Vitamin E slows down the progression of osteoarthritis

Abstract

Abstract. Osteoarthritis is a chronic degenerative joint disorder with the characteristics of articular cartilage destruction, subchondral bone alterations and synovitis. Clinical signs and symptoms of osteoarthritis include pain, stiffness, restricted motion and crepitus. It is the major cause of joint dysfunction in developed nations and has enormous social and economic consequences. Current treatments focus on symptomatic relief, however, they lack efficacy in controlling the progression of this disease, which is a leading cause of disability. Vitamin E is safe to use and may delay the progression of osteoarthritis by acting on several aspects of the disease. In this review, how vitamin E may promote the maintenance of skeletal muscle and the regulation of nucleic acid metabolism to delay osteoarthritis progression is explored. In addition, how vitamin E may maintain the function of sex organs and the stability of mast cells, thus conferring a greater resistance to the underlying disease process is also discussed. Finally, the protective effect of vitamin E on the subchondral vascular system, which decreases the reactive remodeling in osteoarthritis, is reviewed.

Nutrition and dietary supplements in the prevention of osteoarthritis

“…Pretpostavljeni mehanizmi protektivnog delovanja vitamina E na zglobove obuhvataju: održavanje normalne funkcije mišića, regulaciju metabolizma nukleinskih kiselina, stabilizaciju mastocita, kao i zaštitu subhondralnih krvnih sudova od oksidativnog oštećenja (26).…”

Impact of Dietary Supra-Nutritional Levels of Vitamins A and E on Fertility Traits of Broiler Breeder Hens in Late Production Phase

“…Vitamins also improve the immune status in birds and promote the normal metabolism in order to defend against disease and stress. Recent findings on the role of vitamin A [6][7][8] and E [9,10] on biological systems presented new viewpoints for requirements of both humans and animals to these nutrients. Vitamin A has been associated with the health and integrity of cell membranes, while vitamin E is often associated with the synthesis of various hormones, and in livestock species, it was a direct effect on gonadal function was reported [11,12].…”

Analysis of the prevalence and risk factors of osteoarthritis in a population

“…Считается, что важной причиной дисфункции хондроцитов и деградации суставного хряща является окислительный стресс, поэтому часть исследований посвящена изучению влияния витаминов С и Е, обладающих антиоксидантной активностью [59]. У пациентов с выраженными симптомами ОА коленных суставов назначение витамина Е в терапевтических дозах не сопровождалось достоверным клиническим улучшением и не предотвращало прогрессирование структурных изменений, которые оценивались с помощью МРТ [60].…”