Vitamin E in the Treatment of Tardive Dyskinesia: A Replication Study

Lam, Linda Chiu Wa; Chiu, Helen F.K.; Hung, Shun-Fa

doi:10.1097/00005053-199402000-00009

Cited by 35 publications

(25 citation statements)

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“…Ten randomized trials comparing vitamin E with placebo were included. [84][85][86][87][88][89][90][91][92][93] The overall results for clinically relevant improvement found no benefit of vitamin E against placebo (6 trials, N ¼ 256; RR, 0.95; 95% CI, 0.89-1.02). Similarly, for the outcome of any improvement in TD symptoms, no difference in favor of vitamin E was found (7 trials; N ¼ 311; RR, 0.86; 95% CI, 0.75-1.00).…”

Section: Neuroleptic Cessation As a Treatment For Tardivementioning

confidence: 99%

Tardive Dyskinesia

Soares‐Weiser¹,

Fernández

2007

Semin Neurol

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This article provides up-to-date information regarding clinical manifestations, pathophysiology, and evidence-based treatment for tardive dyskinesia (TD). We conducted a comprehensive literature search, including sources such as the Cochrane Library, EMBASE, and Medline; and we manually searched bibliographic references. We also contacted the authors of each included trial. All randomized clinical trials that compared different types of active interventions with placebo or no intervention in patients with neuroleptic-induced TD were included in our data. Two reviewers independently applied the selection criteria to all identified references, appraised the methodological quality of each trial, and extracted the relevant data. Relative risks and 95% confidence intervals were estimated using the fixed effect model. More than 500 randomized trials evaluating over 90 different interventions to treat TD were identified. From those, 45 trials were included in the current reviews. None of the trials pooled on these reviews found a definitive therapy for TD. Clinicians faced with conditions such as TD should carefully weigh the risks and benefits involved with any given intervention.

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Section: Neuroleptic Cessation As a Treatment For Tardivementioning

confidence: 99%

Tardive Dyskinesia

Soares‐Weiser¹,

Fernández

2007

Semin Neurol

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“…Treatment of the same patients with placebo resulted in a decrease in AIMS score from 9.09 ± 4.25 (range, 3-21) to 8.32±4.18 (range, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Resultsmentioning

confidence: 99%

“…The effects of melatonin (a mean decrease of 2.45±1.92 with melatonin compared with 0.77 ± 1.11 with placebo from baseline scores of 10.27 ± 5.38 and 9.09 ± 4.25, respectively) compare favorably with those attained by treatment with vitamin E (1200 IU/d) for the same period (6 weeks). With vitamin E, mean improvement in the AIMS score was reported to be 1.2 to 2.0 vs 0.2 to 2.0 with placebo, 9,[17][18][19][20][21][22] but the significance of vitamin E treatment vs placebo was not unequivocally demonstrated. It remains to be studied whether the efficacy of melatonin will further increase with longer treatment or with larger doses of the hormone.…”

Section: Commentmentioning

confidence: 99%

Melatonin Treatment for Tardive Dyskinesia

Shamir

Barak²,

Shalman³

et al. 2001

Arch Gen Psychiatry

138

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“…Six (from 13) studies for reducing EPSs, while using antipsychotics, showed a decrease of TD ( Adler et al, 1993 ; Akhtar et al, 1993 ; Dabiri et al, 1994 ; Egan et al, 1992 ; Elkashef et al, 1990 ; Lohr and Caligiuri 1996 ) and EPS (one study; Elkashef et al, 1990 ), and those with shorter duration of TD seemed to improve more; no adverse effects of vitamin E were reported, except mild diarrhea in two studies. Five (from five) reported no effect on general psychopathology ( Adler et al, 1999 ; Dorevitch et al, 1997a ; Elkashef et al, 1990 ; Lam et al, 1994 ; Lohr and Caligiuri, 1996 ). One study of melatonin for TD reported a decrease of TD and no adverse effects ( Shamir et al, 2001 ).…”

Section: Reviewmentioning

confidence: 99%

“…Thirteen studies of vitamin E were found ( Adler et al, 1993 , 1999 ; Akhtar et al, 1993 ; Dabiri et al, 1994 ; Dorevitch et al, 1997a , 1997b ; Egan et al, 1992 ; Elkashef et al, 1990 ; Lam et al, 1994 ; Lohr and Caligiuri, 1996 ; Salmasi et al, 2009 ; Schmidt et al, 1991 ; Shriqui et al, 1992 ). Six (from 13) studies for reducing EPSs, while using antipsychotics, showed a decrease of TD ( Adler et al, 1993 ; Akhtar et al, 1993 ; Dabiri et al, 1994 ; Egan et al, 1992 ; Elkashef et al, 1990 ; Lohr and Caligiuri 1996 ) and EPS (one study; Elkashef et al, 1990 ), and those with shorter duration of TD seemed to improve more; no adverse effects of vitamin E were reported, except mild diarrhea in two studies.…”

Section: Reviewmentioning

confidence: 99%

Natural Medicines for Psychotic Disorders

Hoenders¹,

Bartels-Velthuis²,

Vollbehr³

et al. 2018

J Nerv Ment Dis

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Patients with psychotic disorders regularly use natural medicines, although it is unclear whether these are effective and safe. The aim of this study was to provide an overview of evidence for improved outcomes by natural medicines. A systematic literature search was performed through Medline, PsycINFO, CINAHL, and Cochrane until May 2015. In 110 randomized controlled trials, evidence was found for glycine, sarcosine, N-acetylcysteine, some Chinese and ayurvedic herbs, ginkgo biloba, estradiol, and vitamin B6 to improve psychotic symptoms when added to antipsychotics. Ginkgo biloba and vitamin B6 seemed to reduce tardive dyskinesia and akathisia. Results on other compounds were negative or inconclusive. All natural agents, except reserpine, were well tolerated. Most study samples were small, study periods were generally short, and most results need replication. However, there is some evidence for beneficial effects of certain natural medicines.

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Vitamin E in the Treatment of Tardive Dyskinesia: A Replication Study

Cited by 35 publications

References 0 publications

Tardive Dyskinesia

Tardive Dyskinesia

Melatonin Treatment for Tardive Dyskinesia

Natural Medicines for Psychotic Disorders

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