2006
DOI: 10.1001/archinte.166.12.1256
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Vitamin K and the Prevention of Fractures

Abstract: This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.

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Cited by 325 publications
(97 citation statements)
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“…In a population without liver disease, suboptimal vitamin K status has been associated with an increased risk of fractures, and supplementation has been associated with improvements in BMD. 15 …”
Section: Pathophysiology Of Osteoporosismentioning
confidence: 99%
“…In a population without liver disease, suboptimal vitamin K status has been associated with an increased risk of fractures, and supplementation has been associated with improvements in BMD. 15 …”
Section: Pathophysiology Of Osteoporosismentioning
confidence: 99%
“…Furthermore, the fracture-preventing effect of vitamin K was observed in several clinical studies in Japan, which was confirmed by meta-analysis [15]. Based on these results, vitamin K2 is used for treatment of osteoporosis in several Asian countries.…”
Section: Vitamin K2 -Vital For Health and Wellbeingmentioning
confidence: 57%
“…Furthermore, a 2006 review and 2009 study report describe 8 clinical trials that assessed the effects of vitamin K2 supplementation on fracture incidence in osteoporotic Japanese patients (7,8) . Seven trials conducted in the 2006 study showed significant reduction in hip, vertebral, and nonvertebral fractures from adults supplemented with vitamin K2 (MK-4 of 15-45 mg/day) over 12-24 months (7) .…”
Section: What Do the Research Clinical Trials Say About Vitamin K Effmentioning
confidence: 99%
“…Seven trials conducted in the 2006 study showed significant reduction in hip, vertebral, and nonvertebral fractures from adults supplemented with vitamin K2 (MK-4 of 15-45 mg/day) over 12-24 months (7) . However, the 8th 'outlier trial' in 2009 demonstrated that vitamin K2 supplementation did not significantly reduce the incidence of fracturing.…”
Section: What Do the Research Clinical Trials Say About Vitamin K Effmentioning
confidence: 99%