Vitamin E-Induced Changes in Glutamate and GABA Metabolizing Enzymes of Chick Embryo Cerebrum

Pereira, Ivy; Dessai, Shanti N.; Pinto, Annaliza

doi:10.1155/2013/851235

Cited by 5 publications

(6 citation statements)

References 31 publications

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“…Vitamins D and E have powerful antioxidants (28,37), anti-inflammatory (41), and neurotransmitter regulatory effects (26,37). For the GABA inhibitory system, vitamin E creates a balance in activates of the enzymes converting glutamate to GABA in different brain regions (42); also, mice with vitamin D deficiency have shown a large decrease in GAD 65/67 expression in the whole brain. The balance in the activity of the GABA inhibitory system has an important effect on the neurogenesis and development of the brain (43).…”

Section: Discussionmentioning

confidence: 99%

Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring

Abbarin

Vafaei

Pour

et al. 2023

Middle East J Rehabil Health Stud

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Background: Autism spectrum is a type of developmental-neurodegenerative disease commonly reflected in social communications and associated with oxidative stress in the brain. Vitamins D and E, as strong antioxidants, may improve autistic-like behavioral disorders. Objectives: The aim of this study was to determine the effects of vitamins D and E on pain, threshold, motor coordination, and anxiety behavior, as well as oxidative stress parameters in an autistic model in rats. Methods: We induced an experimental model of congenital autism in the rat by injection of valproic acid (500 mg/kg) into pregnant rats on the day 12.5th of gestation. From postnatal day 30 to 60, male offspring received daily injections of vitamins D (5 µg/kg) and/or E (10 mg/kg) or vehicle. Next, their anxiety levels were assessed with the elevated plus maze and open field, pain thresholds with hot plate, motor and balance with rotarod, and spatial learning and memory with T-maze. The rat brain was then removed to measure oxidative markers, including Malondialdehyde, Glutathione, and Catalase. Results: Results indicated that injection of valproic acid-induced autistic-like behaviors, including increased pain threshold, increased anxiety, decreased exploring behaviors, reduced balance power, and motor learning, and produced oxidative stress. Administration of vitamins D and E significantly ameliorated these symptoms. Conclusions: These findings may indicate that vitamins D and E improved sensory, motor, anxiety, and cognitive deficits in an experimental model of autism, probably by reducing the oxidative stress and inflammatory process or maintaining balance in the neurotransmitter system.

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Section: Discussionmentioning

confidence: 99%

Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring

Abbarin

Vafaei

Pour

et al. 2023

Middle East J Rehabil Health Stud

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“…Vitamins D and E are also involved in metabolic activities. Vitamin D regulates calcium homeostasis [71], while vitamin E regulates the activation of protein kinase C [72,73]. Minerals, including boron, fluoride and selenium, also regulate several metabolic activities that are essential to hormonal, vitamin and magnesium activities [74].…”

Section: Metabolic Activitiesmentioning

confidence: 99%

“…While vitamins B9, B12 and C are essential for the synthesis of monoamines, boron and iron are crucial for motor and cognitive development, performance and protection [21,22]. The B vitamins are involved in synthesis of catecholamines and gamma-amino glutamic acid (GABA), while vitamin D is involved in the formation and utilisation of glutamine [22,73,[75][76][77]. Calcium, chloride, magnesium, potassium and sodium are necessary for neural and synaptic transmission [78].…”

Section: Neuronal and Brain Functionmentioning

confidence: 99%

“…Therefore, micronutrients can be used in the treatment of cardiovascular disease, and their supplementation also improves patients with cardiovascular disease and cancers [8,72,73,[100][101][102]. Micronutrient supplementation can also reduce the risk of pre-eclampsia and high blood pressure in pregnant women [103,104] and improve arterial blood pressure in diabetic and non-diabetic patients [105][106][107][108].…”

Section: Micronutrient Supplements For Communicable and Non-communica...mentioning

confidence: 99%

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Exploring micronutrient supplements in disease conditions: are they effective?

Ekong,

Nwakanma,

Iniodu

2024

FNDS

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Nutrition is essential for the health and well-being of all living beings and is sourced from foods of different origins and types. Most importantly, the food must contain carbohydrates, proteins, fat, vitamins and minerals in a balanced form to achieve optimum benefits. Vitamins and minerals, also known as micronutrients, are characterised by their nature, quantity and role in normal metabolic activities. In humans, micronutrients are exclusively obtained from food or supplements. In addition, vitamin D3 is synthesized de novo with the aid of sunlight, while vitamins B and K are synthesized in the gut by the resident bacteria. Micronutrients play an important role in health and disease states and have become the most widely used dietary supplements in the world. However, how effective they are against diseases is controversial as conflicting reports continue to emerge, especially where insufficient data is available. This review highlights the important role of micronutrient supplements in the alleviation of communicable and non-communicable diseases. Data were retrieved from the literature in databases including African Journal Online, Google Scholar, PubMed and Web of Science, among others, with hits on nutrients, vitamins and mineral supplements: Only literature with relevant information from 1993-2023 (30 years) was considered. As important as these micronutrients are for health and their supplementations are generally beneficial, it is worthy of note that their role in the disease treatment is still limited by insufficient data.

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“…It also maintains neurological structure and function ( Muller and Goss-Sampson, 1990 ). Its deficiency associated with depression symptoms, alters the levels of glutamate and GABA in developmental neurogenesis by inducing changes in the enzymes involved in their metabolism ( Pereira et al, 2013 , Banikazemi et al, 2015 ). Vitamin E intake reduces depressive symptoms ( Banikazemi et al, 2015 , Nguyen et al, 2017 ).…”

Section: Application Of Nutrition In Depression Managementmentioning

confidence: 99%

Nutritional therapy can reduce the burden of depression management in low income countries: A review

Ekong

Iniodu

2021

IBRO Neuroscience Reports

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Depression is a serious mental and mood disorder with global health and economic burden. This burden may be overwhelming in low income countries, although there are insufficient data. Most antidepressant formulations are predicated on the monoamine, neuroendocrine and neuro-inflammation hypotheses, with little or no cognizance to other neurochemicals altered in depression. A nutritional strategy with or without conventional antidepressants is recommended, as nutrition plays vital roles in the onset, severity and duration of depression, with poor nutrition contributing to its pathogenesis. This review discusses nutritional potentials of utilizing omega-3 fatty acids, proteins, vitamins, minerals and herbs or their phytochemicals in the management of depression with the aim of reducing depression burden. Literature search of empirical data in books and journals in data bases including but not limited to PubMed, Scopus, Science Direct, Web of Science and Google Scholar that might contain discussions of sampling were sought, their full text obtained, and searched for relevant content to determine eligibility. Omega-3 fatty and amino acids had significant positive anti-depression outcomes, while vitamins and minerals although essential, enhanced omega-3 fatty and amino acids activities. Some herbs either as whole extracts or their phytochemicals/metabolites had significant positive anti-depression efficacy. Nutrition through the application of necessary food classes or herbs as well as their phytochemicals, may go a long way to effectively manage depression. This therefore will provide inexpensive, natural, and non-invasive therapeutic means with reduced adverse effects that can also be applied alongside clinical management. This nutritional strategy should be given more attention in research, assessment and treatment for those with depression and other mental illness in low income countries, especially in Africa.

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Vitamin E-Induced Changes in Glutamate and GABA Metabolizing Enzymes of Chick Embryo Cerebrum

Cited by 5 publications

References 31 publications

Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring

Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring

Exploring micronutrient supplements in disease conditions: are they effective?

Nutritional therapy can reduce the burden of depression management in low income countries: A review

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