Vitamin E TPGS as a molecular biomaterial for drug delivery

Zhang, Zhiping; Tan, Songwei; Feng, Si‐Shen

doi:10.1016/j.biomaterials.2012.03.046

Cited by 524 publications

(245 citation statements)

References 113 publications

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“…The faster drug release by NPs with higher TPGS-PLGA content may be attributed to higher hydrophilicity of the TPGS shell, allowing the release medium to easily penetrate the NPs and cause matrix swelling. [ 11 ] …”

Section: In Vitro Drug Release Kinetics Of This Dtx-loaded Np Systemmentioning

confidence: 97%

“…[ 10 ] Second, incorporation of TPGS can improve drug permeability through cell membranes by inhibiting P-gp, reduce P-gp-mediated MDR in tumor cells, and increase the absorption and bioavailability of anticancer drugs. [ 11 ] Furthermore, possessing a bulky structure and large surface area, TPGS can act as an excellent solubilizer, emulsifi er, bioavailability enhancer of hydrophobic drugs, thus increasing drug (e.g., taxanes, steroids, cyclosporines, and antibiotics) solubility. [ 11,12 ] Third, not only can we apply active targeting through FA conjugated PEG-b -PLGA, we can also adjust the ratio of different polymers to regulate controlled release of the drugs, signifi cantly increasing the local effective drug concentration.…”

Section: Introductionmentioning

confidence: 99%

“…[ 11 ] Furthermore, possessing a bulky structure and large surface area, TPGS can act as an excellent solubilizer, emulsifi er, bioavailability enhancer of hydrophobic drugs, thus increasing drug (e.g., taxanes, steroids, cyclosporines, and antibiotics) solubility. [ 11,12 ] Third, not only can we apply active targeting through FA conjugated PEG-b -PLGA, we can also adjust the ratio of different polymers to regulate controlled release of the drugs, signifi cantly increasing the local effective drug concentration. Therefore, the reported blended NP system can achieve the best therapeutic effi ciency in an extremely safe, simple and high effi cient process for cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

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Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy

Tao

Zhang

Zeng

et al. 2015

Adv Healthcare Materials

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A novel blended nanoparticle (NP) system for the delivery of anticancer drugs and its surprisingly high efficacy for cancer chemotherapy by blending a targeting polymer folic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (FA-PEG-b-PLGA) and a miscible structurally similar polymer D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactide-co-glycolide) (TPGS-PLGA) is reported. This blended NP system can be achieved through a simple and effective nanoprecipitation technique, and possesses unique properties: i) improved long-term compatibility brought by PEG-based polymers; ii) reduced multidrug resistance mediated by P-glycoprotein (P-gp) in tumor cells and increased bioavailability of anticancer drugs by incorporation of TPGS; iii) the regulation of controlled release through polymer ratios and active targeting by FA. Both in vitro cell experiments and in vivo antitumor assays demonstrated the reported blended NP system can achieve the best therapeutic efficiency in an extremely safe, simple and highly efficient process for cancer therapy. Moreover, this NP system is highly efficient in forming NPs with multiple functions, without repeated chemical modification of polymers, which is sometimes complex, inefficient and high cost. Therefore, the development of this novel blended NP concept is extremely meaningful for the application of pharmaceutical nanotechnology in recent studies.

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Section: In Vitro Drug Release Kinetics Of This Dtx-loaded Np Systemmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy

Tao

Zhang

Zeng

et al. 2015

Adv Healthcare Materials

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show abstract

“…These hkl values of HAP indexing with JCPDS file no.09-0432 showed a minimal line broadening and sharp intense peak, indicating a well crystallite material [10][11][12]. The absence other calcium phosphate (Tricalcium phosphate) peaks were observed in the patterns.…”

Section: Figure 1: Xrd Patterns Of Nano Hydroxyapatite Powdermentioning

confidence: 99%

Polyvinyl Alcohol-Nanobioceramic Based Drug Delivery System

Shaik¹,

Seethalakshmi²,

Kaviya³

et al. 2017

SOJMSE

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Drug delivery research today is an advanced and important area in pharmaceutical research and application of nanotechnology includes enhancement of the solubility and permeability of the drugs so as to improve their bioavailability including delivery to the targeted site. Hydroxyapatite (HAP) based bioceramic nanoparticles composed of biodegradable polymers have been used in the present work to develop an amoxicillin based delivery systems. The synthesized n-HAP powders were estimated for the Ca/p ratio. This ratio indicates the presence of HAP as a single phase. The nano structure, morphology and presence of vibrational groups are confirmed using instrumental analysis. The SEM images show the spherical shaped particles of nano hydroxyapatite are confirmed. The loading and unloading characteristics of the drug were recorded spectro photometrically. KeywordsNanofibres; Electrospinning; Polyvinyl Alcohol; Hydroxyapatite; Amoxicillin; IntroductionVarious technologies have been explored for different routes of administration such as oral, parenteral, nasal, dermal, vaginal, etc. Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. It has been reported that the ultimate therapeutic and toxic effects produced by a drug, when administered as a solid dosage form and the resultant benefit or risk to a patient, are dependent on the sum of several interacting variables associated with the pharmacological properties of the drug, physiological and pathological factors associated with the patient and the physicochemical properties of the dosage form [1,2]. Several researchers are, therefore, engaged in exploring the physicochemical aspects of dosage forms and their relationship with therapeutic efficacy [3,4]. Different types of drug delivery systems have been developed by manipulating the physicochemical properties such as particle size, compound lipophilicity, surface charge, etc. Several products are available in the market based on these technologies and a large number of products are in clinical trials but they are yet to reach the patients. In this context, nanotechnology has been shown to provide superior drug delivery systems for a better management and treatment of cancer and other diseases like AIDS, tuberculosis and malaria. Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. The application of nanotechnology in drug delivery research includes enhancement of the solubility and permeability of the drugs so as to improve their bioavailability including delivery to the targeted site like for example malignant tumour. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery...

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“…D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is as an amphiphilic copolymer used for the preparation of micelles because of its valuable advantages. TPGS is a derivative of the natural vitamin E (alphatocopherol), which is conjugated with polyethylene glycol (PEG) 1000 (Zhang et al, 2012;Vijayakumar et al, 2013;Kutty et al, 2015). TPGS is an efficient and safer macromolecule for the preparation of drug-and/or diagnostic material-loaded micelles.…”

Section: Introductionmentioning

confidence: 99%

Transferrin receptor-targeted vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats

et al. 2015

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The effective treatment of brain cancer is hindered by the poor transport across the blood-brain barrier (BBB) and the low penetration across the blood-tumor barrier (BTB). The objective of this work was to formulate transferrin-conjugated docetaxel (DTX)-loaded d-alpha-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS or TPGS) micelles for targeted brain cancer therapy. The micelles with and without transferrin conjugation were prepared by the solvent casting method and characterized for their particle size, polydispersity, drug encapsulation efficiency, drug loading, in vitro release study and brain distribution study. Particle sizes of prepared micelles were determined at 25 °C by dynamic light scattering technique. The external surface morphology was determined by transmission electron microscopy analysis and atomic force microscopy. The encapsulation efficiency was determined by spectrophotometery. In vitro release studies of micelles and control formulations were carried out by dialysis bag diffusion method. The particle sizes of the non-targeted and targeted micelles were <20 nm. About 85% of drug encapsulation efficiency was achieved with micelles. The drug release from transferrin-conjugated micelles was sustained for >24 h with 50% of drug release. The in vivo results indicated that transferrin-targeted TPGS micelles could be a promising carrier for brain targeting due to nano-sized drug delivery, solubility enhancement and permeability which provided an improved and prolonged brain targeting of DTX in comparison to the non-targeted micelles and marketed formulation.

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Vitamin E TPGS as a molecular biomaterial for drug delivery

Cited by 524 publications

References 113 publications

Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy

Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy

Polyvinyl Alcohol-Nanobioceramic Based Drug Delivery System

Transferrin receptor-targeted vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats

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