Vitamin K and metabolic bone disease.

Vermeer, Cees; Knapen, Marjo H. J.; Schurgers, Leon J.

doi:10.1136/jcp.51.6.424

Cited by 41 publications

(21 citation statements)

References 29 publications

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“…Les ménaquinones (MK7, 8 et 9) sont surtout retrouvées dans les foies d'animaux, les fromages, le lait caillé et les aliments fermentés comme la choucroute [8].…”

Section: Sources Et Besoinsunclassified

“…Ainsi un apport de 1 pg/kg par jour est suffisant pour maintenir une activité coagulante normale. Mais la carboxylation des protéines osseuses pourrait nécessiter un apport plus important en vitamine K que celui qui est nécessaire à la carboxylation des protéines ayant une activité dans la coagulation [8].…”

Section: Vitamine K Et Osunclassified

“…Par ailleurs, il a été suggéré récemment que les protéines gammacarboxylées synthétisées par l'os nécessiteraient des besoins supérieurs en vitamine K pour obtenir une carboxylation complète par rapport aux protéines gammacarboxylées de la coagulation synthétisée par le foie [8].…”

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Actualité sur la vitamine K

Guillaumont¹

2000

OCL

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Summary:The difficulty of quantifying vitamin K levels and determining the number of active molecules long impeded in investigations into the metabolism and physiological function of vitamin K. In the last ten years, since gamma carboxylation was first demonstrated, studies have essentially focused on: -vitamin K sources and requirements: the composition of foods and requirements with respect to molecules with vitamin K activity are beginning to be known; -vitamin K and bone: the role of osteocalcin in bone mineralization and its association with vitamin K have been studied, particularly in elderly subjects; -hemorrhagic disease of the newborn: after a number of controversies, it is now generally accepted that prophylactic treatment of all newborns should be systematic, and repeated for breast-fed infants. Vitamin K should be administerted orally except in cases of malabsorption. However, a number of essential questions remain unanswered, such as the precise role played by certain carboxyproteins (bone carboxyprotein or Gas6) and, in particular, the choice of markers for the accurate evaluation of vitamin K status in humans.Keywords: vitamin K, bone, newborn. ARTICLE Sources et besoinsIl existe assez peu de données précises sur la composition des aliments en vitamines en raison de la complexité du dosage. Ce dosage est basé sur la réduction du noyau quinone suivi d'une détection par fluorescence ou par électrochimie [6].Si la phylloquinone est présente dans de nombreux aliments, les concentrations sont faibles. Seuls les légumes verts comme les épinards, les choux et les brocolis contiennent des concentrations importantes de phylloquinone (tableau) [7].Les ménaquinones (MK7, 8 et 9) sont surtout retrouvées dans les foies d'animaux, les fromages, le lait caillé et les aliments fermentés comme la choucroute [8].La biodisponibilité de la vitamine K peut varier considérablement en fonction de la teneur en lipides et de la lipophilie des formes de la vitamine K [9].Les besoins en vitamine K sont donc difficiles à apprécier mais les auteurs sont néanmoins d'accord pour dire qu'ils sont extrêmement faibles car le mécanisme de recyclage est très efficace. Ils sont Article disponible sur le site http://www.ocl-journal.org ou http://dx

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“…Les ménaquinones (MK7, 8 et 9) sont surtout retrouvées dans les foies d'animaux, les fromages, le lait caillé et les aliments fermentés comme la choucroute [8].…”

Section: Sources Et Besoinsunclassified

Section: Vitamine K Et Osunclassified

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Actualité sur la vitamine K

Guillaumont¹

2000

OCL

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“…Values for MK-4 to MK-10 are available. MK-4 is found in all reported products except buckwheat, hikiwari natto, and black bean natto [6,27,[29][30][31][32][33][34][35]. In non-fermented dairy products and in eggs, hardly any longer-chain menaquinones have been reported [6,27,29,32].…”

Section: Dietary Sources Of Menaquinonesmentioning

confidence: 99%

Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet

Walther¹,

Chollet²

2017

Vitamin K2 - Vital for Health and Wellbeing

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Vitamin K2 is a collection of isoprenologues that mostly originate from bacterial synthesis, also called menaquinones (MKs). Multiple bacterial species used as starter cultures for food fermentation are known to synthesize MK. Therefore, fermented food is the best source of vitamin K2. In the Western diet, dairy products are one of the best known and most commonly consumed group of fermented products.Although intensive research on metabolism and the biological effect of vitamin K2 continues today, data about vitamin K2 production and content in foods remain scarce. Dietary recommendations are still based on the classic role of vitamin K as an enzyme cofactor for coagulation proteins and do not consider differences in bioavailability and bioactivity between the various MKs and the possibly higher requirements for health effects apart from coagulation, such as bone or cardiovascular health. Here, we provide a global view of foods rich in vitamin K2 and their interactions together with other nutrients in selected health effects such as bone and cardiovascular health.

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“…OC acts in a similar manner by adhering to hydroxyapatite and influencing bone remodelling but its main function has been suggested as a regulator of bone maturation and turnover, rather than a marker of bone formation 8,83 . Neither can bind to hydroxyapatite unless carboxylated, since undercarboxylated proteins have a poor affinity for calcium 102 .…”

Section: Mechanisms Of Effect Of Vitamin Kmentioning

confidence: 99%

Cardiovascular Calcification and Bone: A Comparison of the Effects of Dietary and Serum Vitamin K and its Dependent Proteins

Nicoll¹,

Howard²,

Henein³

2015

ICFJ

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This review compares the effect of vitamin K on cardiovascular (CV) calcification and bone health and shows that, in principal, the γ-carboxylation of the vitamin K-dependent proteins matrix Gla protein (MGP) and its bone equivalent osteocalcin (OC), generally ensures that hydroxyapatite is kept out of the CV system and is deposited in bone. This is an important finding, since there is currently no reliable treatment for CV calcification.Vitamin K2 (menaquinone) may be more effective in the arteries, while vitamin K1 (phylloquinone) is more active in bone. Nevertheless, there remains considerable uncertainty over the precise scope of the functions of MGP and OC, and their carboxylated and under-carboxylated forms, as well as the newly discovered vitamin K-dependent proteins. Although a diet high in vegetables could deliver adequate phylloquinone, supplementation of menaquinone may be necessary for those at risk of CV calcification. Several animal studies and one human study have demonstrated that arterial calcification could be reduced with vitamin K supplementation and there are further trials in progress. Patients on warfarin are particularly prone to CV calcification but there has been concern that supplementation would either counter warfarin treatment or destabilise INR. In fact, studies suggest that low dose phylloquinone did not increase coagulation and may improve the stability of anticoagulant therapy. Furthermore, use of oral anticoagulants which do not affect vitamin K metabolism, such as ximelagatran, could be used when there is a need for vitamin K supplementation for artery or bone health.

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Vitamin K and metabolic bone disease.

Cited by 41 publications

References 29 publications

Actualité sur la vitamine K

Actualité sur la vitamine K

Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet

Cardiovascular Calcification and Bone: A Comparison of the Effects of Dietary and Serum Vitamin K and its Dependent Proteins

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