Vitamin K and Bone: Past, Present, and Future

Gundberg, Caren M.

doi:10.1359/jbmr.090312

Cited by 14 publications

(3 citation statements)

References 36 publications

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“…In contrast, most studies conducted in Caucasians reported insignificant effects of vitamin K1 intake on BMD, and Gundberg commented that vitamin K supplementation was unlikely to prevent fracture [25]. Thus, ethnic differences between Caucasians and Japanese, including dietary culture and environmental and genetic factors, may exist with regard to the effects of vitamin K intake on BMD or fracture risk [26].…”

Section: Role Of Vitamin K In Natto's Effect On Bone Healthmentioning

confidence: 99%

Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

et al. 2011

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Section: Role Of Vitamin K In Natto's Effect On Bone Healthmentioning

confidence: 99%

Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

et al. 2011

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“…An increased risk of all clinical fractures in older men and women with lower levels of fully carboxylated OC has also been reported (87). However, trials of vitamin K supplementation have generally failed to demonstrate an effect on fracture risk (88). Similarly, treatment with warfarin, a potent vitamin K antagonist that increases ucOC levels, has generally not been found to decrease BMD or bone strength in animal models (69, 89, 90).…”

Section: Clinical Studiesmentioning

confidence: 99%

Bone and glucose metabolism: A two-way street

Motyl

McCabe

Schwartz

2010

Archives of Biochemistry and Biophysics

100

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Evidence from rodent models indicates that undercarboxylated osteocalcin (ucOC), a product of osteoblasts, is a hormone affecting insulin production by the pancreas and insulin sensitivity in peripheral tissues, at least in part through enhanced secretion of adiponectin from adipocytes. Clinical research to test whether this relationship is found in humans is just beginning to emerge. Cross-sectional studies confirm associations between total osteocalcin (OC), ucOC and glucose metabolism but cannot distinguish causality. To date, longitudinal studies have not provided a consistent picture of the effects of ucOC or OC on fasting glucose and insulin sensitivity. Further exploration into the physiological and mechanistic effects of ucOC and OC, in rodent models and clinical studies, is necessary to determine to what extent the skeleton regulates energy metabolism in humans.

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“…Vit K acts as an enzymatic cofactor of a post‐transduction reaction by participating in the carboxylation of osteocalcin, which consequently indirectly increases osteoblastic activity, thus indicating benefits to bone formation (Gundberg, ). When a deficiency in vit K occurs, there is an increased production of decarboxylated osteocalcin, which is a weak binder of the hydroxyapatite of Ca, thus leading to a deficiency in bone mineralization (Price, ; Vermeer, ; Zhang et al., ).…”

Section: Introductionmentioning

confidence: 99%

Influence of graded levels of calcium and vitamin K in the diets of laying hens during the growing phase and their effects on the laying phase

Souza

Santos

Murakami

et al. 2016

Animal Physiology Nutrition

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The aim of this study was to evaluate the effect of dietary supplementation of vitamin K (vit K) and Ca in the diets of laying hens on bone and blood parameters and performance during the growing phase and the effects on the laying phase up to 32 weeks. The study utilized 120 Hy-Line W-36 pullets in the growing phase (13-18 weeks), 80 laying hens in the production phase (20-32 weeks), distributed in a completely randomized design in a 2 × 5 factorial arrangement, two levels of Ca (0.8 and 1.4%) and five levels of vit K supplementation (0, 2, 8, 16 and 32 mg/kg) with four experimental units. An experimental diet was fed during the growing phase, and the commercial diet was fed during the production phase and were analysed for biochemistry and bone variables at 18 and 32 weeks. In pullets, a significant interaction of levels of vit K and Ca was observed for total serum calcium (mg/dl), Seedor index, Ca in the bones (%) and medullary bone (%). Pullets at 18 weeks of age, receiving diets with 1.4% Ca, displayed a quadratic effect of vit K with better results for these variables with 17.86, 14.59, 14.48 and 16.80 mg/kg of vit K, respectively. For level 0.8% Ca no effect of vit K was observed. The treatments during the growing phase had no effect on egg production, performance and biochemistry serum until 32 weeks. Medullary bone (%), there was a significant interaction for 1.4% Ca and a quadratic effect for vit K, with greater medullary bone areas observed with 6.09 mg/kg vit K in the diet. Supplementation with vit K in a diet with 1.4% Ca during the growing phase allowed for an increase in the area of medullary bone at 18 weeks, which was maintained until 32 weeks.

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Vitamin K and Bone: Past, Present, and Future

Cited by 14 publications

References 36 publications

Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

Bone and glucose metabolism: A two-way street

Influence of graded levels of calcium and vitamin K in the diets of laying hens during the growing phase and their effects on the laying phase

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