Vitamin D3-fortified milk did not affect glycemic control, lipid profile, and anthropometric measures in patients with type 2 diabetes, a triple-blind randomized clinical trial

Salehi, Saedeh; Sadeghi, Fatemeh; Akhlaghi, Masoumeh; Hanifpour, Mohammad Amin; Roshanzamir, Mahdi

doi:10.1038/s41430-017-0062-1

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…In a large-scale study, Al-Daghri et al 56 found that WHR was less significant than other anthropometric measures of obesity regarding the strength of association with VD status. However, the inverse correlation observed between VD levels with waist 49,50,57,58 or hip 51,53,59,60 circumferences in previous studies may result due to subcutaneously visceral adiposity alterations. 39,46,54,61 Similar alterations were also noted in elderly Korean women.…”

Section: Discussionmentioning

confidence: 66%

<p>Correlation of selected stress associated factors with vitamin D deficiency in Jordanian men and women</p>

Abu-Samak

AbuRuz

Masa’Deh

et al. 2019

IJGM

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Background: To identify stress associated factors for vitamin D deficiency (VDD) in healthy Jordanian people based on serum 25(OH)D levels. Design: Prospective cohort study. Methods: Three hundred and seventy-one Jordanian men and women aged 17-52 years, who were identified as VD deficient 25(OH)D <30 ng/mL, were eligible to participate in the study. Serum vitamin 25(OH) D was measured using chemiluminescent immunoassay. Cortisol, parathyroid hormone, calcium, phosphate, fasting lipid profile, and blood glucose were also analyzed. Questionnaires were used to collect lifestyles parameters. Anthropometric parameters including: body mass index (BMI), waist (W) and hip (H) circumferences, W/H ratio (WHR) were also calculated. Results: The vast majority (91%) of the participants had vitamin D deficiency (25-(OH) D <30 ng/mL). Positive correlations were observed between vitamin D deficiency and the following anthropometric parameters in all study sample; gender (P=0.010), height (P=0.22), height/hip ratio (P=0.015) and waist/hip ratio (P=0.013). Lifestyle parameters that indicated very weak positive correlations with VDD were number of family members (P=0.011) and insufficient exposure to sunlight (P=0.023). The following clinical parameters showed weak or very weak correlations with VDD; serum cortisol (r=0.318), low density lipoprotein (r=0.246) and total cholesterol (r=0.133). Skin color and water pipe tobacco smoking were added to the multivariable stepwise regression analyses as they have been weakly correlated with VDD. These predictors together explained only 12.2% of the variance in serum cortisol levels in the VDD study sample. Conclusion: A weak positive association between VDD and elevated serum cortisol was observed in this study. Subcutaneous changes may be involved in that association but further studies are needed to clarify a potential role for adrenocorticotropic hormone (ACTH).

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Section: Discussionmentioning

confidence: 66%

<p>Correlation of selected stress associated factors with vitamin D deficiency in Jordanian men and women</p>

Abu-Samak

AbuRuz

Masa’Deh

et al. 2019

IJGM

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“…Four studies out of five used daily dose of 25 µg/d, heterogeneity was 44% in those studies. (13)(14)(15)18). The overall efficacy effect was 37.1 nmol/L (95% CI, 28.6-45.7), relating to a 1.4 nmol/L increase in 25(OH)D for each 1 µg/d ingested.…”

Section: Resultsmentioning

confidence: 95%

“…1). A total of 5 clinical trials (13)(14)(15)(16)(17) involving 59 to 101 participants ( Table 1). All studies were conducted in adult populations.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were conducted in participants with type 2 diabetes (13-15, 18) and 1 in women only (17). Four studies used dairy products (13,15,(17)(18) as a food source and bread was used in one experiment (14). The daily dose of vitamin D3, 1000 and 2000 IU, and the duration of administration ranged from 8 to 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…The daily dose of vitamin D3, 1000 and 2000 IU, and the duration of administration ranged from 8 to 12 weeks. Three studies used HPLC (high pressure liquid chromatography) to measure serum 25(OH)D (13)(14)18) and two studies used ELISA (enzyme linked immunosorbent assay) (15,17). All studies scored ≥3 on the Jadad scale.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of Food Fortification with Vitamin D in Iranian Adults: A Systematic Review and Meta-Analysis

Nikooyeh

2018

Nutr Food Sci Res

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There are a number of reports showing high prevalence of hypovitaminosis D across Iran. The objective of this study was to evaluate whether food fortification with vitamin D has the potential to increase serum 25(OH)D concentrations in Iranian people. MEDLINE, PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials were searched for randomized controlled clinical trials involvingIranian participants to assess the effect of fortified food either with vitamin D2 or D3 (with or without calcium) versus control on serum 25(OH)D concentrations. Four studies used dairy products as a food source and bread was used in one experiment. The daily dose of vitamin D3, 1000 and 2000 IU, and the duration of administration ranged from 8 to 12 weeks. The moderate heterogeneity was detected across the included studies (P<0.00001; I 2 =55%).Using a random effects analysis (n=193), the efficacy effect was 34.6nmol/L (95% CI: 28.6, 40.8). The present meta-analysis showed that food fortification with vitamin D could be an effective tool to prevent and control hypovitaminosis D and Iranian population will most probably benefit from the vitamin D fortification as a national policy.

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A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices

et al. 2020

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Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta‐analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 and that compared the effect of Vitamin D‐fortified food versus regular diet in relation to glycemic control. Of the 4,379 studies originally found, 11 articles remained to be assessed for meta‐analysis. Vitamin D fortification was associated with a significant improvement in fasting serum glucose (mean difference [MD]: −2.772; 95% confidence interval [CI]: −5.435 to −0.109) and fasting serum insulin (MD: −2.937; 95% CI: −4.695 to −1.178) in patients with Type 2 diabetes mellitus. A diet with food enriched with Vitamin D was associated with a significant improvement in homeostatic model assessment of insulin resistance (MD: −1.608; 95% CI: −3.138 to −0.079) but was not associated with a significant reduction in hemoglobin A1C (MD: 0.034; 95% CI: −0.655 to 0.069). This meta‐analysis indicates that Vitamin D fortification improves indices of glycemic control. Hence, food fortified with Vitamin D may be of potential therapeutic value in diabetic patients, as an adjuvant therapy.

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Vitamin D3-fortified milk did not affect glycemic control, lipid profile, and anthropometric measures in patients with type 2 diabetes, a triple-blind randomized clinical trial

Abstract: Overall, daily consumption of one cup of milk containing 1000 IU vitamin D for 9 weeks substantially improved vitamin D deficiency in patients with type 2 diabetes but it did not affect cardiometabolic parameters over that of plain milk.

Cited by 12 publications

References 56 publications

<p>Correlation of selected stress associated factors with vitamin D deficiency in Jordanian men and women</p>

<p>Correlation of selected stress associated factors with vitamin D deficiency in Jordanian men and women</p>

Efficacy of Food Fortification with Vitamin D in Iranian Adults: A Systematic Review and Meta-Analysis

A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices

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