Vitamin E in Angina Pectoris

Fat-Soluble Vitamins

“…Shute, however, has remained confident that his claims are well justified, and has supported them in an account of the. treatment of coronary heart disease (147), and in a review of the physiological and biochemical basis underlying the use of the vitamin in cardio-vascular diseases (148).…”

Alpha Tocopherol (Vitamin E) in the Treatment of Acute Thrombophlebitis

“…SINCE our first report (Shute, Shute, and Vogelsang, 1946/8) on the value of high dosage alpha tocopherol in the management o f thrombophlebitis, other observations on this subject have been presented (Shute et al, 1948;Shute, 1949; Shute and Shute, 1950;Cameron, 1950). Various confirmatory reports have now appeared.…”

Failure of Alpha Tocopherol to Influence Chest Pain in Patients with Heart Disease

“…This concept was supported by the fact that animals deprived of vitamin E show reversible changes in both cardiac'" 12 and skeletal"3 14 musculature, and by reports on the usefulness of vitamin E in the muscular dvstrophies and somatic pain syndromes such as filbromyositis. [5][6][7][8][9][10][11][12][13][14][15][16][17][18] We decided, therefore, to classify chest pain in our cardiac patients according to visceral and somatic components, and to evaluate by the blind-test method the effect of alpha tocopherol on these components in parallel series of control and treated subjects. The need for such a blind-test study is emphasized by Vogelsang, Shute and Shute themselves,9 as well as by recent editorial comment.…”