the comprehensive mechanism of vitamin D receptors and the enzyme of vitamin D induction (CYP2R1) and inhibition (CYP24A1) in its metabolism is interesting. This study aims to understand vitamin D metabolism in Indonesian pediatrics, specifically in Jakarta, which has abundant sun exposure.MethodologyA cross-sectional study with comparative, correlative, and multivariate analysis on vitamin D, vitamin D receptor, CYP2R1, and CYP24A1 levels was conducted on 46 children with no known morbidity.ResultSubjects were mostly male (52.2%), age group of 2–6 years (34.8%), and had sufficient vitamin D status (43.5%, median 27.55 ng/mL). Age was found to have a negative correlation with vitamin D levels (p < 0.001; r = −0.625) and CYP2R1 (p = 0.035; r = −0.311). Significant positive associations were found between CYP24A1 and CYP2R1 (p = 0.046; r = 0.296). Participants aged 0–2 are more likely to have a higher level of vitamin D status compared to those aged >2 years (OR 42.092, 95% CI [4.532–390.914], p = 0.001). VDR levels were significantly lower in insufficient vitamin D levels than in the sufficient group (p = 0.018). VDR and vitamin D status had a positive relation (OR 7.023, 95% CI [1.864–26.453], p = 0.004).ConclusionVitamin D levels decrease with the increase in age. Vitamin D receptor level has an inline-level progression with vitamin D level. CYP2R1 and CYP24A1 suggest a directly proportional relationship. Vitamin D screening and supplementation in children older than 2 years old are suggested.

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Section: Discussionmentioning

confidence: 99%