Vitamin K deficiency bleeding presenting as impending brain herniation

Gopakumar, Harishankar; Sivji, R; Rajiv, PK

doi:10.4103/1817-1745.66681

Cited by 11 publications

(8 citation statements)

References 5 publications

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“…Therefore, it should be seriously considered. 18 Nyquist reported in good outcomes with surgical therapy after spontaneous ICH in children. 19 Vitamin K deficient hemorrhagic diathesis is well-known as a cause of infantile intracranial hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…In sufficient quantities, fresh frozen plasma can correct, or nearly correct, the PT, as well as the bleeding tendency. 1,6,9,14,17,18 At present, aggressive surgical management to evacuate clots in patients with acute ICH is not indicated, except in cases of cerebellar ICH. The International Surgical Trial in Intracerebral Hemorrhage (ISTICH) suggested there was no clinical benefit from conventional surgical clot evacuation when compared with conservative medical management in acute ICH.…”

Section: Discussionmentioning

confidence: 99%

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Good outcomes in operative management of acquired prothrombin complex deficiency: a serial case report

Dewi

Nurfitri

Evodia

et al. 2011

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Background Acquired prothrombin complex deficiency (APCD) is a serious bleeding disorder in infants caused by idiopathic vitamin K deficiency. This disorder has a high mortality rate and sequelae are often seen in those that survive. The principal treatments are giving vitamin K and evacuating hemorrhages. Objective To report the outcome of surgical and non-surgical management in several cases of APCD. Method Eighteen infants diagnosed with APCD had similar histories: all were less than 4 months of age as well as exclusively breastfed, and none received vitamin K injections after birth. The diagnosis of APCD was made based on prolonged prothrombin times and proven intracranial hemorrhage on brain CT-scan. All subjects were treated with vitamin K injections for 5 days and offered craniotomy procedures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Good outcomes in operative management of acquired prothrombin complex deficiency: a serial case report

Dewi

Nurfitri

Evodia

et al. 2011

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“…The disease has been subclassified as early VKDB (within the first day of life), classic VKDB (within the first week), or late VKDB (second week to six months of age) 6,12,16,28,29,35,38 . Early VKDB, occurring on the first day of life, is rare and confined to infants born to mothers who have received medications that interfere with vitamin K metabolism.…”

Section: Vitamin K For Treatment Of Haemorrhagic Disease Of the Infantsmentioning

confidence: 99%

Vitamin K Prophylaxis in Infants

Lihanova¹

2018

Preprint

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A high incidence of Vitamin K deficiency bleeding (VKDB) in breastfed infants can cause life-long disability, especially if they occur in the brain. The way in which infants are administered vitamin K varies by country. Research on the optimal regimen of vitamin K prophylaxis administration has some limitations. There are no studies that directly compare the effect of different routes of administration of vitamin K to prevent bleeding. We summarized overview of Vitamin K policy for infants of VKDB in various countries.

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“…In the setting of vitamin K deficiency, an abnormal form of coagulation factor II, also referred to as 'protein induced by vitamin K absence' under-c-carboxylated prothrombin (PIVKA-II), is released into the bloodstream and can be directly measured (Gopakumar et al 2010). PIVKA-II is unique in that it can help identify early or subclinical vitamin K deficiency.…”

Section: Figurementioning

confidence: 99%

Establishing a rat model for the study of vitamin K deficiency

Xiao

Liu

et al. 2016

Int J Experimental Path

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The main vitamin K-deficient model, minidose warfarin, is different from the pathological mechanism of vitamin K deficiency, which is a shortage of vitamin K. The objective of this study was to establish a new method of vitamin K-deficient model combining a vitamin K-deficient diet with the intragastrical administration of gentamicin in rats. The clotting was assayed by an automated coagulation analyser. The plasma PIVKA-II was assayed by ELISA. The vitamin K status was detected by an HPLC-fluorescence system. In the diet- and gentamicin-induced vitamin K-deficient 14-day group, the rats had undetected vitamin K1 and vitamin K2 in the liver and a prolonged APTT. In the 21-day group, there was also a prolonged PT and a decrease of the FIX activities. In the 28-day group, the undetected vitamin K1 and vitamin K2, the prolonged PT and APTT, and the decrease of the FII, FVII, FIX, and FX activities prompted the suggestion that there were serious deficiencies of vitamin K and vitamin K-dependent coagulation in rats. It is suggested that the diet- and gentamicin-induced vitamin K-deficient 14-day or 21-day model can be used for studies related to the status of vitamin K. The vitamin K-deficient 28-day model can be applied to research involving both the status of vitamin K and of vitamin K-dependent coagulation. In conclusion, the combination of a vitamin K-deficient diet with the administration of gentamicin results in a useful model of vitamin K-deficieny.

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Vitamin K deficiency bleeding presenting as impending brain herniation

Cited by 11 publications

References 5 publications

Good outcomes in operative management of acquired prothrombin complex deficiency: a serial case report

Good outcomes in operative management of acquired prothrombin complex deficiency: a serial case report

Vitamin K Prophylaxis in Infants

Establishing a rat model for the study of vitamin K deficiency

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