Vitamin E Treatment for Olanzapine Induced Tardive Dyskinesia in an Adolescent with Bipolar Disorder

Tufan, Ali Evren; Yalug, Irem; Bilici, Rabia

doi:10.5455/bcp.20121130085643

Cited by 1 publication

(1 citation statement)

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“…Some other hypothesis are reduced gamma amino butyric acid (GABA) turnover, increased GABA receptors in one or more domain of basal ganglia, neurotoxic outcomes of antipsychotics on brain, striatal dysregulation with altered D1 and D2 receptor ratio or increased noradrenergic and decreased cholinergic activity. 1 TD impacts 20-30% of patients during long-term antipsychotic therapy, with older patients beating up a higher risk. Atypical antipsychotics cause lower risk in terms of tardive dyskinesia compared to traditional neuroleptics nonetheless there is stil probability of late adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Olanzapine and tardive dyskinesia: a case report

Şahan¹,

Eroğlu²

2017

Anadolu Psikiyatri Derg

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Tardive dyskinesia is a serious and common motor side-effect of treatment with especially traditional neuroleptics with an unknown pathophysiological basis. The essential features of neuroleptic-induced tardive dyskinesia (TD) are abnormal, involuntary movements of the tongue, jaw, trunk or extremities that emerges in a patient predisposed to antipsychotic medication. Although the exact pathogenesis of TD is unclear, there is some evidence that dopamine supersensitivity in the nigro-striatal pathway due to the antipsychotics could contribute to these dyskinetic movements. Atypical antipsychotics have less risk in terms of tardive dyskinesia compared to traditional neuroleptics however there is stil probability of late adverse effects. Although it has been suggested that olanzapine can improve tardive dyskinesia in some patients, few reported cases have shown that the prolonged use of olanzapine can instead be associated with tardive dyskinesia/dystonia. Here we report a case who experienced tardive dyskinesia after 12 years of treatment with olanzapine and its treatment with clozapine.

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Section: Introductionmentioning

confidence: 99%