Vitamin E and Selenium Levels of Premature Infants with Severe Respiratory DistressSyndrome and Bronchopulmonary Dysplasia

Falciglia, Horacio S.; Ginn‐Pease, Margaret E.; Falciglia, Grace; Lubin, A Harold; Frank, Donald J.; Chang, William

doi:10.1300/j290v02n01_05

Cited by 11 publications

(13 citation statements)

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“…In a previous study, we reported that premature infants with severe RDS who developed BPD had significantly lower plasma vitamin E levels at the third day of life than those who recovered from RDS and did not develop BPD. 9 The study also found lower selenium levels in both groups during the first month of life. 9 In an effort to elucidate the role of antioxidants in the development of BPD, the present study was designed to investigate other logranular "ground glass" pattern on the initial chest X-ray.…”

Section: Subjectsmentioning

confidence: 56%

“…9 The study also found lower selenium levels in both groups during the first month of life. 9 In an effort to elucidate the role of antioxidants in the development of BPD, the present study was designed to investigate other logranular "ground glass" pattern on the initial chest X-ray. The diagnosis of RDS was supported by an amniotic fluid lecithin/sphymgomyelin ratio of < 2 or a negative gastric aspirate "shake test" (when amniocentesis testing was not available), which indicated lung immaturity.…”

Section: Subjectsmentioning

confidence: 56%

“…We are reporting a 28% BPD rate in a population of premature infants with severe RDS and under 1500 g. In our 1988 RDS and BPD study, we reported a 20% BPD rate. 9 In 1999 and 2000 our BPD rate was 34% and 24%, respectively, in infants under 1500 g (Vermont Oxford Data Base 1999-2000). BPD is a multifactorial disease and its pathophysiology is difficult to study.…”

Section: Discussionmentioning

confidence: 93%

“…Reported plasma selenium levels in premature infants in the United States are usually higher than 80 µg/L. 9 We are reporting that cord plasma selenium was lower (p < 0.004) in RDS and BPD infants compared with healthy premature controls and lower than fullterm infants (p < 0.001). However, third-day-of-life plasma selenium was similar among all three groups, but consistently below the defined deficiency level of 60 µg/L.…”

Section: Discussionmentioning

confidence: 93%

“…31 Previously, we reported plasma alpha-tocopherol levels are lower at 3 days of life in infants who develop BPD. 9 Our speculation was that low tissue vitamin E levels and fast consumption during oxygen therapy was responsible for their low plasma levels. Because urinary malondialdehyde, which measures lipid peroxidation, was not statistically different among groups we speculate that low levels of vitamin E prevents lipid peroxidation.…”

Section: Discussionmentioning

confidence: 97%

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Role of Antioxidant Nutrients and Lipid Peroxidation in Premature Infants with Respiratory Distress Syndrome and Bronchopulmonary Dysplasia

Falciglia¹,

Johnson²,

Sullivan³

et al. 2003

Am J Perinatol

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The objective of this study was to determine if newborn premature infants with severe respiratory distress syndrome (RDS) who developed bronchopulmonary dysplasia (BPD) demonstrate, within the first 3 days of life, lower blood levels of antioxidants and higher urine levels of lipid peroxidation products than premature infants who recovered from RDS. Perinatal variables (gestational age, birth weight, and Apgar scores) and antioxidant indices in cord and in third day of life plasma and red blood cell (RBC) samples from healthy premature infants (n = 35), infants with RDS (n = 23) and infants with BPD (n = 23) were examined. Antioxidant indices included selenium, alpha-tocopherol, total and oxidized glutathione, glutathione peroxidase, superoxide dismutase, and urinary malondialdehyde. By inferential statistics, only the perinatal variables and cord plasma selenium distinguished healthy premature infants from premature infants with RDS or BPD. From perinatal variables and antioxidant indices we calculated: (1) cord to third-day-of-life variable differences, (2) variable-to-variable ratios, and (3) ratios of a difference for one variable to a difference for any second variable. Subset regression analysis yielded an equation (adjusted R2 = 0.8839) that correctly predicted infants who developed BPD 100% of the time. Predictor variables for BPD were gestational age, Apgar at 1 min, cord and third-day-of-life RBC selenium, cord total glutathione, cord and third-day-of-life glutathione peroxidase and nine different ratios involving Apgar scores, RBC selenium, total and oxidized glutathione, alpha-tocopherol, glutathione peroxidase, and superoxide dismutase. In this study, there was no relationship between lipid peroxidation and BPD. There was a higher rate of patent ductus arteriosus, congestive heart failure, and retinopathy of prematurity in infants with BPD. This study confirms that low plasma selenium and alpha-tocopherol levels in premature infants (< or = 30 weeks' gestational age or lower) were significantly associated with an increased respiratory morbidity.

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Section: Subjectsmentioning

confidence: 56%

Section: Subjectsmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

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