Vitamin E

EVANS, HERBERT McLEAN

doi:10.1001/jama.1932.27410580003009

Cited by 28 publications

(4 citation statements)

References 2 publications

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“…Initially known as “antisterility factor X”, the importance of vitamin E was first recognized in 1922 when Herbert Evans and Katherine Bishop noticed that leafy greens and small amounts of wheat germ oil corrected infertility in rats [ 26 ]. They pinpointed a new vitamin as the causative agent, with wheat germ oil being its highest source [ 26 ]. This vitamin, given the official name of vitamin E, is a mixture of 8 lipophilic isomers—4 saturated tocopherols and 4 unsaturated tocotrienols.…”

Section: Introductionmentioning

confidence: 99%

Tocotrienols as an Anti-Breast Cancer Agent

et al. 2021

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In the past few years, breast cancer has become the most prevalent type of cancer. The majority of patients receive combinatorial chemotherapy treatments, which may result in increased risk of developing drug resistance, a reduced quality of life, and substantial side effects. Treatment modalities that could lessen the physical toll of standard treatments or act in synergy with chemotherapeutic treatments would benefit women worldwide. Research into tocotrienols has thus far demonstrated their potential to be such an agent, with tocotrienols surpassing the pharmacological potential of tocopherols. Further research using in vitro and preclinical breast cancer models to support clinical trials is needed. This review uses bibliometric analysis to highlight this gap in research and summarizes the current and future landscape of tocotrienols as an anti-breast cancer agent.

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Section: Introductionmentioning

confidence: 99%

Tocotrienols as an Anti-Breast Cancer Agent

et al. 2021

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“…Their evidence was slender, it is true, but it clearly pointed the way for further study. Attention was diverted for a time from this path because H. M. Evans could not reconcile the apparent maintenance of ovarian structure and function in the female rat and the steadv degeneration of the testicle in the male with anterior pituitary failure [5].…”

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Discussion on Vitamin E

1939

Proceedings of the Royal Society of Medicine

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“…thick film, showed that the factor is not destroyed to any great extent under these circumstances. According to Evans [1932] vitamin E will resist such treatment. On partition between light petroleum and 90 % methyl alcohol the vitamin behaves, as mentioned, like vitamin E. It appears that a loss occurs during the saponification.…”

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confidence: 99%

The antihaemorrhagic vitamin of the chick

Dam

1935

Biochemical Journal

281

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] deal with a deficiency disease resembling scurvy in chicks which cannot be prevented by ascorbic acid and the cause of which is ascribed to the lack of a particular antihaemorrhagic factor (or factors) in the diet. Sch6nheyder [1935] has shown that there is an enormous retardation of the clotting of the blood of chicks suffering from this haemorrhagic diathesis. The nature and distribution of the antihaemorrhagic factor have now been investigated. The investigation has led to the discovery of the fact that the factor is a fat-soluble vitamin occurring in hog-liver, hemp seed, certain cereals and vegetables, and must be different from vitamins A, D and E. It is proposed to term this factor vitamin K (Koagulations-Vitamin in German and the Scandinavian languages). The following groups of foods have been tested: (1) cereals and seeds, (2) vegetables, (3) animal organs, (4) different fats and oils, (5) hen's egg. Two of the most active substances, hog-liver and hemp seed, were divided into ether-soluble and ether-insoluble fractions, and, since the active principle was found to be fat-soluble, an elaborate fractionation of hog-liver fat was carried out. The question of the identity of the antihaemorrhagic factor with already known fat-soluble vitamins has been attacked by adding large amounts of vitamins A, D and E to the basal diet. EXPERIMENTAL.

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Vitamin E

Cited by 28 publications

References 2 publications

Tocotrienols as an Anti-Breast Cancer Agent

Tocotrienols as an Anti-Breast Cancer Agent

Discussion on Vitamin E

The antihaemorrhagic vitamin of the chick

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