Vitamin-E Modified Cellulose Membrane.

Sasaki, Megumi; Hosoda, Tetsushi; Sugiyama, T.; Watanabe, Hiroshi; Tsukamoto, Hide; Saruhashi, Makoto

doi:10.5360/membrane.19.400

Cited by 10 publications

(12 citation statements)

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“…One of the factors influencing the latter is the antioxidant behaviour and in several cases the desired properties have been introduced through posttreatment of the existing membrane modules. The latter has proved to be a successful approach but functionalization takes place at the polymer surface, resulting in a relatively low degree of substitution (Sasaki et al 2000). To overcome this limitation, in the present studies we report on the bulk functionalization of microcrystalline cellulose, which is then used in a second step to prepare membranes with antioxidant activity by phase inversion.…”

Section: Introductionmentioning

confidence: 92%

“…Sasaki et al (2000) reported the use of dialysis membranes, derivatized with vitamine E moieties by post-treatment of the original regenerated cellulose membranes through reactive coupling with epoxy-functional vitamin E derivatives. The increased biocompatibility should reduce the complications that may occur during interaction of membranes with liquid streams (hemodialysis, hemofiltration, plasma fractionation); cells, tissues and organs (regenerative medicine, bioartificial organs).…”

Section: Antioxidant Membranes and Possible Applicationsmentioning

confidence: 99%

“…Due to several drawbacks there is a continuous search for new cellulose derivatives with higher blood compatibility and reduced cell adhesion (Sasaki et al 2000;Diamantoglou et al 1999;Hoenich et al 1997;Yuan et al 2003). Cellulose based membranes are also of interest for the development of artificial biohybrid systems containing biological derivates (cells, biomacromolecules).…”

Section: Cellulose With Antioxidant Propertiesmentioning

confidence: 99%

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Polymeric membranes with antioxidant activity based on cellulose esters and poly(vinylidene fluoride)/cellulose ester blends

et al. 2011

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A series of novel cellulose membranes with antioxidant activity was prepared and characterized. Microcrystalline cellulose was functionalized with lipoic acid, ferulic acid and alpha-tocopherol moieties. These materials were characterized by FT-IR and NMR spectroscopy and their degree of substitution (DS) was determined by volumetric analysis. The manuscript discusses the antioxidant activity of cellulose derivatives in inhibiting lipid peroxidation in ratliver microsomal membranes, induced in vitro by two different sources of free radicals: 2,2 0 -azobis-(2-amidinopropane) (AAPH), which exogenously produces peroxyl radicals by thermal decomposition, and tertbutyl hydroperoxide (tert-BOOH), which endogenously produces alkoxyl radicals by Fenton reactions. Membranes were prepared by the nonsolvent-induced phase inversion technique. Membranes of the pure cellulose derivatives were thin, mechanically weak and generally unsuitable for practical application. As an alternative, mechanically resistant poly(vinylidene fluoride)/cellulose ester blend membranes were obtained by direct phase inversion of the polymer/ polymer/solvent mixture. These membranes were characterized by means of water permeability measurements, optical and scanning electron microscopy, determination of the antioxidant activity in comparison with starting materials. The membranes exhibited a good preservation of peroxidation inhibition and the performance of this kind of cellulose membrane as a scavenger of Reactive Oxygen Species (ROS) offers interesting perspectives for an effective control of intradialytic oxidative stress.

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Section: Introductionmentioning

confidence: 92%

Section: Antioxidant Membranes and Possible Applicationsmentioning

confidence: 99%

Section: Cellulose With Antioxidant Propertiesmentioning

confidence: 99%

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Polymeric membranes with antioxidant activity based on cellulose esters and poly(vinylidene fluoride)/cellulose ester blends

et al. 2011

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“…Vitamin E (-tocopherol) was then bonded to oleic alcohol via hydrophobic interaction. Sasaki et al, 2000, reported the outline of the production process as well as the results of in vitro and in vivo studies on Excebrane, which showed much better biocompatibility than the original regenerated cellulose membrane.…”

Section: Developmentmentioning

confidence: 99%

Review of the Effectiveness of Cellulose- and Polysulfone-Based Vitamin E-Bonded Dialysis Membranes

Aritomi¹,

Galli²

2011

Technical Problems in Patients on Hemodialysis

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“…One is its poor blood compatibility, represented by complement activation occurring during extracorporeal circulation. [3][4][5] As a solution to this problem, many chemical modifications of the membrane surface have been proposed, and some of them have successfully been commercialized, such as the grafting of poly(ethylene glycol) 6,7 and the fixation of vitamin E. 8 The other is its low permeability for low molecular weight proteins. The excessive existence of certain proteins in blood causes many kinds of complications.…”

Section: Introductionmentioning

confidence: 99%

Hemodialysis membrane prepared from cellulose/N‐methylmorpholine‐N‐oxide solution. II. Comparative studies on the permeation characteristics of membranes prepared from N‐methylmorpholine‐N‐oxide and cuprammonium solutions

Abe

Mochizuki

2003

J of Applied Polymer Sci

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Two kinds of regenerated cellulose membranes for hemodialysis were prepared from casting solutions of N-methylmorpholine-N-oxide (NMMO) and cuprammonium (denoted NMMO membranes and cuprammonium membranes, respectively). The concentration of cellulose in the casting solution investigated was 6 -8 wt %. The permeation characteristics of both membrane series were compared in terms of the ultrafiltration rate (UFR) of pure water, the sieving coefficient (SC) of dextran, and the solute permeabilities of urea, creatinine, and vitamin B 12 . The UFR and SC of the NMMO membranes were strongly affected by the cellulose concentration of the casting solution, and NMMO was a preferable solvent for the production of cellulose membranes with high performance; the cuprammonium solution gave low-performance membranes. The pore structures of both types of membranes were estimated with the Hagen-Poiseuille law. The results showed that the NMMO membranes had larger pore radius and smaller pore numbers than the cuprammonium membranes. The differences in the membrane pore structures led to the differences in the performance between the two membrane series.

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Vitamin-E Modified Cellulose Membrane.

Cited by 10 publications

References 0 publications

Polymeric membranes with antioxidant activity based on cellulose esters and poly(vinylidene fluoride)/cellulose ester blends

Polymeric membranes with antioxidant activity based on cellulose esters and poly(vinylidene fluoride)/cellulose ester blends

Review of the Effectiveness of Cellulose- and Polysulfone-Based Vitamin E-Bonded Dialysis Membranes

Hemodialysis membrane prepared from cellulose/N‐methylmorpholine‐N‐oxide solution. II. Comparative studies on the permeation characteristics of membranes prepared from N‐methylmorpholine‐N‐oxide and cuprammonium solutions

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