Vitamin E at Physiological Levels Enhances Mouse Macrophages to Bind and Incorporate Oxidized Low Density Lipoprotein.

Effect of oxidative stress induced by vitamin E-deficiency and/or nitrogen dioxide (NO 2 ) inhalation on Type IV and Type I allergy responses of mice was investigated. Mice were fed a vitamin E-adequate diet (control: C group) or a vitamin E-deficient diet (-E group). The vitamin E content in the blood of C and -E groups was 1.58 and 0.3 µg/ ml, respectively. Mice of the C and -E groups were exposed to air or air containing NO 2 (5-6 ppm) (C + NO 2 and -E + NO 2 groups) by feeding them the corresponding diets for 1-2 week. In the sensitization with 2,4-dinitrochlorobenzene (DNCB), the degree of lymph node cell proliferation of mice of the C + NO 2 group, as assessed by lymph node assay, was similar to that of mice of the C group. While the degree of cell proliferation of mice of the -E group was lower than that of mice of the C group, the degree of cell proliferation of mice of the -E + NO 2 group was higher than that of mice of the C and C + NO 2 groups. While the DNCB-sensitized IgE levels of mice of the C + NO 2 group were similar to those of mice of the C group, the IgE levels of mice of the -E and -E + NO 2 groups were higher than those of the C and C + NO 2 groups. While the trimellitic anhydride (TMA)-sensitized IgE levels of mice of the -E group were similar to those of mice of the C group, the IgE levels of mice of the C + NO 2 and -E + NO 2 groups were much higher. These results suggest that allergen-sensitized type IV and I allergy responses of mice are enhanced by oxidative stress induced by vitamin E-deficiency and/or NO 2 inhalation.

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Effects of Vitamin E-Deficiency and/or Nitrogen Dioxide Inhalation on Allergen-Sensitized Type IV and Type I Allergy Responses of Mice.

Hiramoto

Kujirai

et al. 2002

JOURNAL OF HEALTH SCIENCE

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Vitamin E at Physiological Levels Enhances Mouse Macrophages to Bind and Incorporate Oxidized Low Density Lipoprotein.

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Effects of Vitamin E-Deficiency and/or Nitrogen Dioxide Inhalation on Allergen-Sensitized Type IV and Type I Allergy Responses of Mice.

Effects of Vitamin E-Deficiency and/or Nitrogen Dioxide Inhalation on Allergen-Sensitized Type IV and Type I Allergy Responses of Mice.

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