Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

Fear, Nicola T.; Roman, Eve; Ansell, Pat; Simpson, Jill; Day, Nick; Eden, O. B.

doi:10.1038/sj.bjc.6601278

Cited by 46 publications

(23 citation statements)

References 22 publications

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“…A risk of solid tumours can now almost definitely be ruled out, but a small risk of leukaemia cannot be excluded. [17,35]. When cases of late VKDB started to reappear, Denmark, Canada, Australia and New Zealand responded by reintroducing universal IM prophylaxis, offering oral prophylaxis with repeated doses to those parents refusing the IM injection at birth.…”

Section: Vitamin K Prophylaxis In the Newbornmentioning

confidence: 97%

Vitamin K, an update for the paediatrician

et al. 2008

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Section: Vitamin K Prophylaxis In the Newbornmentioning

confidence: 97%

Vitamin K, an update for the paediatrician

et al. 2008

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“…Previous research has shown that most homeopaths do not recommend MMR vaccination. 26,27 However, there has been less publicity over concerns about a possible link between vitamin K and childhood cancer 28 than about MMR. We show in this study that views of immunity associated with homeopathic conceptions of health disease are widespread, while consultation with a homeopath was itself strongly associated with non-compliance.…”

Section: Limitations Of This Studymentioning

confidence: 99%

Is the cultural context of MMR rejection a key to an effective public health discourse?

et al. 2006

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Summary Objectives: (1) To explore the social and cultural influences, and health beliefs associated with low uptake of MMR (measles, mumps and rubella vaccine). (2) To describe and explore the prevalence of health beliefs associated with noncompliance with MMR, with a view to improving the personal relevance and impact of information for parents, in the context of persisting low uptake following public controversy. Methods: We undertook a survey of mothers' experiences of and attitudes to the MMR, developed through ethnographic study, which was linked to maternal and child information on the Child Health Database in Brighton, England. Results: Mothers interpret MMR risk through concepts of child health embedded in family health history, with a majority both of compliers and non-compliers holding that each child's immune system is unique. Cultural 'risk factors' for non-compliance relate strongly to the use of complementary healthcare, such as homeopathy, with evidence that rejection of vitamin K is associated with MMR non-compliance. Forty per cent, both of compliers and non-compliers, did not consider the possible benefits to other children of MMR. Conclusions: These findings have paradoxical and challenging consequences for the promotion of immunization in the policy context of increasing emphasis on healthy choices. They demonstrate the need for immunization information that acknowledges and addresses lay concepts of immunity.

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“…The reported association between i.m. injection of vitamin K at birth and childhood cancer (14) has now largely been refuted (15); however, the suprapharmacological vitamin K levels that follow excessive prophylaxis may conceivably have adverse consequences, as yet unrecognized.…”

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confidence: 99%

Urinary Excretion of Vitamin K Metabolites in Term and Preterm Infants: Relationship to Vitamin K Status and Prophylaxis

et al. 2010

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ABSTRACT:Little is known about the metabolic turnover and excretion of vitamin K in healthy newborn infants and the metabolic consequences of prophylactic regimens designed to protect against vitamin K deficiency bleeding (VKDB). We measured the excretion of two urinary metabolites (Յ24 h) of vitamin K (5C-and 7C-aglycones) in term infants before (n ϭ 11) and after (n ϭ 5) a 1000 g i.m. dose of vitamin K 1 (K 1 ) and in preterm infants after 200 g i.m. (n ϭ 4), 500 g i.m. (n ϭ 4), or 200 g i.v. (n ϭ 5). In preterm infants, we also measured serum K 1 , vitamin K 1 2,3-epoxide, and PIVKA-II at 5 d postpartum. Before prophylaxis, the rate of 5C-and 7C-aglycone excretion was 25 times lower than adults, reflecting low vitamin K stores at birth. After prophylaxis, the excretion rate correlated to K 1 dose (r ϭ 0.6) but was two orders of magnitude lower than that in adults, probably reflecting the immaturity of neonatal catabolism. All term and 10 of 13 preterm infants mainly excreted 5C-aglycone. We present evidence that increased excretion of the 7C-aglycone was associated with metabolic overload because of the exposure to high-tissue K 1 concentrations. Measurement of the 5C-and 7C-aglycones may facilitate longitudinal studies of vitamin K status in neonates and aid the development of improved prophylactic regimens. (Pediatr Res 68: 508-512, 2010)

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Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

Cited by 46 publications

References 22 publications

Vitamin K, an update for the paediatrician

Vitamin K, an update for the paediatrician

Is the cultural context of MMR rejection a key to an effective public health discourse?

Urinary Excretion of Vitamin K Metabolites in Term and Preterm Infants: Relationship to Vitamin K Status and Prophylaxis

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