Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

Li‐Weber, Min; Giaisi, Marco; Treiber, M; Krammer, Peter H.

doi:10.1002/1521-4141(200209)32:9<2401::aid-immu2401>3.0.co;2-s

Cited by 106 publications

(56 citation statements)

References 44 publications

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“…This process is believed to result in the production of oxygen-free radicals (Seaton et al, 1994). In addition to its natural intra-and extracellular antioxidant defense systems, the lung depends on nutritional antioxidants to inhibit the propagation of the damages from these free radicals (Seaton et al, 1994;Li-Weber et al, 2002). In vitro studies suggest that the deficiency in dietary antioxidants may result in T-helper cell differentiation and the promotion of the Th2 cell types (Li-Weber et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to its natural intra-and extracellular antioxidant defense systems, the lung depends on nutritional antioxidants to inhibit the propagation of the damages from these free radicals (Seaton et al, 1994;Li-Weber et al, 2002). In vitro studies suggest that the deficiency in dietary antioxidants may result in T-helper cell differentiation and the promotion of the Th2 cell types (Li-Weber et al, 2002). Consequently, it has been hypothesized that inadequate intake of dietary antioxidants may contribute to the increasing frequency of allergies and asthma in industrialized countries (Seaton et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

et al. 2011

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Background/Objectives: The potential immune functions related to the damages induced by oxygen-free radicals suggest that antioxidants may have a role in the development of allergies. The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children. Subjects/Methods: This study was on the basis of the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with 5-year follow-up. Complete information on maternal food frequency questionnaire data and ISAAC (International Study of Asthma and Allergies in Childhood)-based allergic outcomes were available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. Results: Maternal intake of any of the antioxidants was not significantly associated with the risk of asthma, rhinitis or eczema in the offspring, except for dietary intake of magnesium, which was independently associated with protection against eczema (OR 0.78; 95% CI 0.62-0.97). Conclusion: Maternal intake of dietary magnesium during pregnancy may protect against the risk of eczema in the offspring. We did not confirm previous observations concerning other antioxidants. This may be due to the variable amount of antioxidant intake across studies and also indicative of the hypothesis that there may be a critical time window in pregnancy during which antioxidants might modify the risk of allergies in the offspring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

et al. 2011

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“…Third, a significant reduction in total serum IgE as well as significant attenuation of allergic airway inflammation were found in cRel -/-mice [14]. Furthermore, reagents that inhibit NF-‹ B activity suppress IL-4 production in peripheral blood T cells [15,16].…”

Section: Introductionmentioning

confidence: 99%

NF‐κB synergizes with NF‐AT and NF‐IL6 in activation of the IL‐4 gene in T cells

et al. 2004

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IL‐4 plays a pivotal role in the development of the Th2 cell mediated humoral immune response and causes IgE‐dependent allergic inflammatory diseases. Expression of IL‐4 in differentiated Th2 cells is regulated by transcription factors such as NF‐AT, AP‐1 and NF‐IL6. Recently, increasing evidence indicates that the pro‐inflammatory transcription factor NF‐κB may also participate inIL‐4 expression. In this study, we show that the IL‐4 promoter is synergistically activated by NF‐κB, NF‐AT and NF‐IL6 at the NF‐κB/NF‐AT/NF‐IL6 composite sites. In addition, we performed the chromatin immunoprecipitation technique to determine the functional relevance of NF‐κB in the activation of the IL‐4 gene in vivo. We demonstrate that NF‐κB binds to the IL‐4 promoter in vivo upon T cell activation. Inhibition of NF‐κB nuclear translocation in living cells blocked binding of NF‐κB to the IL‐4 promoter. The data provide first evidence that NF‐κB is directly involved in IL‐4 transcription.

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“…38,39 The antioxidant vitamin E can block binding of transcription factors to the binding sites and down-regulate IL-4 protein production. 40 42 However, the molecular mechanism of IL-4 gene transcription induced by HgCl 2 in mast cells remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Characterization of cis‐regulatory elements conferring mercury‐induced interleukin‐4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites

Pearson

Oliveira

2009

Immunology

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Summary We have previously shown that oxidative stress is involved in the pathogenesis of a mercuric chloride (HgCl2)‐induced, T helper type 2 (Th2)‐driven autoimmune syndrome in Brown Norway (BN) rats. In the context of the syndrome, the oxidative stress‐induced mast cell response seems to determine the development of the early phase of vasculitis, while oxidative stress‐mediated interleukin (IL)‐4 production may contribute to the subsequent Th2‐driven autoimmune response. However, the molecular basis of IL‐4 gene transcription induced by HgCl2 in mast cells remains unknown. In the present study, we dissect the critical regulatory mechanisms in the IL‐4 gene promoter in the rat mast cell line RBL‐2H3. Immunoprecipitation provided evidence that treatment with HgCl2 increased phosphorylation of signal transducer and activator of transcription 6 (STAT6). Transient transfection reporter analyses with a series of 5′ end deletions of the IL‐4 promoter produced evidence that STAT6 and TATA box binding sites are important in HgCl2‐induced IL‐4 gene expression. Subsequent elimination of one or both sites by site‐directed mutagenesis significantly inhibited IL‐4 promoter activity. Our results provide evidence that STAT6 and TATA box regulatory elements play an important role in HgCl2‐induced IL‐4 transcription in rat mast cells.

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Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

Cited by 106 publications

References 44 publications

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

NF‐κB synergizes with NF‐AT and NF‐IL6 in activation of the IL‐4 gene in T cells

Characterization of cis‐regulatory elements conferring mercury‐induced interleukin‐4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites

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