Vitamin E deficiency in the monkey

Cd, Fitch; Js, Dinning; Fs, Porter; Folkers, Karl; Hw, Moore; Jl, Smith

doi:10.1016/0003-9861(65)90085-8

Cited by 28 publications

(2 citation statements)

References 10 publications

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“…Bieri (14) determined the tissue vitamin E levels of a large number of rats fed diets with varying amounts of vitamin E. This method requires the killing of many animals and is impractical for research on more expensive animals. Vitamin E studies on primates (15,16) utilized analysis of hemoglobin and reticulocytes obtained from blood samples. The method of analysis of blood and fat samples to determine the dynamics of vitamin E depletion and repletion was employed in a study of human subjects (17).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary antioxidants on in vivo lipid peroxidation in the rat as measured by pentane production

Downey

Irving

Tappel

1978

Lipids

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The hypothesis that pentane is an in vivo product of lipid peroxidation was confirmed by a study of the effects of a nonbiological antioxidant on pentane production in rats fed a diet deficient in vitamin E and supplemented with 0.0/% N,N'-diphenyl-p-phenylenediamine (DPPD). Seven rats were fed a vitamin E-deficient diet starting at 3 wk of age. After 5 wk, 0.01% DPPD was added to the diets of three rats (group DPPD) while the diet of the other four rats remained unchanged (group OE). Within 2 wk of the diet change, rats in group DPPD exhaled 65% less pentane than rats of the same age in group OE. After 5 wk of being fed the DPPD-supplemented diet, rats in group DPPD were again fed the basal vitamin E-deficient diet; within 3 wk, these rats produced pentane levels similar to those of rats in group OE. The effects of vitamin E depletion and repletion on in vivo lipid peroxidation in rats were also studied. Three groups of three rats each were initially led a vitamin E-deficient diet starting at 3 wk of age. After 8, 8, and 5 wk of being fed this diet, the three groups were led diets supplemented with 3.3 (group 0--~3.3E), 11 (group 0--,11E), and 200 (group 200E) i.u. vitamin E acetate]kg diet, respectively. Another group of three rats (group 11 E) was fed a diet supplemented with 11 i.u. vitamin E/kg starting at 3 wk of age for the duration of the study. There were significant decreases in pentane production by rat groups 0-*3.3E, 0-*11E, and 200E within 2 wk of the change to the vitamin E-supplemented diets. After about 5 wk of being fed their respective vitamin E-supplemented diets, pentane breath levels had stabilized. Breath pentane levels were inversely proportional to the log of dietary vitamin E concentration.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary antioxidants on in vivo lipid peroxidation in the rat as measured by pentane production

Downey

Irving

Tappel

1978

Lipids

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“…"Of all the sciences contributing to medicine, chemistry is the primary one, and, apart from the general light it throws on the entire 16 THE IMPACT OF NATURAL PRODUCT CHEMISTRY ON MEDICINE art of healing, it will soon bestow on some of its branches a perfection such as one never could have anticipated. "…”

Section: Control Animalsmentioning

confidence: 99%

The Impact of Natural Product Chemistry on Medicine

FOLKERS¹

1967

The Chemistry of Natural Products

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Isomers of alpha‐tocopheryl acetate and their biological activity

Ames

1971

Lipids

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α‐Tocopheryl acetate, an ester of the naturally occurring form of vitamin E, has a biopotency of 1.66 IU/mg as determined by bioassays based on biological function. On a similar basis, 2l‐α‐tocopheryl acetate, the 2‐epimer of α‐tocopheryl acetate, has a biopotency of 0.35 IU/mg. Results of hemolysis bioassays indicate relative activities of 1.53 and 0.56 for α‐ and 2l‐α‐tocopheryl acetates, respectively, compared with 2dl‐ or all‐rac‐α‐tocopheryl acetate. Responses to plasma and liver storage tests average 1.35 for α‐tocopheryl acetate compared with all‐rac‐α‐tocopheryl acetate. The configuration at C‐2 is most important but the configurations at C‐4’ and C‐8’ may also be important in determining biopotency. There is no evidence of synergism between α‐tocopheryl acetate and 2l‐α‐tocopheryl acetate. Since the two isomers comprising 2dl‐α‐tocopheryl acetate, the former International Standard, have different rates of absorption, tissue storage, metabolism and excretion, a better standard for vitamin E is needed. α‐Tocopheryl acetate has both the chemical and biological properties required for a new International Standard for vitamin E. Redefinition of an International Unit in terms of 1 IU=0.60 mg of α‐tocopheryl acetate would give a precise reference for future research and a reasonable correlation with data collected in the past.

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Vitamin E deficiency in the monkey

Cited by 28 publications

References 10 publications

Effects of dietary antioxidants on in vivo lipid peroxidation in the rat as measured by pentane production

Effects of dietary antioxidants on in vivo lipid peroxidation in the rat as measured by pentane production

The Impact of Natural Product Chemistry on Medicine

Isomers of alpha‐tocopheryl acetate and their biological activity

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