Vitamin E and selenium administration synergistically mitigates ivermectin and doramectin-induced testicular dysfunction in male Wistar albino rats

Ahmed, Ahmed Ezzat; Alshehri, Ali; Alkahtani, Mohammed Ali; Elbehairi, Serag Eldin I.; Alshehri, Mohammed; Shati, Ali A.; Alfaifi, Mohammad Y.; Al-Doais, Amin A.; Taha, Ramadan; Morsy, Kareem; El‐Mansi, Ahmed A.

doi:10.1016/j.biopha.2020.109841

Cited by 28 publications

(35 citation statements)

References 71 publications

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“…Depending on (Arise and Malomo 2009), these high levels of renal plasma parameters may be attributed to the impairment of the glomerular filtration that produces the retention of creatinine and urea. Our results were matched with the findings of several studies that determine the effects of therapeutic and/or double therapeutic doses of IVM on the variation of renal biomarkers (Arise and Malomo 2009 ;El Sawy et al, 2015 ;Elzoghby et al, 2015 ;Al-Jassim et al, 2016;Ahmed et al, 2020). In the other hand, our results are in disagreement with those of (Omshi et al, 2018) who determined a nonsignificant change of creatinine level in IVM treated group compared to the control.…”

Section: Discussionsupporting

confidence: 89%

“…However, several toxic effects were reported in sensitive populations or are related to involuntary overdoses. The dose and dosage of IVM for animals and humans are changing depending on the clinical case and the type of parasites (Ahmed et al, 2020). According to (Barrett et al, 2016), parenteral IVM is better tolerated compared to oral administration which is associated with embarrassing gastrointestinal side effects.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Vitamin C on Ivermectin Induced Toxicity on Kidney Functions and Brain Tissue in Rabbits (Oryctolagus cuniculus

Makhlouf

Hassina

Soumya

et al. 2021

Egyptian Academic Journal of Biological Sciences, D. Histology

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The aim of this study was to evaluate the effects of repeated intake of a high dose of Ivermectin (IVM) alone or with coadministration of Vitamin C on kidney biochemical parameters and histological structure of kidney and brain of male rabbits (Oryctolagus cuniculus). Male rabbits were distributed into four groups (5 rabbits/group) and treated for three consecutive weeks: receiving distilled water; IVM 2 mg/kg b.w. subcutaneously, 3 times a week; IVM + Vitamin C 20 mg/1mL by gavage and IVM + Vitamin C 200mg /kg of diet in food. IVM significantly (p < 0.05) increased the plasma level of creatinine compared to the control group. Cotreatment with vitamin C orally by gavage ameliorated this level compared to IVM group. The histopathological examination of kidney sections in IVM alone treated group showed dilated Bowmans' spaces, dilated renal tubules, vascular congestion and cell infiltration. The brain tissues demonstrated vacuolated neuropil and degenerative changes in nerve cells in both the cerebral cortex and hippocampus of IVM-treated rabbits. However, these histological changes were moderate in both vitamin C co-treated groups. In conclusion, vitamin C has a protective effect against nephrotoxicity and neurotoxicity induced by subacute administration of a high dose of IVM.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Protective Effects of Vitamin C on Ivermectin Induced Toxicity on Kidney Functions and Brain Tissue in Rabbits (Oryctolagus cuniculus

Makhlouf

Hassina

Soumya

et al. 2021

Egyptian Academic Journal of Biological Sciences, D. Histology

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“…Antioxidant therapy improves sperm parameters 48 and testicular tissue 22 against cytotoxic damage and can be effective in reducing BPA toxicity. 16,46,49 According to the studies, the protective effect of VE against the toxicity of formaldehyde, 50 sodium valproate, 51 chromium, 49 and sodium aside 46 on the testis action of adult rats is undeniable. VE by increased the activity of antioxidant enzymes and reduced lipid peroxidation 52 compensate for the adverse changes caused by BPA on the testicular tissue, sperm parameters, testosterone and MDA levels.…”

Section: Discussionmentioning

confidence: 99%

“…VE by increased the activity of antioxidant enzymes and reduced lipid peroxidation 52 compensate for the adverse changes caused by BPA on the testicular tissue, sperm parameters, testosterone and MDA levels. 16,52 On the other side, VE can reduce LPO and increase serum testosterone levels in rats. 13 The main function of VE is inhibiting the phospholipid membrane peroxidation and protect cell membranes through its antioxidant action.…”

Section: Discussionmentioning

confidence: 99%

“…53 Besides, VE is a non-enzymatic defense system in testicular mitochondria. 16 This vitamin can inhibit oxidative damage in the testis 16,49 and prevents the apoptosis induction in spermatogenic, Sertoli, and Leydig cells 18 which, it plays an important role in their count, as well as, sperm viability. 22,49 Additionally, VE can return glutathione to its normal levels on the system intracellular free radical scavenging and reduces the oxidative stress levels.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A

Malmir

Mehranjani

Faraji

et al. 2021

Toxicology Research and Application

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Among researchers, environmental pollutants and their contribution to male fertility are still being discussed. The use of antioxidants manages to boost the reproductive system with the scavenging of free radicals. This study aimed to investigate the inhibiting function of Vitamin E (VE) on Bisphenol-A (BPA) toxicity in the male rats’ reproductive system. Male rats were divided into 4 groups: control (negative control) group, BPA group treated by 250 mg/kg/day (positive control), VE group treated by 150 mg/kg/day (comparative control) and BPA + VE group that received both doses at the same time (Oral treatment by gavage; 56 days). Sperm parameters, testicular tissue morphometric and biochemical tests were evaluated. Sperm count, motility, viability, normal morphology, sperm tail length, spermatogenesis index and serum testosterone levels significantly decreased in the BPA group compared to the control group. Versus a significant enhancement in the positive-TUNEL germinal cells and serum malondialdehyde (MDA) levels were observed. Moreover, BPA exhibited no effect on sperm maturity and DNA integrity. In the simultaneous treatment group (BPA + EV), VE could improve and regulate all the mentioned parameters within the control group range. As mentioned, there was a significant difference in the results in the positive control group compared to the negative control group. But these data improved significantly in the BPA + VE. It can be concluded that in this group, VE was able to overcome the toxicity caused by positive control in their simultaneous treatment and maintain the data at the negative control group range. Therefore, no significant change was observed in the BPA + VE group compared to the negative control group.

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Synergistic effects of EP‐1 and ivermectin mixture (iEP‐1) to control rodents and their ectoparasites

Liu

Ren

Wan

et al. 2022

Pest Management Science

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BACKGROUND: Ectoparasites of rodents play significant roles in disease transmission to humans. Conventional poisoning potentially reduces the population densities of rodents, however, they may increase the ectoparasite loads on the surviving hosts. EP-1 has been shown to have anti-fertility effects on many rodent species, while ivermectin is effective in controlling ectoparasites. In this study, we examined the combined effects of EP-1 and ivermectin mixture (iEP-1) baits on rodents and their corresponding flea/tick loads. RESULTS: In males, the weight of testis, epididymis, and seminiferous vesicle were reduced to less than 33%, 25%, and 17%, respectively, compared to the control group following administration of iEP-1 for 7 days. The weight of the uterus increased by approximately 75%. After 5 days of iEP-1 intake, all ticks were killed, whereas 94% of fleas on mice died after 3 days of bait intake. In the field test near Beijing, the flea index was reduced by more than 90% after 7 days of iEP-1 bait delivery. In a field test in Inner Mongolia, the weights of testis, epididymis, and seminiferous vesicle were significantly reduced by 27%, 32%, and 57%, respectively, 2 weeks after iEP-1 bait delivery. Approximately 36% rodents exhibited obvious uterine oedema accompanied by a weight increase of about 150%. The flea index was reduced by over 90%. CONCLUSION: Our results indicated that iEP-1 is a promising treatment for reducing the abundance of both small rodents and their ectoparasites; this will be effective for managing rodent damage and transmission of rodent-borne diseases associated with fleas and ticks.

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Vitamin E and selenium administration synergistically mitigates ivermectin and doramectin-induced testicular dysfunction in male Wistar albino rats

Cited by 28 publications

References 71 publications

Protective Effects of Vitamin C on Ivermectin Induced Toxicity on Kidney Functions and Brain Tissue in Rabbits (Oryctolagus cuniculus

Protective Effects of Vitamin C on Ivermectin Induced Toxicity on Kidney Functions and Brain Tissue in Rabbits (Oryctolagus cuniculus

Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A

Synergistic effects of EP‐1 and ivermectin mixture (iEP‐1) to control rodents and their ectoparasites

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