Vitamin D3 Role in Women Undergoing Intracytoplasmic Sperm Injection for Successful Pregnancy

Abstract

Objective: vitamin D role is investigated in this work to establish the effect of its level on the outcome of patients undergoing Intracytoplasmic sperm injection (ICSI) for fertility treatment. Aim: To study the role of vitamin D on the success of women conceiving under Intracytoplasmic sperm injection Method: In High Institute of Infertility Diagnosis and Assisted Reproductive Techniques, Al-Nahrain University, Iraq, has conducted a study from September 2017 to April 2018. A total of 100 infertile women underwent controlled ovarian hyperstimulation for the intracytoplasmic sperm injection cycle. Antagonist ovulation induction protocol was used. Serum vitamin D3 level, oocyte maturation, and embryo quality were performed. The relationship between serum vitamin D3, quality of oocytes and embryos, fertilization rate, and pregnancy rate were determined Results: This study showed that mean serum vitamin D was significantly higher in women who succeeded to get pregnant in comparison to those who unfortunately failed to get pregnant. The variation is 18.10 ±3.51 versus 14.44 ±2.87 ng/ml, respectively. The level of significance was (P = 0.004). There was no significant correlation between serum vitamin D and the quality of oocytes and embryos, fertilization rate Conclusions: This study demonstrated a significant difference in mean serum vitamin D concentration between the group of women with successful pregnancy and the group of women who failed to achieve pregnancy. In addition, with exception of the significant negative correlation with LH. Serum vitamin D can be considered a predictive marker for successful ICSI.