Vitamin E does not reduce the side‐effects of isotretinoin in the treatment of acne vulgaris

Kus, Sadiye; Gün, Dilek; Demirçay, Zeynep; Sur, Haydar

doi:10.1111/j.1365-4632.2004.02072.x

Cited by 27 publications

(20 citation statements)

References 11 publications

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“…6,10 Supporting previous results, in the current study, major antioxidant enzyme GSH-Px activity, GSH in erythrocytes and LP were analysed in both erythrocytes and plasma as oxidative stress parameters under isotretinoin therapy as well as plasma antioxidant vitamins. Unlike the above studies, Kus et al 35 reported that acne vulgaris patients receiving 1 mgÁkg -1Áday -1 of isotretinoin therapy could not minimize adverse mucocutaneous side effects such as facial erythema, facial dryness, chelitis and serum lipid and liver enzyme profiles by the addition of 800 IUÁday -1 vitamin E in 60 recalcitrant nodular acne patients. Lipid peroxides are the initial products when lipids are damaged by ROS.…”

Section: Discussionmentioning

confidence: 95%

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Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

Erturan

Nazıroğlu

Akkaya

2012

Cell Biochemistry & Function

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Acne vulgaris is the one of the most common skin diseases. Although isotretinoin (13-cis-retinoic acid) is an effective and well-tolerated medication, it has a wide range of side effects. Because the effects of isotretinoin on oxidant and antioxidant systems have not yet been clarified, we investigated plasma and erythrocyte antioxidant vitamins, lipid peroxidation (LP), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) values in patients with acne vulgaris before and after isotretinoin treatment. The study was performed on the blood plasma and erythrocytes of 31 acne vulgaris patients. Blood samples were taken from the patients before treatment and after isotretinoin (oral and 0·5-0·7 mg·kg(-1)) treatment for 2 months. Plasma amtioxidant vitamins, erythrocyte malondialdehyde, GSH and GSH-Px levels were measured. Plasma vitamin E (p < 0·001), lipid peroxidation (LP) and serum high-density lipoprotein cholesterol (p < 0·001) values were significantly lower in the treatment group than in the pre-treatment group, although erythrocyte LP (p < 0·001), GSH (p < 0·01) and GSH-Px (p < 0·001), aspartate aminotransferase (p < 0·05), alanine aminotransferase (p < 0·05), density lipoprotein cholesterol (p < 0·001) and total cholesterol (p < 0·01) levels were significantly higher in the treatment group than in the pre-treatment group. Vitamins A, C and β-carotene concentrations did not change significantly between the two groups. In conclusion, the results of the current study indicate that isotretinoin treatment induces oxidative stress and liver damage by decreasing plasma vitamin E and increasing erythrocytes GSH-Px, GSH and liver enzyme values.

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Section: Discussionmentioning

confidence: 95%

“…In plasma, HDL-cholesterol is the major carrier of lipid peroxides. 35,36 . Hence, plasma LP was found to be lower depending on lower levels of HDL in the treatment group.…”

Section: Discussionmentioning

confidence: 99%

Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

Erturan

Nazıroğlu

Akkaya

2012

Cell Biochemistry & Function

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“…There have been various studies investigating potential treatments for isotretinoin-associated cheilitis, including vitamin E supplementation, evening primrose supplementation, and administering lower doses of isotretinoin in an attempt to mitigate side effects. Yet, there are currently no evidence-based effective or preventative treatment options for isotretinoin associated cheilitis [5, 10, 12–13]. Therefore there is a significant need for the development of novel treatment options.…”

Section: Discussionmentioning

confidence: 99%

Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale

Ornelas

Rosamilia

Larsen

et al. 2015

Journal of Dermatological Treatment

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Importance Isotretinoin remains an effective treatment for severe acne. Despite its effectiveness, it includes many side effects, of which cheilitis is the most common. Objective To develop an objective grading scale for assessment of isotretinoin-associated cheilitis, Design Cross-sectional clinical grading study. Setting UC Davis Dermatology clinic. Participants Subjects were older than 18 years old and actively treated with oral isotretinoin. Exposures Oral Isotretinoin. Main outcomes and Measures We developed an isotretinoin cheilitis grading scale (ICGS) incorporating the following four characteristics: erythema, scale/crust, fissures, and inflammation of the commissures. Three board-certified dermatologists independently graded photographs of the subjects. Results The Kendall’s coefficient of concordance (KCC) for the ICGS was 0.88 (p<0.0001). The Kendall’s coefficient was ≥ 0.72 (p<0.0001) for each of the four characteristics included in the grading scale. An image-based measurement for lip roughness statistically significantly correlated with the lip scale/crusting assessment (r = 0.52, p <0.05). Conclusion and Relevance The ICGS is reproducible and relatively simple to use. It can be incorporated as an objective tool to aid in the assessment of isotretinoin associated cheilitis.

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“…Isotretinoin (13-cis retinoic acid) belongs to a group of drugs known as retinoids, which are derivatives of vitamin A. Isotretinoin decreases the size and activity of the sebaceous glands in the skin, thus reducing the amount of sebum produced by the sebaceous glands [1]. Acne vulgaris is common among adolescents and young adults and isotretinoin is frequently administered for this condition.…”

mentioning

confidence: 99%

“…It is the rst-line treatment for extensive and nodulocystic acne [2]. Isotretinoin is also used in moderate acne that is unresponsive to conventional treatment and in patients with obvious scarring [1]. Isotretinoin has adverse e ects on the mucosae, eyes, skin, liver and the musculoskeletal system.…”

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confidence: 99%

The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study

Mehmet¹,

Akkurt²,

Gül³

et al. 2014

CIM

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e e ects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study AbstractPurpose: e purpose of this study was to investigate the e ect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations.Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. e hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks a er treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears).Results: e di erences between the mean values of the pre-treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi cant (p<0.05), but there was no signi cant di erence between the pretreatment and post-treatment values at 250 and 500 Hz frequencies (p>0.05). e di erence between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not signi cantly di erent (p>0.05). Conclusion:Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin-induced neurophysiological alterations in hearing.

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Vitamin E does not reduce the side‐effects of isotretinoin in the treatment of acne vulgaris

Abstract: Eight hundred IU/day vitamin E did not improve the side-effects of 1 mg/kg/day of isotretinoin in the treatment of acne vulgaris.

Cited by 27 publications

References 11 publications

Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale

The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study

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