Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57

Lu, Lianjun; Qiu, Jianhua; Liu, Shunli; Luo, Wenjing

doi:10.1158/1535-7163.mct-07-2222

Cited by 24 publications

(18 citation statements)

References 32 publications

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“…In particular, immunoblot analysis showed that EB1089 inhibited the secretion of IGF-2 and stimulated the production IGFBP-6. More recently Lu et al (2008) reported that EB1089 inhibits the proliferation of Hep-2 human laryngeal squamous carcinoma cells. The growthinhibiting activity of this molecule appeared to be due to an increase of p57 cyclin-dependent kinase inhibitor at mRNA and protein levels induced by this molecule.…”

Section: Eb1089 (Seocalcitol)mentioning

confidence: 99%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

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Section: Eb1089 (Seocalcitol)mentioning

confidence: 99%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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“…It has been reported that a vitamin D3 analog, EB1089, inhibits the proliferation of human laryngeal squamous carcinoma cells by inducing the accumulation of p57 Kip2 . Of interest, the molecule is about 60-fold more potent than vitamin D3 and does not show significant hypercalcemic effects (153). In addition, zoledronic acid, a bisphosphonate molecule endowed with interesting antiproliferative activity, has been reported to increase the level of p57 Kip2 in leukemic cell lines (154).…”

Section: Cdkn1c Targeting and Cancer Treatmentmentioning

confidence: 99%

p57Kip2 and Cancer: Time for a Critical Appraisal

Borriello

Caldarelli

Bencivenga

et al. 2011

Molecular Cancer Research

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p57Kip2 is a cyclin-dependent kinase inhibitor belonging to the Cip/Kip family, which also includes p21Cip1 and p27Kip1. So far, p57Kip2 is the least-studied Cip/Kip protein, and for a long time its relevance has been related mainly to its unique role in embryogenesis. Moreover, genetic and molecular studies on animal models and patients with Beckwith-Wiedemann syndrome have shown that alterations in CDKN1C (the p57Kip2 encoding gene) have functional relevance in the pathogenesis of this disease. Recently, a number of investigations have identified and characterized heretofore unexpected roles for p57Kip2. The protein appears to be critically involved in initial steps of cell and tissue differentiation, and particularly in neuronal development and erythropoiesis. Intriguingly, p27Kip1, the Cip/Kip member that is most homologous to p57Kip2, is primarily involved in the process of cell cycle exit. p57Kip2 also plays a critical role in controlling cytoskeletal organization and cell migration through its interaction with LIMK-1. Furthermore, p57Kip2 appears to modulate genome expression. Finally, accumulating evidence indicates that p57Kip2 protein is frequently downregulated in different types of human epithelial and nonepithelial cancers as a consequence of genetic and epigenetic events. In summary, the emerging picture is that several aspects of p57Kip2's functions are only poorly clarified. This review represents an appraisal of the data available on the p57Kip2 gene and protein structure, and its role in human physiology and pathology. We particularly focus our attention on p57Kip2 changes in cancers and pharmacological approaches for modulating p57Kip2 levels. Mol Cancer Res; 9(10); 1269–84. ©2011 AACR.

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“…Vitamin D analogs inhibit proliferation of human laryngeal squamous carcinoma cells 18 . Lipworth et al 19 observed a negative correlation between dietary intake of vitamin D and risk of squamous cell carcinoma of the esophagus and oral or pharyngeal cancer.…”

Section: Discussionmentioning

confidence: 99%