Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols

Constantinou, Constantina; Charalambous, Christiana; Kanakis, Dimitrios

doi:10.1007/s00394-019-01962-1

Cited by 49 publications

(41 citation statements)

References 121 publications

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“…Some recent studies (published in 2011‐2019) are summarized in Table 4. Earlier work has been covered by some excellent recent reviews 7–9,12 and a book 115 . Some of the proposed molecular targets or pathways are highlighted in Figure 3.…”

Section: Laboratory Studies On Ve and Cancer Preventionmentioning

confidence: 99%

“…In 2010, we reviewed the cancer‐preventive activities of tocopherols and tocotrienols 2 . Since then, this topic has been studied by a large number of investigators and reviewed by different authors 7–12 …”

Section: Introductionmentioning

confidence: 99%

“…2 Since then, this topic has been studied by a large number of investigators and reviewed by different authors. [7][8][9][10][11][12] A literature search on PubMed in June 2019 yielded 1804 articles on "vitamin E and cancer," 539 articles on "tocopherols and cancer," and 156 articles on "tocotrienols and cancer" for the past 10 years. The present article is an updated review of the cancerpreventive activities of different forms of VE in human and laboratory studies.…”

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confidence: 99%

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Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols

Yang

Luo

Zeng

et al. 2020

Molecular Carcinogenesis

127

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α‐Tocopherol (α‐T) is the major form of vitamin E (VE) in animals and has the highest activity in carrying out the essential antioxidant functions of VE. Because of the involvement of oxidative stress in carcinogenesis, the cancer prevention activity of α‐T has been studied extensively. Lower VE intake or nutritional status has been shown to be associated with increased cancer risk, and supplementation of α‐T to populations with VE insufficiency has shown beneficial effects in lowering the cancer risk in some intervention studies. However, several large intervention studies with α‐T conducted in North America have not demonstrated a cancer prevention effect. More recent studies have centered on the γ‐ and δ‐forms of tocopherols and tocotrienols (T3). In comparison with α‐T, these forms have much lower systemic bioavailability but have shown stronger cancer‐preventive activities in many studies in animal models and cell lines. γ‐T3 and δ‐T3 generally have even higher activities than γ‐T and δ‐T. In this article, we review recent results from human and laboratory studies on the cancer‐preventive activities of different forms of tocopherols and tocotrienols, at nutritional and pharmacological levels. We aim to elucidate the possible mechanisms of the preventive actions and discuss the possible application of the available information for human cancer prevention by different VE forms.

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Section: Laboratory Studies On Ve and Cancer Preventionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols

Yang

Luo

Zeng

et al. 2020

Molecular Carcinogenesis

127

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“…[21] Recent studies also have reviewed the benefits of these compounds such as anticancer, anti-inflammatory, and cancer preventive effects. [22,23] Phytol was the major compound isolated from the ethyl acetate extract of P. bleo leaves. The results showed that the ethyl acetate extract exerted the most potent cytotoxic effect against HeLa cells followed by MDA-MB-231 cells.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Cytotoxic Effects of Crude Extracts of Pereskia Bleo Leaves

Mohd-Salleh

Ismail

Wan-Ibrahim

et al. 2020

Journal of Herbs, Spices & Medicinal Plants

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The phytocompounds in crude solvent extracts of Pereskia bleo leaves were identified and their cytotoxic effects on cancer cell lines were determined. Crude extracts were obtained via maceration and subjected to GCMS analysis. Then, each extract was incubated with HeLa, MDA-MB-231, SW480, and NIH/3T3 cell lines for 72 h. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was done to determine IC 50 values of each extract. Terpenoids, sterols, alkaloids, fatty acids and phenolic compounds were identified from the crude extracts of P. bleo leaves. Other compounds identified were γ-sitosterol, β-tocopherol, and γ-tocopherol. The ethyl acetate extract had potent cytotoxic effect against HeLa and MDA-MB-231 cancer cells as noted by the lowest IC 50 values ARTICLE HISTORY

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“…In addition, we present examples of current efforts that aim to modulate key proteins of the redox landscape in cancer, which is summarized in Table 1. [38,39] Complex III Atovaquone AML, NSCLC (approved for malaria) [40] Complex IV ATN-224 various cancers [41,42] Mitochondria, enzymes DHODH Brequinar various cancers [43,44] Leflunomide various cancers (approved for rheumatoid arthritis) [45] Teriflunomide basic research (approved for multiple sclerosis)…”

Section: Introductionmentioning

confidence: 99%

Targeting the Redox Landscape in Cancer Therapy

Narayanan

Özcelik

2020

Cancers

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Reactive oxygen species (ROS) are produced predominantly by the mitochondrial electron transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum. The antioxidative defense counters overproduction of ROS with detoxifying enzymes and molecular scavengers, for instance, superoxide dismutase and glutathione, in order to restore redox homeostasis. Mutations in the redox landscape can induce carcinogenesis, whereas increased ROS production can perpetuate cancer development. Moreover, cancer cells can increase production of antioxidants, leading to resistance against chemo- or radiotherapy. Research has been developing pharmaceuticals to target the redox landscape in cancer. For instance, inhibition of key players in the redox landscape aims to modulate ROS production in order to prevent tumor development or to sensitize cancer cells in radiotherapy. Besides the redox landscape of a single cell, alternative strategies take aim at the multi-cellular level. Extracellular vesicles, such as exosomes, are crucial for the development of the hypoxic tumor microenvironment, and hence are explored as target and as drug delivery systems in cancer therapy. This review summarizes the current pharmaceutical and experimental interventions of the cancer redox landscape.

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Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols

Cited by 49 publications

References 121 publications

Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols

Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols

Phytochemical Screening and Cytotoxic Effects of Crude Extracts of Pereskia Bleo Leaves

Targeting the Redox Landscape in Cancer Therapy

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