Vitamin E and Selenium in Gentamicin Nephrotoxicity

Abstract

<jats:p> 1 The sequence of renal cellular membrane damage induced by gentamicin was studied in the rat by using the release of alkaline phosphatase, acid phosphatase, muramidase and protein from renal cells as indices of renal damage. </jats:p><jats:p> 2 The protective effect of a combination of vitamin E and selenium against renal damage was also investigated. </jats:p><jats:p> 3 Gentamicin (60 mg kg<jats:sup> -1</jats:sup> body weight) was nephrotoxic within 12 h of the first dose. </jats:p><jats:p> 4 The plasma membrane of the renal tubules is damaged before the lysosomal membrane is affected. </jats:p><jats:p> 5 A combination of vitamin E (1 mg g<jats:sup>-1</jats:sup> body weight) and selenium (4 × 10-3 mg g<jats:sup>-1</jats:sup> body weight) attenuates the renal damage induced by gentamicin. Results suggest synergism between vitamin E and selenium in attenuating the renal damage. The possible mechanism of attenuation is discussed. </jats:p><jats:p> 6 Vitamin E and selenium may have anti-diuretic potential. </jats:p>

Effect of Vitamin E and Pentoxifylline on Glycerol-Induced Acute Renal Failure

“…Due to its antioxidant activity, vitamin E may have beneficial effects on the prevention and treatment of acute renal failure. The data about the role of vitamin E on the prevention and treatment of acute renal failure are limited and contradictory (table 2) [10, 11, 12, 13, 14, 15, 16, 17]. To our knowledge, the effect of vitamin E has not been studied previously in a glycerol-induced acute renal failure model, and our study did not show any beneficial effect of vitamin E under these conditions.…”

Gentamicin-Induced Nephrotoxicity in Rats Ameliorated and Healing Effects of Resveratrol

“…[30][31][32] Furthermore, results of many studies have shown that the altered concentrations of various biochemical indicators of oxidative stress in kidney tissue are due to GEN. [33][34][35] Because of the obvious responsibility of ROS in GEN induced renal damage, several antioxidant agents have been used to block GEN nephrotoxicity. [36][37][38] In this study, we used a polyphenolic compound RSV, which was able to increase antioxidant capacity. 39) Aminoglycoside nephrotoxicity in experimental animals and in man was reported to cause reduction in serum potassium levels.…”

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

“…Gentamicin nephrotoxicity is characterized by tubular damage associated with tubular epithelial cell toxicity (1). It has been demonstrated in certain experimental animal studies that free oxygen radicals play a role in nephrotoxicity, and that the use of antioxidants such as vitamin E and selenium decreases nephrotoxicity (2,3).…”