Vitamin E in the Menopause

McLaren, H. C.

doi:10.1136/bmj.2.4641.1378

Cited by 32 publications

(5 citation statements)

References 5 publications

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“…It is to be noted from the data in Table 1 and Figure 2 that vitamin E is no more effective than a placebo. This is in contrast to earlier reports on the therapeutic effectiveness of vitamin E in the climacteric (8)(9)(10)(11)(12)(13)(14)(15)(16). Further evaluation of vitamin E and comparison of the estrone sulfates, crystalline and noncrystalline equivalent compounds, will be discussed in subsequent reports.…”

Section: The Menopausal Indexcontrasting

confidence: 85%

Comparative Clinical Evaluation of Estrogenic Preparations by the Menopausal and Amenorrheal Indices*†

Kupperman

Blatt

Wiesbader

et al. 1953

The Journal of Clinical Endocrinology & Metabolism

427

188

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Section: The Menopausal Indexcontrasting

confidence: 85%

Comparative Clinical Evaluation of Estrogenic Preparations by the Menopausal and Amenorrheal Indices*†

Kupperman

Blatt

Wiesbader

et al. 1953

The Journal of Clinical Endocrinology & Metabolism

427

188

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“…In another study, McLAREN et al . [ 38 ] stated that long-term use of vitamin E can improve dyspareunia and reduce atrophic ulcers in the lower reproductive system of postmenopausal women. Costantino et al .…”

Section: Discussionmentioning

confidence: 99%

The effect of conjugated estrogens vaginal cream and a combined vaginal cream of vitamins D and E in the treatment of genitourinary syndrome

Hosseini

Radnia

Vafaei

et al. 2023

Journal of Family Medicine and Primary Care

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A BSTRACT Background and Aim: Genitourinary syndrome occurs due to a decrease in ovarian hormones; this can have a significant negative impact on women’s interpersonal relationships and sexual function. The present study aimed at comparing the therapeutic effect of conjugated estrogens vaginal cream and a combined vaginal cream of vitamins D and E in the treatment of genitourinary syndrome in postmenopausal women. Methods: This study was conducted as a double-blind randomized clinical trial (RCT). As many as 64 postmenopausal women suffering from genitourinary syndrome were randomly divided into study and control groups. The study group was treated with a combined vaginal cream of vitamins D and E, and the control group was treated with conjugated estrogens vaginal creams for 12 weeks. The patients were visited at the beginning of being admitted, the fourth week, the 12 th week, and four weeks after the treatment and their information was recorded by checklists and a sexual function questionnaire. The data were finally analyzed by SPSS-25 at a significant level of 0.05. Result: At four visits, libido, orgasm, and frequency of sexual intercourses, as well as vaginal symptoms such as burning, itching, dryness, and dyspareunia were improved in both groups ( P <.05). However, there was no difference between the two groups in terms of the frequency of severity of these symptoms during the four visits ( P >.05). Investigating the female sexual function index showed that using vitamin D and E vaginal creams, like the use of conjugated estrogens vaginal creams, improves sexual function in women ( P <.01). Conclusion: According to the results, it can be concluded that the combined vaginal cream of vitamins D and E is a suitable alternative to vaginal estrogens in relieving the symptoms of genitourinary syndrome in postmenopausal women, especially those who are unable to use hormone therapy or have little compatibility with this therapy.

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“…The present findings concur with the results presented by Constantino et al [ 30 ], who also revealed burning and itching after the same intervention. Additionally, McLaren et al [ 31 ] reported that the long-term application of vitamin E can improve symptoms of vulvovaginal lesions and reduce dyspareunia by enhancing atrophic scars in the lower reproductive tract. The alleviation of vulvovaginal lesions might be associated with biological properties of tocopherols.…”

Section: Discussionmentioning

confidence: 99%

Interventions Preventing Vaginitis, Vaginal Atrophy after Brachytherapy or Radiotherapy Due to Malignant Tumors of the Female Reproductive Organs—A Systematic Review

Wierzbicka

Mańkowska-Wierzbicka

Cieślewicz

et al. 2021

IJERPH

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Background: Radiotherapy, as a method of treatment of cervical and uterine cancers, may induce severe late-onset vaginal side effects. Unfortunately, little evidence on the management of adverse effects has been presented. This study aimed to evaluate the available interventions which reduce symptoms of vaginitis and vaginal atrophy by improving dyspareunia, mucosal inflammation, vaginal pH and vaginal dryness in women who have undergone brachytherapy or radiotherapy due to uterine or cervical malignancies. Materials and methods: A comprehensive literature search was performed following PRISMA guidelines. The systematic search was conducted using electronic databases, namely Scopus, Web of Science and PubMed, between October and November 2020 to identify randomized controlled trials (RCT) and, prospective randomized studies (PRS). Results: The analyzed population consists of 376 patients with uterine or cervical cancer, treated with hyaluronic acid, vitamin A, vitamin E, alpha-tocopherol acetate and dienestrol. Intervention with HA along with vitamin A and vitamin E revealed advantage in endpoints such as reduced dyspareunia, vaginal mucosal inflammation, vaginal dryness, bleeding, fibrosis and cellular atypia. Administration of alpha-tocopherol acetate reduced vaginal mucosal inflammation and improved vaginal acanthosis, whereas dienestrol resulted in reduced dyspareunia, vaginal caliber and bleeding. Conclusions: Vaginal suppositories were found to be clinically effective at the management of late-onset vulvovaginal side effects after radiotherapy.

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Vitamin E in the Menopause

Cited by 32 publications

References 5 publications

Comparative Clinical Evaluation of Estrogenic Preparations by the Menopausal and Amenorrheal Indices*†

Comparative Clinical Evaluation of Estrogenic Preparations by the Menopausal and Amenorrheal Indices*†

The effect of conjugated estrogens vaginal cream and a combined vaginal cream of vitamins D and E in the treatment of genitourinary syndrome

Interventions Preventing Vaginitis, Vaginal Atrophy after Brachytherapy or Radiotherapy Due to Malignant Tumors of the Female Reproductive Organs—A Systematic Review

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