Vitamin D3 Is More Potent Than Vitamin D2 in Humans

Heaney, Robert P.; Recker, Robert R.; Grote, James; Horst, Ronald L.; Armas, Laura A.G.

doi:10.1210/endo.152.2.zee741a

Cited by 12 publications

(15 citation statements)

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“…There is no general consensus as to whether the mushroom source D 2 is equally as effective as the animal source D 3 . Indeed, some studies have demonstrated that vitamin D 3 is more efficient than vitamin D 2 [21], while other studies have shown that vitamin D 2 and vitamin D 3 treatment yield equivalent outcomes in the treatment of hypovitaminosis D among young children [22]. What can be stated is that plant sources of vitamin D 2 are more sustainable than D 3 sources of animal origin [23].…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D2 Fortification Using Pleurotus ostreatus in a Whole-Grain Cereal Product on Child Acceptability

et al. 2019

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Vitamin D2 deficiency is one of the most common micronutrient insufficiencies among children. Few foods, mainly those derived from animal sources, naturally contain this vitamin. The basidiomycete mushroom Pleurotus ostreatus could be used as an innovative and sustainable ingredient for food fortification with vitamin D2. This study was aimed at exploring children’s acceptance of a whole-cereal-based product (breadsticks) combined with increasing concentrations of P. ostreatus powder rich in vitamin D2. The food neophobia trait (fear of trying unfamiliar and new food) on sample acceptability was also investigated. One hundred and three children (47 girls and 56 boys, aged 9–11 years) were recruited, and breadstick-liking was studied in relation to gender and neophobic traits. Results showed that the samples enriched in vitamin D2 were well accepted by children even if liking decreased with increasing concentration of mushroom powder. Generally, neophilic subjects gave higher liking scores compared with the neophobic ones, especially for the modified samples. New, well-accepted fortified products could be developed using an adequate concentration of mushroom powder to deal with the increasing vitamin D2 deficiency among children.

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Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D2 Fortification Using Pleurotus ostreatus in a Whole-Grain Cereal Product on Child Acceptability

et al. 2019

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“…Recently, there is increasing evidence to support the combination use of calcium (500 mg daily) with vitamin D. 41 Vitamin D3 is preferable to vitamin D2 as a supplement because of its longer half life and stronger potency, leading to 2e3 times greater storage after administration. 57 Serum calcium, phosphorus, ALP, 25(OH)D, PTH levels, and urine calcium to creatinine ratios with radiography should be monitored after treatment. 7 Adult vitamin D repletion depends on baseline serum 25(OH)D concentration and effective absorptive capacity.…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

Vitamin D and health - The missing vitamin in humans

Chang

Lee

2019

Pediatrics & Neonatology

273

197

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Severe vitamin D deficiency may cause rickets in infants or children and osteomalacia in adults, though it is now uncommon in developed countries. However, subclinical vitamin D deficiency is more prevalent, and it is associated with osteoporosis and higher incidence of falls or fractures. It was reported that 96% children with rickets were breastfed, since breast milk contains inadequate vitamin D. The American Academy of Pediatrics 2008 recommended infants who were exclusively or partially breastfed required 400 international units vitamin D daily from the first few days of life. Furthermore, since vitamin D receptors are present all over the body, insufficient vitamin D status may correlate with several extra-skeletal effects, such as pregnancy-related complications and immune dysfunction. This paper discusses the researches regarding system-based vitamin D effects, the possible risk factors leading to vitamin D deficiency, and the recommendations of vitamin D requirements. It is well-known that vitamin D can be obtained by sun exposure or limited natural dietary sources. The American Academy of Dermatology declared ultraviolet radiation to be a known skin carcinogen, so it may not be safe or efficient to obtain vitamin D via sun exposure or other artificial sources. Therefore, many pediatricians and physicians recommend appropriate vitamin D supplementation to achieve optimal plasma concentration. Trials assessing the effects of vitamin D repletion and establishing its optimum serum level are ongoing. Medical advice for vitamin D supplementation should be individualized accordingly.

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“…En el caso de los efectos de la vitamina D 2 , que representa la forma más comúnmente ingerida, pocos han sido los estudios que evalúen sus efectos en modelos experimentales, basados en ensayos clínicos (16,17) que han sugerido que su potencia y duración de acción serían menores que las obtenidas con el uso de vitamina D 3. A pesar de ello, el presente estudio demuestra que los efectos en los niveles de glicemia son similares, no habiendo diferencias significativas entre ninguna dosis de los grupos de estudio que usaron vitamina D 2 y vitamina D 3 .…”

Section: Discussionunclassified

Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas

Jokada¹,

Arroyo-Acevedo²,

Chávez-Rimache³

et al. 2017

Rev. per. med. integr.

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Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas. Rev Peru Med Integrativa.2017;2(3):798-802. Historia del artículo Información del artículo ResumenObjetivo. Determinar el efecto del Ergocalciferol (vitamina D 2 ) y el colecalciferol (vitamina D 3 ) sobre el control de la glicemia en ratas. Materiales y métodos. Estudio experimental. Se utilizó 48 ratas machos Wistar de 12 semanas de edad, con un peso de 200 ± 50 g, distribuidas de manera aleatoria en ocho grupos de seis: control negativo (suero fisiológico a 2 mL/dieta balanceada); control positivo (suero fisiológico a 2 mL/dieta modificada); EXP 1 (vitamina D 2 a 10000 UI/kg /dieta modificada); EXP 2 (vitamina D 2 a 35000 UI/kg /dieta modificada); EXP 3 (vitamina D 2 a 70000 UI/kg /dieta modificada); EXP 4 (vitamina D 3 a 10000 UI/kg /dieta modificada); EXP 5 (vitamina D 3 a 35000 UI/kg /dieta modificada), y EXP 6 (vitamina D 3 a 70000 UI/kg /dieta modificada); se administraron dos tipos de dietas (dieta balanceada y dieta modificada a base de colesterol y fructuosa) y vitaminas D 2 y D 3 de manera conjunta durante las 13 semanas de estudio. Resultados. El promedio de glicemia del grupo control negativo (CN) fue 80,17 mg/dL; en los grupos experimentales fueron: 91,17 mg/dL (EXP1); 90,17 mg/dL (EXP2); 87,67 mg/dL (EXP3); 91,67 mg/dL (EXP4); 88,33 mg/dL (EXP5); 81,83 mg/dL (EXP6), y en el grupo control positivo (CP) fue 134,84 mg/dL. Conclusión. Los grupos con dieta modificada y que recibieron ergocalciferol (vitamina D 2 ) o colecalciferol (vitamina D 3 ) mostraron niveles menores de glicemia en comparación con los que no recibieron suplementación, no habiendo diferencias significativas entre la utilización de algún tipo de vitamina D o las dosis de 35000 y 70000 UI. Palabras clave: Ergocalciferoles; Hiperglicemia; Experimentación Animal (Fuente: DeCS). Effect of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) on glycemic control in rats AbstractObjective. Determine the effect of Ergocalciferol (Vitamin D 2 ) and Cholecalciferol (Vitamin D 3 ) on glycemic control in rats. Materials and Methods. Experimental study. 48 male Wistar rats aged 12 weeks of age were used, which weighted 200 ± 50 g, distributed randomly into eight groups of 6 members each one: negative control (saline solution at 2 mL/ balanced diet), positive control (saline solution at 2 mL/modified diet), EXP 1 (Vitamin D 2 at 10000 IU/kg / modified diet), EXP 2 (vitamin D 2 at 35000 IU/kg / modified diet), EXP 3 (Vitamin D 2 at 70000 IU/kg / modified diet), EXP 4 (Vitamin D 3 at 10000 IU/kg / modified diet), EXP 5 (Vitamin D 3 at 35000 IU/kg / modified diet), EXP 6 (Vitamin D 3 at 70000 IU/kg / modified diet); two types of diets (balanced diet and modified diet based on cholesterol and fructose) and vitamins D 2 and D 3 were administered together during the 13 weeks of study. Results. The average of glycemia in the negative control group (NC) was 80.17 mg/dL; in the experimental groups were: 91.17 mg/dL (EXP1), 90.17 mg...

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Vitamin D3 Is More Potent Than Vitamin D2 in Humans

Abstract: This article appears in The Journal of Clinical Endocrinology & Metabolism, published December 22, 2010, 10.1210/jc.2010-2230

Cited by 12 publications

References 0 publications

Effect of Vitamin D2 Fortification Using Pleurotus ostreatus in a Whole-Grain Cereal Product on Child Acceptability

Effect of Vitamin D2 Fortification Using Pleurotus ostreatus in a Whole-Grain Cereal Product on Child Acceptability

Vitamin D and health - The missing vitamin in humans

Efecto del ergocalciferol (vitamina D2) y el colecalciferol (vitamina D3) sobre el control de la glicemia en ratas

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