Vitamin K and cancer

Dahlberg, Sofia; Ede, Jacob; Schött, Ulf

doi:10.1080/00365513.2017.1379090

Cited by 42 publications

(31 citation statements)

References 131 publications

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“…Additionally, it is known that PIVKA-II is produced by the liver not only in presence of neoplastic cells, but also in absence of vitamin K ( 12 ). Various in vitro and in vivo studies have demonstrated anti-carcinogenic effects played by vitamin K both directly (due to its ability to suppress cancer growth and cause apoptosis in neoplastic cells) and indirectly through post-translational activation of proteins including PIVKA-II, which have thus been proposed as tumour markers for diverse types of malignancies ( 10 ). According to these findings, the hypothetical mechanism we speculate for PIVKA-II high concentrations in PC is that they could reflect a possible association between vitamin K status and PC.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a rising attention has been focusing on the relationship between vitamin K and malignancy. Regarding PC, multiple studies have confirmed that apoptosis has a key role in vitamin K-induced pancreatic cell death and the contribution of vitamin K against PC cell oncogenesis has been recently evaluated, with all studies having the common topic of apoptosis ( 10 , 11 ). In the light of these recent articles, we decided to investigate the role of prothrombin induced by vitamin K absence II (PIVKA-II).…”

Section: Introductionmentioning

confidence: 99%

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Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study

Tartaglione

Pecorella

Zarrillo

et al. 2019

Biochem. med. (Online)

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Introduction: Protein induced by vitamin K absence II (PIVKA-II) is an abnormal prothrombin increased in gastrointestinal malignancy. We aimed to evaluate PIVKA-II in comparison to established pancreatic cancer (PC) biomarkers (CA 19-9, carcinoembryonic antigen (CEA) and CA 242) measured in PC patients and in patients with benign pancreatic diseases. Materials and methods: We studied 26 PC patients (Group 1) and 20 patients with benign pancreatic diseases (Group 2). PIVKA-II and CEA were measured by chemiluminescent enzyme immunoassay method (CLEIA) on LUMIPULSE G1200 (Fujirebio-Europe, Gent, Belgium), CA 19-9 and CA 242 were measured by ELSA (CisBio Bioassays, Codolet, France) and EIA (Fujirebio Diagnostics AB, Göteborg, Sweden), respectively. Receiver operating characteristic (ROC) analysis was performed to assess biomarkers’ diagnostic characteristics in both groups. Results: Median and interquartile range (IQR) in Group 1 and Group 2 were: 1749.0 (320.2 – 3921.0) vs. 31.0 (23.0 – 43.0) mAU/mL (P < 0.001) for PIVKA-II, 260.0 (158.7 – 272.0) vs. 45.2 (9.0 – 58.0) U/mL (P = 0.034) for CA 19-9, 104.0 (30.2 – 150.0) vs. 7.2 (4.8 – 26.0) U/mL (P < 0.050) for CA 242, 9.4 (5.3 – 37.5) vs. 4.5 (1.8 – 7.0) ng/mL (P = 0.021) for CEA. Areas under the ROC curve of PIVKA-II, CA 19-9, CA 242, CEA were 0.86 (95% CI: 0.71 – 1.00), 0.58 (95% CI: 0.38 – 0.78), 0.73 (95% CI: 0.54 – 0.92), 0.64 (95% CI: 0.44 – 0.85), respectively. Conclusions: PIVKA-II is significantly higher in PC than in benign pancreatic diseases. PIVKA-II shows a rather good diagnostic performance compared to CA 19-9, CEA and CA242, thus its determination could help PC management.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study

Tartaglione

Pecorella

Zarrillo

et al. 2019

Biochem. med. (Online)

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“…Seventeen patients had different types of cancer. The prolonged suboptimal function of Gla proteins can increase the risk of cancer, as suggested by studies where vitamin K intake was inversely correlated to cancer incidence [ 28 , 29 ], as well as by the documented anti-carcinogenic effects of vitamin K [ 30 ]. The expression of MGP has been investigated in several cancer types, but no clear role has been established [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients

et al. 2018

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Background: Matrix Gla protein (MGP) is an extrahepatic protein that is dependent on glutamate carboxylation, a vitamin K-dependent process. Its dysfunctional form, desphospho-uncarboxylated-MGP, has been associated with increased arterial calcification and stiffness. The aim of this study was to measure the degree of postoperative carboxylation of MGP and two other Gla proteins in patients scheduled for abdominal or orthopaedic surgery. Methods: Forty patients undergoing abdominal or orthopaedic surgery were included. Blood samples were collected preoperatively and four days after the surgery. Desphospho-carboxylated MGP (dp-cMGP), desphospho-uncarboxylated MGP (dp-ucMGP), carboxylated osteocalcin (OC) (cOC), uncarboxylated OC (ucOC), and uncarboxylated prothrombin (PIVKA-II) were analysed. Results: Preoperatively, 29 patients had dp-ucMGP levels above the reference values. Patients with pre-existing cardiovascular comorbidities had higher dp-ucMGP preoperatively compared with patients with no record of cardiovascular disease. Postoperatively, this number increased to 36 patients, and median dp-ucMGP levels increased (p < 0.0001) and correlated to a PIVKA-II increase (r = 0.44). On the other hand, dp-cMGP levels did not significantly alter. Decreased levels of ucOC and cOC were seen after surgery (p = 0.017 and p = 0.0033, respectively). Comorbidities, possible nutritional defects, and complications affecting Gla protein activity and function were identified. Conclusions. Dp-ucMGP was high preoperatively, and had further increased postoperatively. This pattern was linked to several comorbidities, possible nutritional defects, and postoperative complications, which motivates further research about potential interactions between perioperative corrective treatments with vitamin K supplements, cardiovascular biomarkers, and incidents of stroke and myocardial infarction events.

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“…Vitamin K2 administration in vivo inhibits the cellular proliferation of several types of cancers [ 72 , 73 ]. Many studies investigated the role of vitamin K intake and supplementation in the prevention of cancer development, progression, and recurrence [ 74 ].…”

Section: Vitamin K a Family Of Vitamers: Types Status And Vitammentioning

confidence: 99%

Vitamin K and Kidney Transplantation

Fusaro

Cosmai

Evenepoel³

et al. 2020

Nutrients

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The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches.

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Vitamin K and cancer

Cited by 42 publications

References 131 publications

Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study

Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients

Vitamin K and Kidney Transplantation

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