Vitamin E-coated cellulose acetate dialysis membrane: long-term effect on inflammation and oxidative stress

Takouli, Lambrini; Hadjiyannakos, Dimitrios; Metaxaki, Polixeni; Sideris, Vasilis; Filiopoulos, Vasilis; Anogiati, Angeliki; Vlassopoulos, Dimosthenis

doi:10.3109/08860221003615795

Cited by 34 publications

(41 citation statements)

References 39 publications

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“…Variation in plasma oxidized low density lipoprotein (Ox-LDL), nitric oxide (NOx) and thiobarbituric acid reactive substances (TBARS) were given in 11 [18,19,24,25,46,48,51,56,65,67,70] , 4 [16,22,57,62] and 8 studies [20,26,29,33,39,44,47,70] , respectively. Thirteen studies [10,20,23,26,30,33,44,48,49,51,58,64,70] reported information on total anti-oxidant status (TAS) and anti-oxidant capacity (AOC).…”

Section: Outcome Datamentioning

confidence: 99%

“…Five studies [32,42,51,55,69] reported information on total serum iron, 11 [17,23,27,32,34,42,51,54,55,64,69] on ferritin levels and 6 [23,32,34,42,54,55] on transferrin saturation (TSAT). Erythropoietin (EPO) dosage was specified in 16 studies [11,16,19,21,23,27,45,50,51,54,55,60,61,64,65,69] .…”

Section: Outcome Datamentioning

confidence: 99%

“…Fifteen studies [11,15,19,21,23,30,32,34,35,61,64,65,[68][69][70] investigated the effect of ViE-m on inflammation. Inflammation was evaluated by changes in C-reactive protein (CRP) and interleukin-6 (IL-6) in 14 [11, 19, [18,20,59,64,70] respectively.…”

Section: Outcome Datamentioning

confidence: 99%

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Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

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Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.

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Section: Outcome Datamentioning

confidence: 99%

Section: Outcome Datamentioning

confidence: 99%

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Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

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“…In 2010, a small (n = 9) observational A-B study on vitamin E-coated cellulose acetate membranes compared with PF membranes [93] reported an improved and long-term control of inflammatory (high-sensitivity CRP, total antioxidant capacity, and IL-6) and oxidative stress (d-ROM test and superoxide dismutase) biomarkers.…”

Section: Vitamin E-bonded Dialyzersmentioning

confidence: 99%

Vitamin E as a Functional and Biocompatibility Modifier of Synthetic Hemodialyzer Membranes: An Overview of the Literature on Vitamin E-Modified Hemodialyzer Membranes

et al. 2012

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Along with one century of history, research has provided many solutions for hemodialysis (HD) biomaterials, encompassing several generations of copolymers that have found wide application in the development of hollow-fiber dialyzer membranes. Polysulfone-based biomaterials have gained increasing consideration and are now the gold standard in the production of biocompatible hemodialyzers. However, even the highest biocompatibility now available cannot exclude that dialyzer membranes and the overall extracorporeal circulation may produce at the subclinical level immunoinflammatory reactions and thus an increased cardiovascular risk of patients on regular HD therapy. The lipophilic antioxidant and radical scavenger vitamin E has been used (as α-tocopherol) to modify cellulosic and synthetic hollow-fiber membranes with the ultimate goal to neutralize harmful reactive species and to mimic lipid structures of blood cell plasmalemma and lipoprotein particles. Besides filtration and biocompatibility, this modifier has introduced a third function of dialyzer membranes, namely ‘antioxidant bioactivity’. Vitamin E can also serve as a template molecule to produce synthetic redox-active and -silent (non-antioxidant) modifiers for future generations of dialyzer membranes. This mini-review article describes the evolution of vitamin E-derived copolymers as a generation of biomaterials that has offered a clinical challenge and still represents a chance to further improving the quality of HD therapy.

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“…Earlier studies have shown that both the use of vitamin E-coated membrane (VEM) dialyzers 2 and 3-hydroxy-3-methyl-glutaryl-CoA (HMGCoA)-reductase inhibitors, or statins, [3][4][5] can have anti-inflammatory and anti-oxidative effects in HD patients. [6][7][8] The primary objective of the present prospective, randomized, crossover study was to compare the effects of both treatments on sensitive markers of inflammation, oxidative stress, and endothelial cell apoptosis in patients on HD, aiming at distinguishing the different treatment effects and their time sequence on these pathogenetic routes.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

et al. 2012

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Background: We investigated the effects of the use of vitamin E-coated membrane (VEM) dialyzer in comparison to simvastatin on markers of chronic inflammation, oxidative stress, and endothelial cell apoptosis in ten patients on chronic hemodialysis (HD), aiming at distinguishing the different treatment effects and their time sequence on these pathogenetic routes. Methods: Ten HD patients were sequentially submitted to a 6-month treatment with the use of VEM and 10 mg of simvastatin daily, interrupted by a 3-month washout period. At baseline, at 3, and 6 months of each trial, serum C-reactive protein (CRP), apolipoprotein (Apo) A1 and B, lipoprotein-a [Lp(a)], high-sensitivity interleukin-6 (hsIL-6), monocyte chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), soluble Fas (sFas), soluble Fas ligand (sFasL), and plasma oxidized low-density lipoproteins (oxLDL) levels were determined. Results: VEM treatment resulted in a significant decrease in CRP, IL-6, sICAM-1 at 3 months, and oxLDL at 6 months, compared to baseline. Simvastatin resulted in a significant decrease in CRP, which correlated with decreases in both total (r ¼ 0.87, p < 0.05) and low-density lipoprotein cholesterol, IL-6, sICAM-1, sVCAM-1, oxLDL, and sFas at 6 months, compared to baseline. Simvastatin effects on sVCAM-1 (mean difference ¼ 652 ng/mL; 95% CI ¼ 294 to 2686; p < 0.05) and sFas (mean difference ¼ 1284 pg/mL; 95% CI ¼ 510 to 1910; p < 0.05) differed significantly from the corresponding VEM effects. Conclusions: The 6-month use of VEM resulted in more direct and immediate anti-inflammatory effects compared with those caused by the 6-month treatment with simvastatin. Simvastatin caused a more intense decrease in the markers of inflammation, which was in part correlated with its lipid-lowering effects.

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Vitamin E-coated cellulose acetate dialysis membrane: long-term effect on inflammation and oxidative stress

Abstract: Vitamin E supplementation by vitamin E-coated CAE dialysis membrane suppresses oxidative stress and inflammation.

Cited by 34 publications

References 39 publications

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Vitamin E as a Functional and Biocompatibility Modifier of Synthetic Hemodialyzer Membranes: An Overview of the Literature on Vitamin E-Modified Hemodialyzer Membranes

The Effects of Vitamin E-Coated Membrane Dialyzer Compared to Simvastatin in Patients on Chronic Hemodialysis

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